{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:48:16Z","timestamp":1782290896330,"version":"3.54.5"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2027,6,10]],"date-time":"2027-06-10T00:00:00Z","timestamp":1812585600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515011795"],"award-info":[{"award-number":["2025A1515011795"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012487"],"award-info":[{"award-number":["2025A1515012487"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012645"],"award-info":[{"award-number":["2025A1515012645"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021TQ0126"],"award-info":[{"award-number":["2021TQ0126"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21625111"],"award-info":[{"award-number":["21625111"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["25625214"],"award-info":[{"award-number":["25625214"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pearl River Innovation and Entrepreneurship Team","award":["2021ZT09Y552"],"award-info":[{"award-number":["2021ZT09Y552"]}]},{"name":"Key Laboratory of Viral Pathogenesis and Infection Prevention and Control of the Ministry of Education","award":["2024VPPC-R07"],"award-info":[{"award-number":["2024VPPC-R07"]}]},{"name":"Key Laboratory of Viral Pathogenesis and Infection Prevention and Control of the Ministry of Education","award":["2025VPPC-R05"],"award-info":[{"award-number":["2025VPPC-R05"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["82304571"],"award-info":[{"award-number":["82304571"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["82350710801"],"award-info":[{"award-number":["82350710801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Agric. Food Chem."],"published-print":{"date-parts":[[2026,6,24]]},"DOI":"10.1021\/acs.jafc.6c01060","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:43:26Z","timestamp":1781142206000},"page":"18723-18740","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of 10-Shogaol from\n                    <i>Zingiber officinale<\/i>\n                    with Broad Antiviral and Anti-inflammatory Activity against Dengue and Zika Viruses Using Activity-Guided Molecular Networking"],"prefix":"10.1021","volume":"74","author":[{"given":"Mengxue","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-5010","authenticated-orcid":true,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]},{"name":"Key Laboratory of Viral Pathogenesitables & Infection Prevention and Control","place":["Guangzhou, China"]},{"name":"(Jinan University), Ministry of Education","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy","place":["Guangzhou, China"]},{"name":"Jinan University Affiliated Guangdong Second General Provincial Hospital","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biosafety Level 3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, Key Laboratory of Infectious Diseases Research in South China, School of Public Health","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]},{"name":"Key Laboratory of Viral Pathogenesitables & Infection Prevention and Control","place":["Guangzhou, China"]},{"name":"(Jinan University), Ministry of Education","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6415-7299","authenticated-orcid":true,"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology, School of Medicine","place":["Guangzhou, China"]},{"name":"Jinan University","place":["Guangzhou, China"]},{"name":"Key Laboratory of Viral Pathogenesitables & Infection Prevention and Control","place":["Guangzhou, China"]},{"name":"(Jinan University), Ministry of Education","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0476-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s43247-024-01639-6"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02576-X"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix766"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12070770"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00522-3"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nature02165"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832193100"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.05.011"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3863"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12748"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00489"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-024-00969-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b03600"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.112589"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153317"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c07138"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.22146\/ijbiotech.60174"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136343"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.03.050"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.2478\/bile-2024-0008"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s10260-010-0142-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00214A"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111518"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-020-01079-z"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.12.002"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3390\/v14112575"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060571"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122345"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01551-20"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/tx500211x"}],"container-title":["Journal of Agricultural and Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c01060","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c01060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:12:16Z","timestamp":1782288736000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.6c01060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":32,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,6,24]]}},"alternative-id":["10.1021\/acs.jafc.6c01060"],"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c01060","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]}}}