{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:27:13Z","timestamp":1793294833489,"version":"4.5.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Dezhou Modern Industrial Experts Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hemiptera pests damage crops and transmit viruses through piercing\u2013sucking mouthparts, causing enormous economic losses and inducing resistance to insecticides. Novel insecticides are critical to combat rising resistance. Nicotinamidase, a newly validated target present in the insect chordotonal organ, has attracted attention. A series of novel sulfonyl, carbonyl, and amide group-based 4-(trifluoromethyl)nicotinamide derivatives was designed using the prodrug strategy and an intermediate derivatization method. Bioactivity assays indicated that most compounds possessed enhanced insecticidal activity. B-38 exhibited outstanding lethality against Sitobion avenae (LC50 = 0.710 mg\/L), outperforming that of flonicamid (LC50 = 13.7 mg\/L). The 3D-QSAR model revealed that the introduction of electron-withdrawing groups at the R3 position and electron-donating groups at the R4 positions, respectively, enhanced insecticidal potency. DFT calculations suggested that propargyl and imide groups may be essential for bioactivity. This study provides fundamental insights for developing green and efficient insecticides.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c17495","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:25:09Z","timestamp":1784190309000},"page":"22568-22578","source":"Crossref","is-referenced-by-count":1,"title":["Design, Synthesis, and Bioactivities of Novel 4-(Trifluoromethyl)nicotinamide\nDerivatives for Use as Insecticides"],"prefix":"10.1021","volume":"74","author":[{"given":"Ying","family":"Bian","sequence":"first","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]},{"name":"Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansong","family":"Li","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Bo","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghu","family":"Bi","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-6879","authenticated-orcid":true,"given":"Ying","family":"Fu","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]},{"name":"Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-752X","authenticated-orcid":true,"given":"Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University , , ,","place":["Harbin, China, 150030"]},{"name":"Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province , ,","place":["Harbin, China, 150030"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026072910080824300_cit1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.gfs.2016.06.002","article-title":"Reducing Risks\nto Food Security from Climate Change","volume":"11","author":"Campbell","year":"2016","journal-title":"Global\nFood Secur"},{"key":"2026072910080824300_cit2","doi-asserted-by":"publisher","first-page":"106442","DOI":"10.1016\/j.still.2024.106442","article-title":"Challenges and Potential\nPathways towards Sustainable\nAgriculture Crop Production: A Systematic Review to Achieve Sustainable\nDevelopment Goals (SDGs)","volume":"248","author":"Chowdhuri","year":"2025","journal-title":"Soil Tillage Res."},{"key":"2026072910080824300_cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn3747","article-title":"Climate Change Exacerbates the Environmental\nImpacts of Agriculture","volume":"385","author":"Yang","year":"2024","journal-title":"Science."},{"key":"2026072910080824300_cit4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s10905-024-09850-1","article-title":"Tracking the Feeding Mechanism of\nSap-Sucking Insect-Pests through\nElectropenetrography (EPG)","volume":"37","author":"Tayyab","year":"2024","journal-title":"J. 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Food Chem."},{"key":"2026072910080824300_cit31","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1584\/jpestics.D20-069","article-title":"Benzpyrimoxan: Design,\nSynthesis, and Biological Activity\nof a Novel Insecticide","volume":"46","author":"Satoh","year":"2021","journal-title":"J. Pestic. Sci."},{"key":"2026072910080824300_cit32","doi-asserted-by":"publisher","first-page":"9489","DOI":"10.1021\/acs.jafc.4c08476","article-title":"Rational Design and\nSynthesis of Isoxazoline Derivatives with Low\nBee-Toxicity Based on Bee GABA Receptors","volume":"73","author":"Yang","year":"2025","journal-title":"J.\nAgric. Food Chem."},{"key":"2026072910080824300_cit33","doi-asserted-by":"publisher","first-page":"18141","DOI":"10.1021\/acs.jafc.5c01809","article-title":"Design, Synthesis, and Insecticidal\nActivities of Novel Sulfone Derivatives","volume":"73","author":"Hao","year":"2025","journal-title":"J.\nAgric. Food Chem."},{"key":"2026072910080824300_cit34","doi-asserted-by":"publisher","first-page":"14211","DOI":"10.1021\/acs.jafc.3c03459","article-title":"Rational Design\nof Insecticidal Isoxazolines\nContaining Sulfonamide or Sulfinamide Structure as Antagonists of\nGABA Receptors with Reduced Toxicities to Honeybee and Zebrafish","volume":"71","author":"Yang","year":"2023","journal-title":"J. Agric. 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