{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:16:17Z","timestamp":1788455777767,"version":"build-2803163510"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["25JCYBJC00460"],"award-info":[{"award-number":["25JCYBJC00460"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Plant diseases continuously threaten crop yield and quality. Given the overuse of chemical agents, developing antiviral and fungicidal agents from natural products represents a promising sustainable strategy. In this study, a series of raspberry ketone derivatives were designed, synthesized, and evaluated for their antiviral and fungicidal activities. Most compounds exhibited better antiviral activity than ribavirin; in particular, compounds 3iand 5h\u20135j showed significantly higher antiviral activity (EC50: 144\u2013199 \u03bcg\/mL) than ningnanmycin (EC50: 235 \u03bcg\/mL) and thus emerged as novel antiviral candidates. Compound 3i was chosen for antiviral action mechanism research, which revealed that it can cause 20S coat protein (CP) polymerization, thereby affecting the assembly of TMV particles. The results of molecular docking and DFT calculations further provided a molecular basis for the observed antiviral activity. Additionally, these compounds displayed broad-spectrum fungicidal activity against six plant pathogens and met pesticide-likeness criteria in ADME predictions. This research advances the development of raspberry ketone derivatives as green pesticides.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01173","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:59:18Z","timestamp":1787392758000},"page":"26982-26991","source":"Crossref","is-referenced-by-count":0,"title":["Scaffold Hopping\nfor Pesticide Discovery: Design,\nSynthesis, and Biological Activity Research of Novel Raspberry Ketone\nDerivatives"],"prefix":"10.1021","volume":"74","author":[{"given":"Zhiting","family":"Zhao","sequence":"first","affiliation":[{"name":"Tianjin Normal University , , ,","place":["Tianjin, China, 300387"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Tianjin Normal University , , ,","place":["Tianjin, China, 300387"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Normal University , , ,","place":["Tianjin, China, 300387"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Normal University , , ,","place":["Tianjin, China, 300387"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Normal University , , ,","place":["Tianjin, China, 300387"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikai","family":"Niu","sequence":"additional","affiliation":[{"name":"Shandong University of Technology , , ,","place":["Zibo, China, 255000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-4236","authenticated-orcid":true,"given":"Zhenghong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-3766","authenticated-orcid":true,"given":"Qingmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-7021","authenticated-orcid":true,"given":"Ziwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Normal University , , ,","place":["Tianjin, China, 300387"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"2026090311495074600_cit1","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.3390\/plants12223822","article-title":"Why do we\nneed alternative methods for fungal disease management in plants?","volume":"12","author":"Mclaughlin","year":"2023","journal-title":"Plants"},{"key":"2026090311495074600_cit2","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cj.2024.01.007","article-title":"OsWRKY65 enhances\nimmunity against\nfungal and bacterial pathogens in rice","volume":"12","author":"Son","year":"2024","journal-title":"Crop\nJ."},{"key":"2026090311495074600_cit3","doi-asserted-by":"publisher","first-page":"118117","DOI":"10.1016\/j.eswa.2022.118117","article-title":"Trends in vision-based\nmachine learning techniques for plant disease identification: A systematic\nreview","volume":"208","author":"Thakur","year":"2022","journal-title":"Expert Syst. 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