{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:43:20Z","timestamp":1786538600571,"version":"build-2736575974"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["JYB2025XDXM703"],"award-info":[{"award-number":["JYB2025XDXM703"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1700300"],"award-info":[{"award-number":["2022YFD1700300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["CX (24) 1007"],"award-info":[{"award-number":["CX (24) 1007"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072443"],"award-info":[{"award-number":["32072443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472625"],"award-info":[{"award-number":["32472625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rice bacterial leaf blight (BLB), caused by Xanthomonas oryzae pv. oryzae (Xoo), poses a serious threat to global rice production. Given the critical role of filamentous temperature-sensitive protein Z (FtsZ) in bacterial cell division, thirty-five curcumin derivatives were designed targeting XooFtsZ for combating BLB. Among them, compound B01 exhibited outstanding anti-Xoo activity, with an EC50 value of 3.74 \u03bcg\/mL, significantly outperforming curcumin (41.92 \u03bcg\/mL) and the commercial bactericides bismerthiazol (10.85 \u03bcg\/mL) and thiodiazole copper (10.48 \u03bcg\/mL). In greenhouse trials, B01 achieved 73.2% disease control efficacy against BLB at 200 \u03bcg\/mL, with no obvious phytotoxicity observed on rice plants. Morphological evidence revealed that B01 induced cell elongation, suggesting division inhibition. Molecular interaction assays identified B01\u2032s specific binding to XooFtsZ at the residues LEU71, GLY74, GLY110, and THR111. Furthermore, B01 simultaneously inhibited GTPase activity and disrupted FtsZ polymerization. This work established B01 as a promising XooFtsZ-targeted lead for novel bactericides.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c17072","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:13:10Z","timestamp":1785849190000},"page":"24092-24102","source":"Crossref","is-referenced-by-count":0,"title":["Novel Curcumin Derivatives as Potent FtsZ-Targeting\nBactericides against Rice Bacterial Leaf Blight"],"prefix":"10.1021","volume":"74","author":[{"given":"Jiahao","family":"Wang","sequence":"first","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Qingdao Agricultural University , , , ,","place":["Qingdao, Shandong, P. R. China, 266109"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Gao","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyifan","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]},{"name":"Academy of Agriculture and Forestry Science, Qinghai University , , ,","place":["Xining, P. R. China, 810016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhao","family":"Hu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"He","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. China, 210095"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , ,","place":["Nanjing, P. R. 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Chem."},{"issue":"18","key":"2026081208083871500_cit28","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1021\/bi401356y","article-title":"SB-RA-2001\nInhibits Bacterial Proliferation\nby Targeting FtsZ Assembly","volume":"53","author":"Singh","year":"2014","journal-title":"Biochemistry"},{"issue":"3","key":"2026081208083871500_cit29","doi-asserted-by":"publisher","first-page":"197","DOI":"10.17221\/430\/2015-CJFS","article-title":"Antibacterial Characteristics\nof Orange Pigment Extracted from Monascus Pigments against Escherichia coli","volume":"34","author":"Zhao","year":"2016","journal-title":"Czech. J.\nFood Sci."},{"key":"2026081208083871500_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102548","article-title":"Structure-based drug design with geometric deep learning","volume":"79","author":"Isert","year":"2023","journal-title":"Curr. Opin. Struct. 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