{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:04:33Z","timestamp":1793840673368,"version":"4.6.1"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32572597"],"award-info":[{"award-number":["32572597"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lacto-N-biose (LNB) as the core structure among human milk oligosaccharides remained insufficiently characterized in terms of the potential to ameliorate colitis. This study investigated effects of LNB in colitis by using dextran sulfate sodium salt to induce mouse model. Results demonstrated that LNB significantly ameliorated the increase in disease activity index, suppressed immune factors TNF-\u03b1, F4\/80, IL-6, and IFN-\u03b3, increased factors IL-4 of colitis mice, and the high-dose group exhibited better efficacy. LNB also protected colonic architecture and repairing the intestinal mucosal barrier by facilitating the expression of Muc2, ZO-1, Occludin, and Claudin1. Furthermore, LNB restored gut microbial flora balance by promoting levels of Akkermansia and Lachnospiraceae bacteriumUBA3282 while decreasing Prevotella and Cryptobacteroides. In fecal metabolomics, LNB downregulated the relative content of 7\u03b1-hydroxycholesterol, suggesting that its improvement of colitis may involve bile secretion and primary bile acid biosynthesis pathways. These findings provide new insights for the development and comprehensive utilization of LNB.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c00114","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:17:03Z","timestamp":1780481823000},"page":"17928-17940","source":"Crossref","is-referenced-by-count":2,"title":["Lacto-\n                    <i>N<\/i>\n                    -biose Improves\nAcute Colitis in Mice by Modulating Gut Microbiota and Metabolites"],"prefix":"10.1021","volume":"74","author":[{"given":"Zixin","family":"Fan","sequence":"first","affiliation":[{"name":"Shenyang Agricultural University , , 120 Dongling Road, Shenhe District , ,","place":["Shenyang, China, 110866"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Xie","sequence":"additional","affiliation":[{"name":"Shenyang Agricultural University , , 120 Dongling Road, Shenhe District , ,","place":["Shenyang, China, 110866"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopei","family":"Hu","sequence":"additional","affiliation":[{"name":"Shenyang Agricultural University , , 120 Dongling Road, Shenhe District , ,","place":["Shenyang, China, 110866"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Li","sequence":"additional","affiliation":[{"name":"Shenyang Futhorn Food Technology Co., Ltd , No. 161-3 Zhihui Second Street, Hunnan District , ,","place":["Shenyang, China, 110141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-1838","authenticated-orcid":true,"given":"Motomitsu","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Niigata University , , ,","place":["Niigata, Japan, 950-2181"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-1378","authenticated-orcid":true,"given":"Tuoping","family":"Li","sequence":"additional","affiliation":[{"name":"Shenyang Agricultural University , , 120 Dongling Road, Shenhe District , ,","place":["Shenyang, China, 110866"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenyang Medical College , , ,","place":["Shenyang, China, 110034"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026073021202430000_cit1","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","article-title":"Crohn\u2019s disease","volume":"403","author":"Dolinger","year":"2024","journal-title":"Lancet"},{"key":"2026073021202430000_cit2","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1093\/ibd\/izae081","article-title":"Challenges\nin IBD Research 2024: Preclinical Human IBD Mechanisms","volume":"30","author":"Ciorba","year":"2024","journal-title":"Inflammatory Bowel Dis."},{"key":"2026073021202430000_cit3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00439-023-02521-9","article-title":"The genetics of non-monogenic\nIBD","volume":"142","author":"Jans","year":"2023","journal-title":"Hum. Genet."},{"key":"2026073021202430000_cit4","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1093\/ibd\/izae085","article-title":"Challenges in IBD Research\n2024: Environmental Triggers","volume":"30","author":"Ananthakrishnan","year":"2024","journal-title":"Inflammatory Bowel\nDis."},{"key":"2026073021202430000_cit5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current\nstate of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026073021202430000_cit6","doi-asserted-by":"publisher","first-page":"110441","DOI":"10.1016\/j.abb.2025.110441","article-title":"Dysbiosis of the gut micro-flora\naggravates symptoms and accelerates disease progression in MASLD-IBD\nCo-morbid mice through host-microbial metabolic imbalance","volume":"769","author":"Lin","year":"2025","journal-title":"Arch. Biochem. Biophys."},{"key":"2026073021202430000_cit7","doi-asserted-by":"publisher","first-page":"1073984","DOI":"10.1155\/2023\/1073984","article-title":"Intestinal\nImmune Imbalance is an Alarm in the Development of IBD","volume":"2023","author":"Hu","year":"2023","journal-title":"Mediators Inflammation"},{"key":"2026073021202430000_cit8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1053\/j.gastro.2019.08.060","article-title":"Protein Glycosylation as a Diagnostic\nand Prognostic Marker of Chronic Inflammatory Gastrointestinal and\nLiver Diseases","volume":"158","author":"Verhelst","year":"2020","journal-title":"Gastroenterology"},{"key":"2026073021202430000_cit9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ueg2.12585","article-title":"Treatment\noptions for refractory\nulcerative colitis: Small molecules, big effects","volume":"12","author":"Marafini","year":"2024","journal-title":"United Eur. Gastroenterol. J."},{"key":"2026073021202430000_cit10","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S2468-1253(23)00154-1","article-title":"Difficult-to-treat inflammatory bowel\ndisease: results from an international consensus meeting","volume":"8","author":"Parigi","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"2026073021202430000_cit11","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/glycob\/cws074","article-title":"Human milk\noligosaccharides: every baby needs a sugar mama","volume":"22","author":"Bode","year":"2012","journal-title":"Glycobiology"},{"key":"2026073021202430000_cit12","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/nu15081845","article-title":"2\u2032-Fucosyllactose\nand 3-Fucosyllactose Alleviates Interleukin-6-Induced Barrier Dysfunction\nand Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal\nBarrier Function and Modulating the Intestinal Microbiome","volume":"15","author":"Kim","year":"2023","journal-title":"Nutrients"},{"key":"2026073021202430000_cit13","doi-asserted-by":"publisher","first-page":"102236","DOI":"10.1016\/j.isci.2021.102236","article-title":"Lacto-N-biose synthesis\nvia a modular enzymatic cascade with ATP\nregeneration","volume":"24","author":"Du","year":"2021","journal-title":"iScience"},{"key":"2026073021202430000_cit14","doi-asserted-by":"publisher","first-page":"422S","DOI":"10.3945\/an.111.001420","article-title":"Bifidobacterial\nenzymes involved in the metabolism of human milk oligosaccharides","volume":"3","author":"Kitaoka","year":"2012","journal-title":"Adv. Nutr."},{"key":"2026073021202430000_cit15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1914377","article-title":"Infant gut microbiota\nmodulation by human milk disaccharides in humanized microbiome mice","volume":"13","author":"Rubio-Del-Campo","year":"2021","journal-title":"Gut Microbes"},{"key":"2026073021202430000_cit16","doi-asserted-by":"publisher","first-page":"11845","DOI":"10.1038\/s41598-020-68718-4","article-title":"Human milk and mucosa-associated disaccharides impact\non cultured infant fecal microbiota","volume":"10","author":"Rubio-Del-Campo","year":"2020","journal-title":"Sci. Rep."},{"key":"2026073021202430000_cit17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.12938\/bmfh.31.47","article-title":"Effect of Lacto-N-biose\nI on the Antigen-specific Immune Responses of Splenocytes","volume":"31","author":"Goto","year":"2012","journal-title":"Biosci. Microbiota Food Health"},{"key":"2026073021202430000_cit18","doi-asserted-by":"publisher","first-page":"106111","DOI":"10.1016\/j.fbio.2025.106111","article-title":"Inflammatory modulation effects of\nhuman milk oligosaccharides: From screening in-vitro to application\nin the milk powders","volume":"65","author":"Tang","year":"2025","journal-title":"Food Biosci."},{"key":"2026073021202430000_cit19","doi-asserted-by":"publisher","first-page":"4511","DOI":"10.1111\/ijfs.16337","article-title":"In vitro digestion\nand fermentation\nof lacto-N-biose, a core building block of human milk oligosaccharides","volume":"58","author":"Xie","year":"2023","journal-title":"Int. J. Food Sci. Technol."},{"key":"2026073021202430000_cit20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10930-017-9754-6","article-title":"Expression\nand Characterization of Recombinant Sucrose Phosphorylase","volume":"37","author":"Zhang","year":"2018","journal-title":"Protein J."},{"key":"2026073021202430000_cit21","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1271\/bbb.70320","article-title":"Practical preparation\nof lacto-N-biose I, a candidate\nfor the bifidus factor in human milk","volume":"71","author":"Nishimoto","year":"2007","journal-title":"Biosci.,\nBiotechnol., Biochem."},{"issue":"6","key":"2026073021202430000_cit22","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5717","article-title":"Scientific Opinion on the safety of 2\u2032-fucosyllactose\/difucosyllactose\nmixture as a novel food pursuant to Regulation (EU) 2015\/2283","volume":"17","author":"Turck","year":"2019","journal-title":"EFSA J."},{"issue":"4","key":"2026073021202430000_cit23","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1002\/hep.30361","article-title":"Intestinal Microbiota\nMediates the\nSusceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron\nGeneration in Mice","volume":"69","author":"Gong","year":"2019","journal-title":"Hepatology"},{"key":"2026073021202430000_cit24","doi-asserted-by":"publisher","first-page":"134216","DOI":"10.1016\/j.ijbiomac.2024.134216","article-title":"Exploring the anti-inflammatory effects\nof postbiotic proteins from Lactobacillus delbrueckii CIDCA 133 on\ninflammatory bowel disease model","volume":"277","author":"Freitas","year":"2024","journal-title":"Int. J. Biol.\nMacromol."},{"issue":"11","key":"2026073021202430000_cit25","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/microorganisms8111715","article-title":"The Influence\nof Probiotics on the\nFirmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory\nBowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"2026073021202430000_cit26","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41575-023-00854-4","article-title":"Deciphering the different phases\nof preclinical inflammatory bowel\ndisease","volume":"21","author":"Rudbaek","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026073021202430000_cit27","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3892\/etm.2020.8946","article-title":"Histological\nand ultrastructural changes of the colon in dextran\nsodium sulfate-induced mouse colitis","volume":"20","author":"Xu","year":"2020","journal-title":"Exp. Ther.\nMed."},{"key":"2026073021202430000_cit28","doi-asserted-by":"publisher","first-page":"107597","DOI":"10.1016\/j.intimp.2021.107597","article-title":"Causative\nrole of mast cell and mast cell-regulatory function of disialyllacto-N-tetraose\nin necrotizing enterocolitis","volume":"96","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"2026073021202430000_cit29","doi-asserted-by":"publisher","first-page":"123862","DOI":"10.1016\/j.ijbiomac.2023.123862","article-title":"Orchestration of MUC2\n\u2013 The key regulatory target of gut barrier and homeostasis:\nA review","volume":"236","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"2026073021202430000_cit30","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1093\/ecco-jcc\/jjaa015","article-title":"In-Depth Study of Transmembrane Mucins\nin Association with Intestinal\nBarrier Dysfunction During the Course of T Cell Transfer and DSS-Induced\nColitis","volume":"14","author":"Breugelmans","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"2026073021202430000_cit31","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3390\/toxins13110758","article-title":"Intestinal\nBarrier,\nClaudins and Mycotoxins","volume":"13","author":"Kozie\u0142","year":"2021","journal-title":"Toxins"},{"key":"2026073021202430000_cit32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41575-020-00399-w","article-title":"The intestinal barrier, an arbitrator turned provocateur\nin IBD","volume":"18","author":"Mehandru","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026073021202430000_cit33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1142\/S0192415X24500514","article-title":"Natural Products\non Inflammatory Bowel Disease: Role of Gut Microbes","volume":"52","author":"Cheng","year":"2024","journal-title":"Am. J. Chin. Med."},{"issue":"4","key":"2026073021202430000_cit34","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1053\/j.gastro.2023.01.002","article-title":"F4\/80+Ly6Chigh Macrophages\nLead to Cell Plasticity and Cancer Initiation in Colitis","volume":"164","author":"Shin","year":"2023","journal-title":"Gastroenterology"},{"key":"2026073021202430000_cit35","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.2165\/00003495-200666160-00002","article-title":"Anti-tumour\nnecrosis factor therapy\nfor ulcerative colitis: evidence to date","volume":"66","author":"Thukral","year":"2006","journal-title":"Drugs"},{"key":"2026073021202430000_cit36","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41419-020-02788-0","article-title":"IFN-\u03b3 promoted\nexosomes from mesenchymal stem cells to attenuate\ncolitis via miR-125a and miR-125b","volume":"11","author":"Yang","year":"2020","journal-title":"Cell Death\nDis."},{"key":"2026073021202430000_cit37","doi-asserted-by":"publisher","first-page":"115976","DOI":"10.1016\/j.biopha.2023.115976","article-title":"Polysaccharides\nregulate Th1\/Th2 balance: A new strategy for tumor immunotherapy","volume":"170","author":"Shang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"2026073021202430000_cit38","doi-asserted-by":"publisher","first-page":"115690","DOI":"10.1016\/j.jep.2022.115690","article-title":"Xianglian Pill attenuates ulcerative\ncolitis through TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"300","author":"Dai","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"31","key":"2026073021202430000_cit39","doi-asserted-by":"publisher","first-page":"44138","DOI":"10.1021\/acsami.5c07250","article-title":"Multiomics Reveals Nonphagocytosable\nMicroplastics Induce Colon Inflammatory Injury via Bile Acid-Gut Microbiota\nInteractions and Barrier Dysfunction","volume":"17","author":"Chen","year":"2025","journal-title":"ACS Appl.\nMater. Interfaces"},{"key":"2026073021202430000_cit40","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s00203-023-03570-4","article-title":"Adherent-invasive\nEscherichia coli LF82 aggravated intestinal inflammation in colitis\nmice by affecting the gut microbiota and Th17\/Treg cell differentiation\nbalance","volume":"205","author":"Sha","year":"2023","journal-title":"Arch. Microbiol."},{"key":"2026073021202430000_cit41","doi-asserted-by":"publisher","first-page":"104074","DOI":"10.1016\/j.jff.2020.104074","article-title":"Human milk oligosaccharides:\nShaping the infant gut microbiota and supporting health","volume":"72","author":"Walsh","year":"2020","journal-title":"J. Funct. Foods"},{"key":"2026073021202430000_cit42","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/s41564-021-01050-3","article-title":"Multi-omics analyses\nof the ulcerative colitis gut microbiome link Bacteroides vulgatus\nproteases with disease severity","volume":"7","author":"Mills","year":"2022","journal-title":"Nat. Microbiol."},{"issue":"Supplement_1","key":"2026073021202430000_cit43","doi-asserted-by":"publisher","first-page":"82.19","DOI":"10.4049\/jimmunol.210.Supp.82.19","article-title":"Role of\nBacteroides acidifaciens in gut inflammation during colitis","volume":"210","author":"Staley","year":"2023","journal-title":"J. Immunol."},{"key":"2026073021202430000_cit44","doi-asserted-by":"publisher","first-page":"976239","DOI":"10.3389\/fmicb.2022.976239","article-title":"The effect of tuina on ulcerative colitis model mice analyzed by\ngut microbiota and proteomics","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"issue":"1","key":"2026073021202430000_cit45","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1146\/annurev-micro-051524-032131","article-title":"The biology\nof Akkermansia","volume":"79","author":"Hughes","year":"2025","journal-title":"Annu. Rev.\nMicrobiol."},{"key":"2026073021202430000_cit46","doi-asserted-by":"publisher","first-page":"147789","DOI":"10.1016\/j.ijbiomac.2025.147789","article-title":"Sanghuangporus\nvaninii polysaccharides\nattenuate ovalbumin-induced allergic rhinitis in mice by improving\nthe Th1\/Th2 lymphocyte balance","volume":"329","author":"Wang","year":"2025","journal-title":"Int. J. Biol.\nMacromol."},{"key":"2026073021202430000_cit47","doi-asserted-by":"publisher","first-page":"1278582","DOI":"10.3389\/fcimb.2023.1278582","article-title":"Isolation,\nidentification, and significance\nof salivary Veillonella spp., Prevotella spp., and Prevotella salivae\nin patients with inflammatory bowel disease","volume":"13","author":"Hammad","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026073021202430000_cit48","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/imm.13672","article-title":"Effect of gut flora\nmediated-bile acid metabolism on intestinal immune microenvironment","volume":"170","author":"Zhang","year":"2023","journal-title":"Immunology"},{"key":"2026073021202430000_cit49","doi-asserted-by":"publisher","first-page":"i1186","DOI":"10.1093\/ecco-jcc\/jjae190.0770","article-title":"P0596 Fecal bile acids\npredict the therapeutic effect of biological agents in patients with\nulcerative colitis","volume":"19","author":"Guo","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"2026073021202430000_cit50","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1007\/s10620-024-08485-8","article-title":"Active Inflammatory\nBowel Disease Is Associated with Short Sleep Duration via Objective\nMeasures","volume":"69","author":"Barnes","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"2026073021202430000_cit51","doi-asserted-by":"publisher","first-page":"132057","DOI":"10.1016\/j.jhazmat.2023.132057","article-title":"Adverse effect of\noxidized cholesterol exposure on colitis is mediated by modulation\nof gut microbiota","volume":"459","author":"Yan","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"4","key":"2026073021202430000_cit52","doi-asserted-by":"publisher","first-page":"115397","DOI":"10.1016\/j.isci.2026.115397","article-title":"Circadian disruption exacerbates\nMASH by reducing Akkermansia\nmuciniphila via the FXR-CYP7A1-bile acid axis","volume":"29","author":"Xue","year":"2026","journal-title":"iScience"},{"issue":"4","key":"2026073021202430000_cit53","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids\nand the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c00114","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/23\/17928\/66263292\/acs.jafc.6c00114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/23\/17928\/66263292\/acs.jafc.6c00114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:20:26Z","timestamp":1785460826000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/23\/17928\/5232956\/Lacto-N-biose-Improves-Acute-Colitis-in-Mice-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":53,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2026,6,3]]},"published-print":{"date-parts":[[2026,6,17]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c00114","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]}}}