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In this study, an arabinogalactan, PG-2, was isolated and purified from PG. The structural and physicochemical properties of PG-2 were analyzed. The efficacy of PG-2 in alleviating constipation and its effects on gut microbiota, its metabolites, colonic 5-HT production, and 5-HT-mediated signaling pathways were evaluated using a humanized aging constipation model. PG-2 has a molecular weight of 3185.2 kDa, with (1\u21923,6)-linked \u03b2-d-galactosyl and (1\u21925)-linked \u03b1-l-arabinosyl residues as the major residues. PG-2 exhibits a loose mesh-like structure with shear thinning, thermal stability, water-binding ability, and moderate surface activity. PG-2 was found to enhance the abundance of gut microbiota like Ruminococcus and facilitate the production of tryptophan metabolites like tryptamine, which activates the gut 5-HT signaling pathway, thereby alleviating elderly constipation. In summary, PG-2 represents a promising functional food or an active ingredient for protecting the gastrointestinal tract.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c00384","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:02:27Z","timestamp":1786201347000},"page":"25164-25182","source":"Crossref","is-referenced-by-count":0,"title":["Structural Characterization, Physicochemical Properties,\nand Ameliorating Effect on Age-Related Constipation of an Arabinogalactan\nfrom Peach Gum"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-4040","authenticated-orcid":true,"given":"Jingyan","family":"Guo","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Mao","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-813X","authenticated-orcid":true,"given":"Jianjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Jin","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengpu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Gan","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqiu","family":"Yan","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , , ,","place":["Hangzhou, China, 310053"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"issue":"4","key":"2026081910152602600_cit1a","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1096\/fj.14-259598","article-title":"Gut microbes\npromote colonic serotonin\nproduction through an effect of short-chain fatty acids on enterochromaffin\ncells","volume":"29","author":"Reigstad","year":"2015","journal-title":"FASEB J."},{"key":"2026081910152602600_cit1b","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3389\/fmicb.2016.00345","article-title":"Gut Microbiota: The Brain Peacekeeper","volume":"7","author":"Mu","year":"2016","journal-title":"Front. 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