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Transcriptomics and molecular docking revealed that S4286 potential targets the mitochondrial division protein (Mdp1) with high affinity. Subsequent functional assays indicated that S4286 triggers mitochondrial dysfunction, characterized by structural damage, loss of membrane potential, reactive oxygen species (ROS) burst, and ATP depletion. Our findings reveal a novel mechanism involving mitochondrial dysfunction and highlight S4286 as a promising lead for developing next-generation fungicides to manage resistance.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01214","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:20:04Z","timestamp":1785849604000},"page":"24136-24148","source":"Crossref","is-referenced-by-count":0,"title":["Natural Product Echinocandin Derivative S4286 Induces\nMitochondrial Dysfunction to Combat\n                    <i>Sclerotinia sclerotiorum<\/i>"],"prefix":"10.1021","volume":"74","author":[{"given":"Genglin","family":"Zhu","sequence":"first","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Duan","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Baicheng Academy of Agricultural Sciences , ,","place":["Baicheng, China, 137000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3205-3345","authenticated-orcid":true,"given":"Wenli","family":"Jiao","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zuo","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Lv","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5605-5380","authenticated-orcid":true,"given":"Hongyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-5939","authenticated-orcid":true,"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"2026081208073722800_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1364-3703.2005.00316.x","article-title":"Sclerotinia sclerotiorum (Lib.) de Bary: biology and molecular traits of a cosmopolitan pathogen","volume":"7","author":"Bolton","year":"2006","journal-title":"Mol. 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