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In this study, we designed and synthesized a series of N-acetylhydrazine (amine)-1,2,3-benzothiadiazine-1,1-dioxide derivatives and evaluated their antifungal activity. Compound B2 showed strong activity against Rhizoctonia solani (EC50 = 0.320 \u03bcg\/mL, superior to boscalid 1.25 \u03bcg\/mL) and Fusarium graminearum (EC50 = 0.830 \u03bcg\/mL, comparable to carbendazim 0.880 \u03bcg\/mL), surpassing or comparable to commercial fungicides. Structure\u2013activity relationship and DFT analyses highlighted the importance of substituent selection. Mechanistic studies indicated that B2 disrupted hyphal morphology, increased ROS, and enhanced membrane permeability. Several derivatives also exhibited herbicidal activity against common field weeds, suggesting potential multifunctional agrochemical applications.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c16716","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:22:41Z","timestamp":1784553761000},"page":"22558-22567","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis, and Biological Evaluation of 1,2,3-Benzothiadiazine-1,1-dioxide\nDerivatives as Potential Antifungal and Herbicidal Agents with Preliminary\nMechanism Study"],"prefix":"10.1021","volume":"74","author":[{"given":"Zihua","family":"Ma","sequence":"first","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Lei","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Xie","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpeng","family":"Tang","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1234-1307","authenticated-orcid":true,"given":"Shuguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-5306","authenticated-orcid":true,"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-8016","authenticated-orcid":true,"given":"Peng","family":"Dai","sequence":"additional","affiliation":[{"name":"Anqing Normal University , , ,","place":["Anqing, China, 261433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-025X","authenticated-orcid":true,"given":"Qing","family":"Xia","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026072910064764900_cit1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s43016-020-0075-0","article-title":"Threats to Global Food\nSecurity from Emerging Fungal and Oomycete Crop Pathogens","volume":"1","author":"Fones","year":"2020","journal-title":"Nat. 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