{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:40:01Z","timestamp":1794282001323,"version":"4.9.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY21C200002"],"award-info":[{"award-number":["LY21C200002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["GQD24SH38"],"award-info":[{"award-number":["GQD24SH38"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent studies indicate that 2\u2032-fucosyllactose (2\u2032-FL), a human milk oligosaccharide, alleviates inflammatory bowel disease (IBD) by modulating the gut microbiota, yet the underlying mechanisms and key functional bacteria involved remain unclear. This study employed fecal microbiota transplantation and an antibiotic-treated mouse model to investigate the role of 2\u2032-FL-mediated gut microbiota in lipopolysaccharide-induced colitis, with a focus on Akkermansia muciniphila (A. muciniphila). Results demonstrated that 2\u2032-FL intervention significantly enriched A. muciniphila in the gut and promoted the production of short-chain fatty acids (SCFAs). Fecal microbiota transplantation experiments confirmed that 2\u2032-FL-modulated microbiota reshaped the gut ecosystem in recipient mice. Notably, monocolonization with A. muciniphila alone alleviated colitis, while coadministration of 2\u2032-FL synergistically enhanced anti-inflammatory effects and SCFAs production. These findings reveal that 2\u2032-FL operates via a \u201cprebiotic-key bacterium-metabolite\u201d axis, wherein A. muciniphila acts as a mediator to metabolize 2\u2032-FL into SCFAs, orchestrating anti-inflammatory and barrier-protective responses.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c15443","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T09:34:16Z","timestamp":1780652056000},"page":"17898-17912","source":"Crossref","is-referenced-by-count":1,"title":["The Prebiotic 2\u2032-Fucosyllactose\nAmeliorates\nColitis via an\n                    <i>Akkermansia muciniphila<\/i>\n                    -Mediated Prebiotic-Microbiota-Metabolite Axis"],"prefix":"10.1021","volume":"74","author":[{"given":"Ruizhi","family":"Xia","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Ge","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-4988","authenticated-orcid":true,"given":"Yuying","family":"Shuai","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"8","key":"2026073021200822200_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080708","article-title":"Metabolic Host\u2013Microbiota Interactions in Autophagy\nand the Pathogenesis of Inflammatory Bowel Disease (IBD)","volume":"14","author":"Dowdell","year":"2021","journal-title":"Pharmaceuticals"},{"key":"2026073021200822200_cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.733992","article-title":"The Gut Microbiota\nin Inflammatory Bowel Disease","volume":"12","author":"Qiu","year":"2022","journal-title":"Front. Cell.\nInfect. Microbiol."},{"issue":"10","key":"2026073021200822200_cit3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut Microbiota and\nIBD: Causation or Correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat. Rev. Gastroenterol.\nHepatol."},{"issue":"7","key":"2026073021200822200_cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-022-03069-4","article-title":"Changes of Intestinal\nMicrobiota and Microbiota-Based Treatments in IBD","volume":"204","author":"Li","year":"2022","journal-title":"Arch. Microbiol."},{"issue":"2","key":"2026073021200822200_cit5","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1093\/nutrit\/nuae002","article-title":"The Effect\nof Oral Synbiotics on the Gut Microbiota and Inflammatory Biomarkers\nin Healthy Adults: A Systematic Review and Meta-Analysis","volume":"83","author":"Cosier","year":"2025","journal-title":"Nutr. Rev."},{"issue":"12","key":"2026073021200822200_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/biom11121903","article-title":"Prebiotics, Probiotics, Synbiotics,\nParaprobiotics and Postbiotic Compounds in IBD","volume":"11","author":"Martyniak","year":"2021","journal-title":"Biomolecules"},{"issue":"14","key":"2026073021200822200_cit7","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3748\/wjg.v29.i14.2078","article-title":"Role of Prebiotics, Probiotics, and Synbiotics in Management\nof Inflammatory Bowel Disease: Current Perspectives","volume":"29","author":"Roy","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"2026073021200822200_cit8","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2186115","article-title":"Functional\nEffects of Human Milk Oligosaccharides (HMOs)","volume":"15","author":"Dinleyici","year":"2023","journal-title":"Gut Microbes"},{"issue":"20","key":"2026073021200822200_cit9","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204466","article-title":"Roles of Short-Chain\nFatty Acids in Inflammatory Bowel\nDisease","volume":"15","author":"Shin","year":"2023","journal-title":"Nutrients"},{"issue":"4","key":"2026073021200822200_cit10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.clnu.2024.02.030","article-title":"Maternal\nPrebiotic Supplementation during Pregnancy and Lactation Modifies\nthe Microbiome and Short Chain Fatty Acid Profile of Both Mother and\nInfant","volume":"43","author":"Jones","year":"2024","journal-title":"Clin. Nutr."},{"issue":"9","key":"2026073021200822200_cit11","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1016\/j.tjnut.2024.07.031","article-title":"Infant Microbiota Communities and Human Milk Oligosaccharide\nSupplementation Independently and Synergistically Shape Metabolite\nProduction and Immune Responses in Healthy Mice","volume":"154","author":"Tripp","year":"2024","journal-title":"J. Nutr."},{"issue":"11","key":"2026073021200822200_cit12","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11112659","article-title":"2-Fucosyllactose\nMetabolism by Bifidobacteria Promotes Lactobacilli Growth in Co-Culture","volume":"11","author":"Nogacka","year":"2023","journal-title":"Microorganisms"},{"key":"2026073021200822200_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104785","article-title":"2\u2032-Fucosyllactose\nPromotes the Enrichment of Akkermansia Muciniphila and the Production of Short-Chain Fatty Acids in Vitro and in Vivo","volume":"61","author":"Ge","year":"2024","journal-title":"Food Biosci."},{"key":"2026073021200822200_cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.102317","article-title":"The Protective\nEffect of 2\u2032-Fucosyllactose on LPS-Induced Colitis Suckling Mice by Ameliorating Intestinal Inflammation and Modulating\nGut Microbiota","volume":"51","author":"Lv","year":"2023","journal-title":"Food Biosci."},{"issue":"24","key":"2026073021200822200_cit15","doi-asserted-by":"publisher","first-page":"9349","DOI":"10.1021\/acs.jafc.2c08814","article-title":"Galactooligosaccharide\nor 2\u2032-Fucosyllactose Modulates Gut\nMicrobiota and Inhibits LPS\/TLR4\/NF-\u03baB Signaling Pathway to\nPrevent DSS-Induced Colitis Aggravated\nby a High-Fructose Diet in Mice","volume":"71","author":"Chen","year":"2023","journal-title":"J. Agric. Food\nChem."},{"issue":"1","key":"2026073021200822200_cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10430-7","article-title":"Heterochronic\nFaecal Transplantation\nBoosts Gut Germinal Centres in Aged Mice","volume":"10","author":"Stebegg","year":"2019","journal-title":"Nat.\nCommun."},{"key":"2026073021200822200_cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02498","article-title":"Protective\nRole of Fecal Microbiota Transplantation on Colitis and Colitis-Associated\nColon Cancer in Mice Is Associated With Treg Cells","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Microbiol."},{"key":"2026073021200822200_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124199","article-title":"The Preventive Effect\nof Glycyrrhiza Polysaccharide on Lipopolysaccharide-Induced\nAcute Colitis in Mice by Modulating Gut Microbial Communities","volume":"239","author":"Wei","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"2026073021200822200_cit19","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.1021\/acs.jafc.3c08305","article-title":"2\u2032-Fucosyllactose\nPromotes\nColonization of Akkermansia Muciniphila and Prevents Colitis In Vitro and in Mice","volume":"72","author":"Liu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"2026073021200822200_cit20","doi-asserted-by":"publisher","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic\nDiagramming Platform (GDP): A Comprehensive Database of High-Quality\nBiomedical Graphics","volume":"53","author":"Jiang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"2026073021200822200_cit21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.934695","article-title":"Akkermansia Muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory\nBowel Disease, Obesity, and Diabetes","volume":"13","author":"Rodrigues","year":"2022","journal-title":"Front.\nImmunol."},{"key":"2026073021200822200_cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1089600","article-title":"The Role of Akkermansia Muciniphila in Inflammatory Bowel Disease: Current\nKnowledge and Perspectives","volume":"13","author":"Zheng","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"2026073021200822200_cit23","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v15.i2.92592","article-title":"Gut Virome:\nNew Key Players in the\nPathogenesis of Inflammatory Bowel Disease","volume":"15","author":"Hetta","year":"2025","journal-title":"World J. Methodol."},{"issue":"3","key":"2026073021200822200_cit24","doi-asserted-by":"publisher","first-page":"297","DOI":"10.59249\/JOMF5336","article-title":"Bowel Inflammation\nand Nutrient Supplementation: Effects of a Fixed Combination of Probiotics,\nVitamins, and Herbal Extracts in an In Vitro Model of Intestinal Epithelial\nBarrier Dysfunction","volume":"97","author":"Tinazzi","year":"2024","journal-title":"Yale J. Biol. Med."},{"issue":"48","key":"2026073021200822200_cit25","doi-asserted-by":"publisher","first-page":"5212","DOI":"10.3748\/wjg.v30.i48.5212","article-title":"Role of\nCandida Species in Pathogenesis, Immune Regulation, and Prognostic\nTools for Managing Ulcerative Colitis and Crohn\u2019s Disease","volume":"30","author":"Patnaik","year":"2024","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"2026073021200822200_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70418","article-title":"2\u2032-Fucosyllactose\nModulates the Intestinal Immune Response to Gut Microbiota and Buffers\nExperimental Colitis in Mice: An Integrating Investigation of Colonic\nProteomics and Gut Microbiota Analysis","volume":"13","author":"Dong","year":"2025","journal-title":"Food\nSci. Nutr."},{"issue":"9","key":"2026073021200822200_cit27","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.1021\/acs.jafc.3c08305","article-title":"2\u2032-Fucosyllactose\nPromotes\nColonization of Akkermansia muciniphila and Prevents Colitis In vitro and in Mice","volume":"72","author":"Liu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"2026073021200822200_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.112072","article-title":"Differential Responses\non Gut Microbiota\nand Microbial Metabolome of 2\u2032-Fucosyllactose and Galactooligosaccharide\nagainst DSS-Induced Colitis","volume":"162","author":"Liu","year":"2022","journal-title":"Food Res. Int."},{"issue":"1","key":"2026073021200822200_cit29","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1986666","article-title":"Bifidobacterium Catabolism of Human\nMilk Oligosaccharides Overrides Endogenous Competitive Exclusion Driving\nColonization and Protection","volume":"13","author":"Heiss","year":"2021","journal-title":"Gut Microbes"},{"issue":"11","key":"2026073021200822200_cit30","doi-asserted-by":"publisher","first-page":"8865","DOI":"10.3168\/jds.2024-25019","article-title":"Surface Proteins of Bifidobacterium BifidumDNG6 Growing\nin 2\u2032-Fucosyllactose Alleviating Lipopolysaccharide-Induced\nIntestinal Barrier Injury in Vitro","volume":"107","author":"Zhao","year":"2024","journal-title":"J. Dairy\nSci."},{"issue":"9","key":"2026073021200822200_cit31","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1093\/glycob\/cwp082","article-title":"Two Distinct -L-Fucosidases\nfrom Bifidobacterium Bifidum Are Essential\nfor the Utilization of Fucosylated Milk Oligosaccharides and Glycoconjugates","volume":"19","author":"Ashida","year":"2009","journal-title":"Glycobiology"},{"issue":"1","key":"2026073021200822200_cit32","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-016-0867-4","article-title":"Fucosyllactose\nand L-Fucose Utilization\nof InfantBifidobacterium Longum and Bifidobacterium Kashiwanohense","volume":"16","author":"Bunesova","year":"2016","journal-title":"BMC Microbiol."},{"issue":"22","key":"2026073021200822200_cit33","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-Talk between Akkermansia Muciniphila and Intestinal Epithelium\nControls Diet-Induced Obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad.\nSci. U.S.A."},{"issue":"4","key":"2026073021200822200_cit34","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040764","article-title":"Pasteurized Akkermansia Muciniphila Ameliorate the LPS-Induced\nIntestinal Barrier Dysfunction via Modulating AMPK and NF-\u03baB\nthrough TLR2 in Caco-2 Cells","volume":"14","author":"Shi","year":"2022","journal-title":"Nutrients"},{"issue":"42","key":"2026073021200822200_cit35","doi-asserted-by":"publisher","first-page":"13615","DOI":"10.1021\/acs.jafc.2c04410","article-title":"2\u2032-Fucosyllactose Promotes the Production of\nShort-Chain Fatty Acids and Improves Immune Function in Human-Microbiota-Associated\nMice by Regulating Gut Microbiota","volume":"70","author":"Chen","year":"2022","journal-title":"J. Agric.\nFood Chem."},{"issue":"2","key":"2026073021200822200_cit36","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020364","article-title":"Infant Complementary Feeding of Prebiotics\nfor the\nMicrobiome and Immunity","volume":"11","author":"McKeen","year":"2019","journal-title":"Nutrients"},{"key":"2026073021200822200_cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-024-00373-1","article-title":"Designing Function-Specific Minimal\nMicrobiomes from Large Microbial Communities","volume":"10","author":"Raghu","year":"2024","journal-title":"NPJ Syst. Biol. Appl."},{"key":"2026073021200822200_cit38","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00185","article-title":"Intestinal Short Chain\nFatty Acids and Their Link with Diet and Human Health","volume":"7","author":"Ri\u0301os-Covia\u0301n","year":"2016","journal-title":"Front. Microbiol."},{"key":"2026073021200822200_cit39","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02259","article-title":"Administration\nof Akkermansia Muciniphila Ameliorates\nDextran Sulfate Sodium-Induced Ulcerative Colitis in Mice","volume":"10","author":"Bian","year":"2019","journal-title":"Front. Microbiol."},{"issue":"4","key":"2026073021200822200_cit40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043900","article-title":"Akkermansia Muciniphila as a Next-Generation Probiotic in Modulating\nHuman Metabolic Homeostasis and Disease Progression: A Role Mediated\nby Gut\u2013Liver\u2013Brain Axes?","volume":"24","author":"Jian","year":"2023","journal-title":"Int.\nJ. Mol. Sci."},{"issue":"2","key":"2026073021200822200_cit41","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020194","article-title":"Akkermansia Muciniphila Alleviates Persistent Inflammation, Immunosuppression, and Catabolism\nSyndrome in Mice","volume":"13","author":"Xu","year":"2023","journal-title":"Metabolites"},{"issue":"1","key":"2026073021200822200_cit42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A Purified Membrane\nProtein from Akkermansia Muciniphila or the Pasteurized Bacterium Improves Metabolism in Obese and Diabetic\nMice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"issue":"5","key":"2026073021200822200_cit43","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An Increase\nin the Akkermansia Spp. Population Induced by Metformin\nTreatment Improves Glucose\nHomeostasis in Diet-Induced Obese Mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"issue":"5","key":"2026073021200822200_cit44","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051284","article-title":"The Protective\nEffects of 2\u2032-Fucosyllactose Against E. Coli O157","volume":"12","author":"Wang","year":"2020","journal-title":"Nutrients"},{"issue":"18","key":"2026073021200822200_cit45","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183687","article-title":"Short Chain Fatty Acids\n(SCFAs) Are\nthe Potential Immunomodulatory Metabolites in Controlling Staphylococcus\nAureus-Mediated Mastitis","volume":"14","author":"Akhtar","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"2026073021200822200_cit46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021205","article-title":"SCFAs Induce Mouse\nNeutrophil Chemotaxis through the GPR43 Receptor","volume":"6","author":"Vinolo","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"2026073021200822200_cit47","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","article-title":"Short-Chain Fatty Acids Activate GPR41 and GPR43 on\nIntestinal Epithelial Cells to Promote Inflammatory Responses in Mice","volume":"145","author":"Kim","year":"2013","journal-title":"Gastroenterology"},{"issue":"7480","key":"2026073021200822200_cit48","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites Produced\nby Commensal Bacteria Promote Peripheral Regulatory T-Cell Generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"issue":"1","key":"2026073021200822200_cit49","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/mi.2014.44","article-title":"Short-Chain Fatty Acids Induce Both Effector and Regulatory\nT Cells by Suppression of Histone Deacetylases and Regulation of the\nmTOR\u2013S6K Pathway","volume":"8","author":"Park","year":"2015","journal-title":"Mucosal Immunol."},{"issue":"6145","key":"2026073021200822200_cit50","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The Microbial Metabolites,\nShort-Chain Fatty Acids, Regulate Colonic treg Cell Homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"2026073021200822200_cit51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.803101","article-title":"Gut Microbiota as Regulators\nof Th17\/Treg Balance in Patients with\nMyasthenia Gravis","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"issue":"3","key":"2026073021200822200_cit52","doi-asserted-by":"publisher","first-page":"411","DOI":"10.4161\/gmic.29330","article-title":"The Interplay between\nthe Gut Microbiota and the Immune System","volume":"5","author":"Geuking","year":"2014","journal-title":"Gut\nMicrobes"},{"key":"2026073021200822200_cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00445","article-title":"The Role of Probiotics and Prebiotics\nin Inducing Gut Immunity","volume":"4","author":"Vieira","year":"2013","journal-title":"Front. Immunol."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.5c15443","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/23\/17898\/66263269\/acs.jafc.5c15443.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/23\/17898\/66263269\/acs.jafc.5c15443.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:20:12Z","timestamp":1785460812000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/23\/17898\/5232954\/The-Prebiotic-2-Fucosyllactose-Ameliorates-Colitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":53,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2026,6,5]]},"published-print":{"date-parts":[[2026,6,17]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.5c15443","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acs.jafc.5c15443.s001","asserted-by":"subject"}]},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}