{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:34:02Z","timestamp":1787150042969,"version":"build-2736575974"},"reference-count":102,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteoporosis, a metabolic bone disorder affecting nearly one-third of women and one-fifth of men globally, poses a major public health burden. Current pharmacological treatments face limitations, driving interest in safer nutritional interventions. The gut\u2013bone axis, through which gut microbiota modulate bone homeostasis, offers a promising target. This review synthesizes recent evidence on probiotics, including both viable and heat-inactivated strains of Lactobacillus and Bifidobacterium, as modulators of osteoporosis. Probiotics exert integrated protective effects by reinforcing intestinal barrier, balancing Th17\/Treg\/Breg immunity, regulating RANKL\/RANK\/OPG signaling, producing short-chain fatty acids, and modulating serotonin metabolism. Preclinical and clinical studies show that specific strains improve bone density and microstructure, though efficacy depends on strain, dosage, duration, and host factors. Moreover, heat-inactivated forms and postbiotics offer stability advantages. Future development of synbiotics, next-generation probiotics, and functional foods tailored to specific matrices, along with personalized strategies, promises effective dietary interventions for bone health.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c17737","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:01:53Z","timestamp":1786348913000},"page":"24717-24736","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Modulation\nof Osteoporosis via Probiotics\nand the Gut\u2013Bone Axis: From Mechanisms to Food Applications"],"prefix":"10.1021","volume":"74","author":[{"given":"Yingyue","family":"Guo","sequence":"first","affiliation":[{"name":"Nanjing University of Finance and Economics\/Collaborative Innovation Center for Modern Grain Circulation and Safety\/State Key Laboratory Incubation and Development Base for Grain Quality Safety and Nutritional Health , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Kuang","sequence":"additional","affiliation":[{"name":"Nanjing University of Finance and Economics\/Collaborative Innovation Center for Modern Grain Circulation and Safety\/State Key Laboratory Incubation and Development Base for Grain Quality Safety and Nutritional Health , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanjing University of Finance and Economics\/Collaborative Innovation Center for Modern Grain Circulation and Safety\/State Key Laboratory Incubation and Development Base for Grain Quality Safety and Nutritional Health , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-3611","authenticated-orcid":true,"given":"Bo","family":"Ren","sequence":"additional","affiliation":[{"name":"Nanjing Normal University , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-9069","authenticated-orcid":true,"given":"Luanfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University of Finance and Economics\/Collaborative Innovation Center for Modern Grain Circulation and Safety\/State Key Laboratory Incubation and Development Base for Grain Quality Safety and Nutritional Health , , ,","place":["Nanjing, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026081910142853200_cit1","doi-asserted-by":"publisher","first-page":"1109296","DOI":"10.3389\/fendo.2023.1109296","article-title":"Effect of Bifidobacterium on osteoclasts: TNF-\u03b1\/NF-\u03baB\ninflammatory signal pathway-mediated\nmechanism","volume":"14","author":"Wu","year":"2023","journal-title":"Front. 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