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Among them, compounds Ka9 and Ka10 exhibited good antibacterial activity, with MIC values of 6.25 \u03bcg\/mL against both Xoo and Xac, while compound Kc1 exhibited excellent activity against Magnaporthe oryzae (EC50 = 2.56 \u03bcg\/mL) and effectively inhibited succinate dehydrogenase (SDH). Furthermore, molecular docking and dynamics simulations revealed that Kc1 shares a similar binding mode with boscalid in the SDH active site. These findings highlight Kc1 as a promising quinoline-based lead compound for further development and provide a scientific rationale for repurposing natural product scaffolds in sustainable plant protection.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c15481","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T19:01:27Z","timestamp":1786820487000},"page":"26759-26769","source":"Crossref","is-referenced-by-count":0,"title":["Design and Synthesis\nof Potential Quinoline-Based\nSDH Inhibitors Inspired by Quinine Alkaloids with Activity against\nPhytopathogenic Fungi and Bacteria"],"prefix":"10.1021","volume":"74","author":[{"given":"Lu\u2212lu","family":"Qin","sequence":"first","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Ping","family":"Gao","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ya","family":"Guan","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong-Fei","family":"Luo","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-3426","authenticated-orcid":true,"given":"Zhi-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-0913","authenticated-orcid":true,"given":"Ying-Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]},{"name":"Huzhou University , , ,","place":["Huzhou, China, 313000"]},{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"2026090104473681000_cit1","doi-asserted-by":"publisher","first-page":"133798","DOI":"10.1016\/j.chemosphere.2022.133798","article-title":"Potential Applications of Engineered Nanoparticles in Plant Disease\nManagement: A Critical Update","volume":"295","author":"Kumar","year":"2022","journal-title":"Chemosphere"},{"key":"2026090104473681000_cit2","doi-asserted-by":"publisher","first-page":"109224","DOI":"10.1016\/j.plaphy.2024.109224","article-title":"Plant secondary\nmetabolites-mediated plant defense against bacteria and fungi pathogens","volume":"217","author":"Yang","year":"2024","journal-title":"Plant Physiol. 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