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In this study, a novel homogeneous polysaccharide, PSLP-1 (4.287 kDa), was isolated and identified as a fructan-rich fraction with a \u21921)-\u03b2-d-Fruf-(2\u2192 backbone and C6 side-chain substitution. In a chronic restraint stress mouse model, PSLP-1 showed clear antidepressant-like activity by reducing immobility time in both the forced swim and tail suspension tests. PSLP-1 was also associated with restoration of tryptophan metabolism, characterized by suppression of the indoleamine 2,3-dioxygenase 1-mediated kynurenine pathway and promotion of tryptophan hydroxylase-related 5-hydroxytryptamine synthesis. These effects were accompanied by gut microbiota remodeling, including increased Akkermansia and decreased Lactobacillus and Alistipes. These findings support P. sibiricum stems and leaves as a promising source of bioactive polysaccharides.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c00317","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:34:51Z","timestamp":1780047291000},"page":"18381-18395","source":"Crossref","is-referenced-by-count":1,"title":["Polysaccharide\nPSLP-1 from\n                    <i>Polygonatum sibiricum<\/i>\n                    Stems and Leaves Alleviates Depressive-like\nBehaviors and Modulates Gut Microbiota and Tryptophan Metabolism along\nthe Gut\u2013Brain Axis"],"prefix":"10.1021","volume":"74","author":[{"given":"Junyuan","family":"Huang","sequence":"first","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebin","family":"Zou","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Qian","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Su","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensong","family":"Sun","sequence":"additional","affiliation":[{"name":"Liaoning Institute of Cash Crops , ,","place":["Liaoyang, China, 111000"]},{"name":"Liaoning Academy of Agricultural Sciences , , ,","place":["Shenyang, China, 111000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Hong Kong , , , ,","place":["Pokfulam, Hong Kong, China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1669-3094","authenticated-orcid":true,"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-1067","authenticated-orcid":true,"given":"Bing","family":"Du","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8106-8581","authenticated-orcid":true,"given":"Pan","family":"Li","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"2026073021201636400_cit1","doi-asserted-by":"publisher","first-page":"109678","DOI":"10.1016\/j.pnpbp.2019.109678","article-title":"Major depressive\ndisorders accompanying autoimmune diseases \u2013 Response to treatment","volume":"95","author":"Bialek","year":"2019","journal-title":"Prog. 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