{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:43:52Z","timestamp":1786538632307,"version":"build-2736575974"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302103"],"award-info":[{"award-number":["32302103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The intestinal barrier proves exquisitely sensitive to dietary cues and is intimately linked to the progression of intestinal, metabolic, and systemic disorders. This study explored the effects of eicosapentaenoic acid astaxanthin ester (EA) on high-fat-diet (HFD)-induced intestinal barrier damage based on the modification of gut microecology. The results showed that EA inhibited obesity development, dyslipidemia, and colon inflammation, suppressed colon pathological damage, and restored the intestinal barrier by upregulating ZO-1 and Occludin, but these improvement effects were lost in pseudogerm-free mice. 16S rRNA sequencing revealed that EA reconfigured the dysbiotic microbiome and selectively expanded barrier-protective genera such as Akkermansia, Muribaculum, Parabacteroides, and Lactobacillus. Transcriptomic analysis indicated that EA regulated cholesterol metabolism and bile secretion. Moreover, EA increased the levels of total bile acids (BAs), secondary BAs, and unconjugated BAs, and the upregulated BAs activated the intestinal farnesoid X receptor. Collectively, these findings provided novel evidence that EA alleviated HFD-induced gut barrier injury.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c16899","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:16:39Z","timestamp":1785849399000},"page":"24263-24276","source":"Crossref","is-referenced-by-count":0,"title":["Multiomics Dissection\nof the Mechanisms Underlying\nEicosapentaenoic Acid Astaxanthin Ester-Mediated Protection Against\nHigh-Fat Diet-Induced Gut Barrier Injury"],"prefix":"10.1021","volume":"74","author":[{"given":"Xiaoran","family":"Li","sequence":"first","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, Shandong, China, 266042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolian","family":"Jing","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, Shandong, China, 266042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsen","family":"Xia","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, Shandong, China, 266042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Duan","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, Shandong, China, 266042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-8593","authenticated-orcid":true,"given":"Tiantian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ocean University of China , , , ,","place":["Qingdao, Shandong, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, Shandong, China, 266042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-6830","authenticated-orcid":true,"given":"Hongxia","family":"Che","sequence":"additional","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, Shandong, China, 266042"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"1","key":"2026081208093987800_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.69","article-title":"New insights into the mechanisms\nof high-fat diet mediated gut microbiota in chronic diseases","volume":"2","author":"Chen","year":"2023","journal-title":"Imeta"},{"issue":"1","key":"2026081208093987800_cit2","doi-asserted-by":"publisher","first-page":"2494703","DOI":"10.1080\/19490976.2025.2494703","article-title":"Gut microbiota and\nassociated metabolites: key players in high-fat diet-induced chronic\ndiseases","volume":"17","author":"Du","year":"2025","journal-title":"Gut Microbes"},{"issue":"5","key":"2026081208093987800_cit3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3390\/antibiotics13050392","article-title":"The Role of Gut\nMicrobiota in the Etiopathogenesis of Multiple Chronic Diseases","volume":"13","author":"Pires","year":"2024","journal-title":"Antibiotics"},{"issue":"5","key":"2026081208093987800_cit4","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.immuni.2025.03.017","article-title":"Acute exposure to high-fat diet impairs ILC3\nfunctions and gut homeostasis","volume":"58","author":"Xiong","year":"2025","journal-title":"Immunity"},{"issue":"20","key":"2026081208093987800_cit5","doi-asserted-by":"publisher","first-page":"11759","DOI":"10.1021\/acs.jafc.4c01595","article-title":"Chlorogenic Acid\/Linoleic\nAcid-Fortified Wheat-Resistant Starch Ameliorates High-Fat Diet-Induced\nGut Barrier Damage by Modulating Gut Metabolism","volume":"72","author":"Guo","year":"2024","journal-title":"J. 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