{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:11:53Z","timestamp":1778058713803,"version":"3.51.4"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011074"],"award-info":[{"award-number":["2024A1515011074"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304338"],"award-info":[{"award-number":["82304338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhanjiang Marine Young Talent Innovation Project","award":["2023E0007"],"award-info":[{"award-number":["2023E0007"]}]},{"name":"Economic Development of Marine Economy of Guangdong Province, China","award":["GDNRC[2022]38"],"award-info":[{"award-number":["GDNRC[2022]38"]}]},{"name":"Guangdong Provincial University Characteristic Innovation Project","award":["2023KTSCX035"],"award-info":[{"award-number":["2023KTSCX035"]}]},{"name":"Guangdong Medical University","award":["GDMUZDCG25023"],"award-info":[{"award-number":["GDMUZDCG25023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2026,5,6]]},"DOI":"10.1021\/acs.jafc.6c00728","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:58:27Z","timestamp":1777316307000},"page":"13672-13686","source":"Crossref","is-referenced-by-count":0,"title":["Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from\n                    <i>Miichthys miiuy<\/i>\n                    Fish Maw Alleviate Insulin Resistance Via Regulating the PPAR\u03b3-Driven IRS1\/PI3K\/AKT Signaling Pathway"],"prefix":"10.1021","volume":"74","author":[{"given":"Xingyan","family":"Li","sequence":"first","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Feng","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Huang","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siying","family":"Feng","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changchun","family":"Li","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Ouyang","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengliang","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samad","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang)","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghua","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4304-6350","authenticated-orcid":true,"given":"Luming","family":"Deng","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]},{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefeng","family":"Wu","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]},{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources","place":["Zhanjiang, China"]},{"name":"Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105897"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117892"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1857683"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/983814"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/970375"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.10.018"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c05900"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157003"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043940"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169059"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2022.06.001"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111738"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140925"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145751"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105126"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2025.106724"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2022.2034895"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104548"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2024.104345"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126460"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2020.100748"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/md19100584"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107515"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-90011-5"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.143314"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.117749"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.138"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c12660"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.06.017"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065195"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13279"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.06.014"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/md20050325"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2022.27.2.172"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/md16050161"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/bf03350807"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02873-5"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.05.067"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020392"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/md21030169"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116306"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1172\/jci151818"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3128-1"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32348-3"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-021-01498-3"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106850"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1714482"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154862"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154634"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117132"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5055.379"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28415"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0436"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155743"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154740"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-173716"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00513.2004"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030064"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01717-2"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2644-8"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1373711"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-024-01485-2"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2023.07.006"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3390\/ani11010054"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2024.0154"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c00728","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c00728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:14:57Z","timestamp":1778055297000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.6c00728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":65,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5,6]]}},"alternative-id":["10.1021\/acs.jafc.6c00728"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c00728","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}