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Therefore, an edible nanodelivery system composed of a zein\/citric acid complex was developed to encapsulate Res@ZC-NPs showed high encapsulation efficiency, average particle size of 66.16 \u00b1 1.19 nm and PDI of 0.176. In vitro, ZC-NPs inhibited oxidative stress-induced reactive oxygen species production and promoted cellular uptake. In vivo, the nanoparticles effectively delivered res to the colon, prolonged its retention, alleviate dextran sulfate sodium (DSS)-induced colitis in mice, preserve colonic tissue integrity, restore intestinal barrier function, and partially reshape gut microbiota composition. Overall, this study developed an oral nanosystem based on natural edible materials, providing an ideal delivery strategy for plant polyphenol-based active ingredients in treating ulcerative colitis.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c00836","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T21:01:37Z","timestamp":1786136497000},"page":"25202-25219","source":"Crossref","is-referenced-by-count":0,"title":["Oral Edible Zein\/Citric\nAcid Nanocomposite Enables\nIntestinal Delivery of Resveratrol for Effective Ulcerative Colitis\nTherapy"],"prefix":"10.1021","volume":"74","author":[{"given":"Jun","family":"Zhao","sequence":"first","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province , ,","place":["Chengdu, China, 611137"]},{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 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