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Carnosol, a rosemary-derived diterpene with antioxidant properties, was investigated for its therapeutic potential in tissue repair. Carnosol pretreatment protected HaCaT keratinocytes from oxidative injury by enhancing viability, reducing reactive oxygen species and apoptosis, and promoting migration. Network pharmacology identified the Keap1-Nrf2\/HO-1 axis as a candidate pathway; molecular dynamics simulations predicted and surface plasmon resonance demonstrated direct carnosol\u2013Keap1 binding. Nrf2 silencing, HO-1 inhibition, or Keap1 overexpression attenuated carnosol\u2019s protective effects. Mechanistically, carnosol-induced HO-1 restored DRP1-mediated mitochondrial fission and PINK1-Parkin-dependent mitophagy, maintaining mitochondrial homeostasis via mitochondrial quality control. In vivo, topical carnosol accelerated wound closure, improved histological repair, and upregulated Nrf2\/HO-1 in a mouse pressure ulcer model, with superior histological and angiogenic outcomes versus intraperitoneal delivery. Carnosol facilitates pressure ulcer healing via Nrf2\/HO-1-driven mitochondrial quality control, supporting development as a topical therapeutic candidate.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c00594","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:02:54Z","timestamp":1788764574000},"page":"28395-28407","source":"Crossref","is-referenced-by-count":0,"title":["Carnosol Accelerates\nPressure Ulcer Healing via Keap1-Nrf2\/HO-1-Mediated\nMitochondrial Quality Control"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5118-2035","authenticated-orcid":true,"given":"Sheng","family":"Dong","sequence":"first","affiliation":[{"name":"Suzhou Medical College of Soochow University , , ,","place":["Suzhou, Jiangsu, China, 215123"]},{"name":"Wuxi No. 9 People\u2019s Hospital Affiliated to Soochow University , , , ,","place":["Wuxi, Jiangsu, China, 214062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-8016","authenticated-orcid":true,"given":"Xin","family":"Ge","sequence":"additional","affiliation":[{"name":"Wuxi No. 9 People\u2019s Hospital Affiliated to Soochow University , , , ,","place":["Wuxi, Jiangsu, China, 214062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5262-8174","authenticated-orcid":true,"given":"Xinyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Wuxi No. 9 People\u2019s Hospital Affiliated to Soochow University , , , ,","place":["Wuxi, Jiangsu, China, 214062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8327-2301","authenticated-orcid":true,"given":"Jian","family":"Meng","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University , , ,","place":["Suzhou, Jiangsu, China, 215123"]},{"name":"Xuzhou Central Hospital , , , ,","place":["Xuzhou, Jiangsu, China, 221009"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"2","key":"2026091609091664400_cit1","doi-asserted-by":"publisher","first-page":"Cd003216","DOI":"10.1002\/14651858.CD003216.pub3","article-title":"Nutritional interventions for preventing and treating\npressure ulcers","volume":"2","author":"Langer","year":"2024","journal-title":"Cochrane Database Syst. 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