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CWBP-2-1 is a polysaccharide with a multibranched structure mainly composed of Gal, Man, Glc, and Ara. Its molecular weight is 23.267 kDa. The main chain consists of \u21924)-\u03b2-d-Galp-(1\u2192, \u21922)-\u03b1-d-Manp-(1\u2192, \u21923,6)-\u03b2-d-Galp-(1\u2192, \u21922,6)-\u03b1-d-Galp-(1\u2192, and \u21926)-\u03b2-d-Glcp-(1\u2192. CWBP-2-1 exhibits preventive effects against dextran sodium sulfate (DSS)-induced colitis. It can alleviate tissue damage and inflammatory symptoms of colitis and inhibit the NF-\u03baB signaling pathway. CWBP-2-1 relieved the imbalance in the gut microbiota caused by DSS and inhibited the growth of harmful bacteria. Additionally, metabolomic analysis of the colon and liver indicated that CWBP-2-1 could prevent metabolic disorders caused by DSS-induced colitis in the gut\u2013liver axis. These results suggest that CWBP-2-1 exhibits preventive potential against DSS-induced colitis in mice and may serve as a promising plant-derived polysaccharide for further investigation in intestinal health-related research.<\/jats:p>","DOI":"10.1021\/acs.jafc.5c18008","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:01:22Z","timestamp":1777320082000},"page":"18364-18380","source":"Crossref","is-referenced-by-count":0,"title":["Structural Characterization\nand Deconstruction of\nPolysaccharides from\n                    <i>Chenopodium quinoa<\/i>\n                    Willd. Bran:\nMechanistic Insights into Their Protective Effects against Colitis"],"prefix":"10.1021","volume":"74","author":[{"given":"Wensen","family":"Zhao","sequence":"first","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuolong","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Nan","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangong","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]},{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-5277","authenticated-orcid":true,"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , ,","place":["Taiyuan, China, 030031"]},{"name":"Shanxi Agricultural University , , ,","place":["Taigu, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"10","key":"2026073021160242700_cit1","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative colitis in adults: A Review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"issue":"18","key":"2026073021160242700_cit2","doi-asserted-by":"publisher","first-page":"2101619","DOI":"10.1002\/advs.202101619","article-title":"Colon-targeted adhesive hydrogel\nmicrosphere for regulation of gut immunity and flora","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. 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