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LZUC-S1 using a bioactivity-guided isolation. Their chemical structures were elucidated through an integrated analysis of IR, NMR, and HRESIMS data, and verified by crystallography and degradative experiments. Compounds 1\u20137 represent the first reported instance of phenyl ribosides. The phytotoxic potency of the purified metabolites was assessed against seedlings of Chloris virgata and Portulaca oleracea. The results demonstrated that phenyl-O-\u03b2-d-ribofuranoside derivatives showed higher herbicidal activity than naphthalenones. Notably, compounds 1 and 2 demonstrated potent herbicidal activity against both weed species at 100 mg\/L, exhibiting efficacy superior to the commercial herbicide glyphosate at the same concentration. Preliminary mechanism studies indicated that the phenyl-O-\u03b2-D-ribofuranoside derivatives probably exert their herbicidal effect by disrupting energy metabolism, specifically through the inhibition \u03b1-amylase functionality. These findings expand the structural diversity of phenolic glycosides and offer valuable leads for developing new fungal-derived herbicides.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c00320","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:09Z","timestamp":1789628529000},"page":"30113-30124","source":"Crossref","is-referenced-by-count":0,"title":["Phenyl-\n                    <i>O<\/i>\n                    -\u03b2-\n                    <scp>d<\/scp>\n                    -ribofuranoside\nDerivatives from the Plant Endophytic\nFungus\n                    <i>Neofusicoccum<\/i>\n                    sp. LZUC-S1 and Their Herbicidal\nActivity"],"prefix":"10.1021","volume":"74","author":[{"given":"Xiao-Xu","family":"Ji","sequence":"first","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, People\u2019s Republic of China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jing","family":"Fu","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, People\u2019s Republic of China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, People\u2019s Republic of China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, People\u2019s Republic of China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, People\u2019s Republic of China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-6586","authenticated-orcid":true,"given":"Shujie","family":"Ma","sequence":"additional","affiliation":[{"name":"Hebei Agricultural University , , ,","place":["Baoding, People\u2019s Republic of China, 071001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Yu","sequence":"additional","affiliation":[{"name":"Gansu Academy of Agricultural Sciences , , ,","place":["Lanzhou, People\u2019s Republic of China, 730070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-5569","authenticated-orcid":true,"given":"Jian-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, People\u2019s Republic of China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"4","key":"2026093009072749900_cit1","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/padr.12508","article-title":"Rethinking Global Food Demand for\n2050","volume":"48","author":"Falcon","year":"2022","journal-title":"Popul. 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Environ.\nSci. Technol."},{"issue":"24","key":"2026093009072749900_cit5","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16245129","article-title":"A Review on\nRecent Treatment Technology for Herbicide Atrazine in Contaminated\nEnvironment","volume":"16","author":"He","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"2026093009072749900_cit6","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1002\/ps.6285","article-title":"Where Are the New Herbicides?","volume":"77","author":"Qu","year":"2021","journal-title":"Pest Manage. Sci."},{"key":"2026093009072749900_cit7","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1040901","article-title":"Biopesticides\nas a Promising Alternative to Synthetic\nPesticides: A Case for Microbial Pesticides, Phytopesticides, and\nNanobiopesticides","volume":"14","author":"Ayilara","year":"2023","journal-title":"Front. 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