{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:25:16Z","timestamp":1793996716970,"version":"4.8.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Beijing Life Science Academy","award":["2024600CC0260"],"award-info":[{"award-number":["2024600CC0260"]}]},{"name":"Beijing Life Science Academy","award":["2024601QPID08"],"award-info":[{"award-number":["2024601QPID08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2026,1,14]]},"DOI":"10.1021\/acs.jafc.5c15405","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T16:50:14Z","timestamp":1766422214000},"page":"983-997","source":"Crossref","is-referenced-by-count":9,"title":["Natural Dietary Flavonoid Apigenin Mitigates Ulcerative Colitis via Modulating the AMPK\/NF-\u03baB\/NLRP3 Signaling Axis"],"prefix":"10.1021","volume":"74","author":[{"given":"Mengsha","family":"Zhou","sequence":"first","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Zhengzhou Tobacco Research Institute of CNTC","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuang","family":"Mao","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-En","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica","place":["Tianjin, China"]},{"name":"Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Zhengzhou Tobacco Research Institute of CNTC","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Zhengzhou Tobacco Research Institute of CNTC","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Mao","sequence":"additional","affiliation":[{"name":"China Tobacco Fujian Industrial Co., Ltd","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-6315","authenticated-orcid":true,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Zhengzhou Tobacco Research Institute of CNTC","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-6376","authenticated-orcid":true,"given":"Guihong","family":"Qi","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.08.003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.23814"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0335-4"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0167-x"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.03.003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116302"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S481769"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0632-z"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.10.041"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1666"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.87"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.01.002"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7973098"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70223"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1062961"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156519"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.180"},{"key":"ref20\/cit20","first-page":"1","volume":"41","author":"da Costa Gon\u00e7alves F.","year":"2013","journal-title":"Acta Scientiae Veterinari"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24406"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2269-7_19"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0318-0"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.7150\/thno.53105"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00891-0"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.783254"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1497984"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156564"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040967"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101661"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0748-0"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.02.047"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.10.009"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01994-9"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00547-x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20793"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12061353"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.681477"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087286"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121530"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad312"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c15405","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c15405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:10:23Z","timestamp":1768565423000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5c15405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,14]]}},"alternative-id":["10.1021\/acs.jafc.5c15405"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c15405","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}