{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:17:24Z","timestamp":1788387444688,"version":"build-2803163510"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The suppressive effect of rice albumin (RA) of 16 kDa on elevation of blood glucose level after oral loading of starch or glucose and its possible mechanism were examined. RA suppressed the increase in blood glucose levels in both the oral starch tolerance test and the oral glucose tolerance test. The blood glucose concentrations 15 min after the oral administration of starch were 144 \u00b1 6 mg\/dL for control group and 127 \u00b1 4 mg\/dL for RA 200 mg\/kg BW group, while those after the oral administration of glucose were 157 \u00b1 7 mg\/dL for control group and 137 \u00b1 4 mg\/dL for RA 200 mg\/kg BW group. However, in the intraperitoneal glucose tolerance test, no significant differences in blood glucose level were observed between RA and the control groups, indicating that RA suppresses the glucose absorption from the small intestine. However, RA did not inhibit the activity of mammalian \u03b1-amylase. RA was hydrolyzed to an indigestible high-molecular-weight peptide (HMP) of 14 kDa and low-molecular-weight peptides by pepsin and pancreatin. Furthermore, RA suppressed the glucose diffusion rate through a semipermeable membrane like dietary fibers in vitro. Therefore, the indigestible HMP may adsorb glucose and suppress its absorption from the small intestine.<\/jats:p>","DOI":"10.1021\/acs.jafc.6b00520","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T10:10:11Z","timestamp":1464257411000},"page":"4882-4890","source":"Crossref","is-referenced-by-count":23,"title":["Rice (\n                    <i>Oryza sativa japonica<\/i>\n                    ) Albumin\nSuppresses the Elevation of Blood Glucose and Plasma Insulin Levels\nafter Oral Glucose Loading"],"prefix":"10.1021","volume":"64","author":[{"given":"Shigenobu","family":"Ina","sequence":"first","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mogi","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Hase","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Ando","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Matsukaze","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ogihara","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Akao","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Kyoritsu Women\u2019s University , , 2-2-1 Hitotsubashi , ,","place":["Chiyoda-ku, Tokyo, Japan, 101-8347"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Nihon University , , 1866 Kameino , ,","place":["Fujisawa-shi, Japan, 252-0880"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"2026090218023960700_cit1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.2337\/diacare.21.3.360","article-title":"High blood\nglucose concentration is a risk factor for mortality in middle-aged\nnondiabetic men: 20-year follow-up in the Whitehall study, the Paris\nprospective study, and the Helsinki policemen study","volume":"21","author":"Balkau","year":"1998","journal-title":"Diabetes Care"},{"key":"2026090218023960700_cit2","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1001\/archinte.1994.00420190068008","article-title":"Relationship\nof hyperglycemia to the long-term incidence and progression of diabetic\nretinopathy","volume":"154","author":"Klein","year":"1994","journal-title":"Arch. 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Biochem."},{"key":"2026090218023960700_cit32","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1136\/bmj.1.6124.1392","article-title":"Dietary\nfibres, fibre analogues, and glucose tolerance: importance of viscosity","volume":"1","author":"Jenkins","year":"1978","journal-title":"Br. Med. J."},{"key":"2026090218023960700_cit33","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1124\/pr.108.000604","article-title":"The role of incretins in glucose homeostasis and diabetes\ntreatment","volume":"60","author":"Kim","year":"2008","journal-title":"Pharmacol. 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Nutr."},{"key":"2026090218023960700_cit36","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.peptides.2011.01.002","article-title":"Whey proteins\nas source\nof dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors","volume":"32","author":"Tulipano","year":"2011","journal-title":"Peptides"},{"key":"2026090218023960700_cit37","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00019940","article-title":"Gene structure\nand expression of\nrice seed allergenic proteins belonging to the \u03b1-amylase\/trypsin\ninhibitor family","volume":"21","author":"Adachi","year":"1993","journal-title":"Plant Mol. Biol."},{"key":"2026090218023960700_cit38","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1021\/jf00082a015","article-title":"Structural\nand conformational basis\nof the resistance of \u03b2-lactoglobulin to peptic and chymotryptic\ndigestion","volume":"36","author":"Reddy","year":"1988","journal-title":"J. Agric. 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Int."}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6b00520","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/64\/24\/4882\/67028635\/acs.jafc.6b00520.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/64\/24\/4882\/67028635\/acs.jafc.6b00520.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:02:44Z","timestamp":1788386564000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/64\/24\/4882\/1468543\/Rice-Oryza-sativa-japonica-Albumin-Suppresses-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":48,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2016,5,26]]},"published-print":{"date-parts":[[2016,6,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6b00520","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}