{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:41Z","timestamp":1792590401300,"version":"4.5.0"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A series of racemic pyrazole-4-carboxamide and aromatic carboxamide derivatives bearing a trans-2-(trifluoromethyl)cyclopropyl moiety were designed and synthesized as potential succinate dehydrogenase inhibitors (SDHIs). The compounds were evaluated for their in vitro and in vivo antifungal activities. Compound 10h showed potent activity against Rhizoctonia solani and Pyricularia oryzae, with EC50 values of 0.04 and 1.59 mg\/L, respectively. At 5 mg\/L, 10h provided 77.8% control of rice sheath blight and 88.9% control of soybean rust, outperforming fluxapyroxad and boscalid. It inhibited succinate dehydrogenase (SDH) with an IC50 value of 11.4 \u03bcM, compared with 14.5 \u03bcM for fluxapyroxad. Molecular docking and molecular dynamics simulations suggested that 10h may bind to SDH in a manner similar to that of fluxapyroxad. Compound 10h also showed lower acute toxicity to zebrafish embryos than fluxapyroxad. These results identify 10h as a promising lead for further optimization of trifluoromethylcyclopropyl-containing SDHIs.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01431","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:02:39Z","timestamp":1791543759000},"page":"32056-32066","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Novel\nPyrazole-4-Carboxamide and Aromatic\nCarboxamide Derivatives Containing a Trans-2-(Trifluoromethyl)cyclopropyl\nMoiety as Potential SDHIs"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0923-3651","authenticated-orcid":true,"given":"Jian","family":"Wang","sequence":"first","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, PR China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3008-5682","authenticated-orcid":true,"given":"Ziyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, PR China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Tian","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, PR China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-572X","authenticated-orcid":true,"given":"Hongmiao","family":"Yao","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, PR China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-1497","authenticated-orcid":true,"given":"Bu-Bing","family":"Zeng","sequence":"additional","affiliation":[{"name":"East China University of Science and Technology , , ,","place":["Shanghai, PR China, 200237"]},{"name":"East China University of Science and Technology , , ,","place":["Shanghai, PR China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2026102109072423500_cit1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s40858-023-00596-3","article-title":"New chemical\nfungicides in relation to risk for resistance development","volume":"49","author":"Ishii","year":"2024","journal-title":"Trop. 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