{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:48Z","timestamp":1785463128709,"version":"3.56.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1301002"],"award-info":[{"award-number":["2023YFD1301002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017687","name":"Guangdong Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100017687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deoxynivalenol (DON) is a prevalent mycotoxin that compromises intestinal barrier integrity, yet the mechanisms underlying DON-induced chronic inflammation remain unclear. This study investigated these mechanisms using a 28-day piglet model and porcine intestinal epithelial cells (IPEC-J2). In vivo, DON exposure caused intestinal morphological damage and inflammation, accompanied by caspase-3\/Gasdermin E (GSDME)-mediated pyroptosis. In vitro experiments confirmed that DON triggers pyroptosis via the caspase-3\/GSDME pathway. Mechanistically, activated GSDME permeabilized mitochondrial membranes, promoting cytosolic mitochondrial DNA (mtDNA) release and subsequent activation of the cGAS-STING innate immune pathway, which amplified the inflammatory response. Notably, GSDME knockdown preserved mitochondrial integrity, prevented mtDNA leakage, and blocked cGAS\u2013STING activation, thereby attenuating intestinal injury. These findings identify a sequential mechanism where the caspase-3\/GSDME axis triggers mitochondrial dysfunction and cGAS\u2013STING-mediated signaling, offering novel therapeutic targets for mycotoxin-associated enteropathy.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01535","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T09:47:48Z","timestamp":1780652868000},"page":"18339-18352","source":"Crossref","is-referenced-by-count":0,"title":["GSDME-Mediated\nPyroptosis and the mtDNA\u2013cGAS\u2013STING\nPathway Drive Deoxynivalenol-Induced Porcine Intestinal Inflammatory\nInjury"],"prefix":"10.1021","volume":"74","author":[{"given":"Fenfen","family":"Zhou","sequence":"first","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]},{"name":"Guangdong Academy of Agricultural Sciences , , ,","place":["Guangzhou, Guangdong, P. R. China, 510640"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Li","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]},{"name":"Guangdong Academy of Agricultural Sciences , , ,","place":["Guangzhou, Guangdong, P. R. China, 510640"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwen","family":"Guo","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Food and Health Guangzhou City Polytechnic , , ,","place":["Guangzhou, Guangdong, P. R. China, 511370"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqiang","family":"Mu","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]},{"name":"Guangdong Academy of Agricultural Sciences , , ,","place":["Guangzhou, Guangdong, P. R. China, 510640"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-3280","authenticated-orcid":true,"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-3779","authenticated-orcid":true,"given":"Yiqun","family":"Deng","sequence":"additional","affiliation":[{"name":"South China Agricultural University , , , ,","place":["Guangzhou, Guangdong, P. R. China, 510642"]},{"name":"Guangdong Academy of Agricultural Sciences , , ,","place":["Guangzhou, Guangdong, P. R. 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Nutr."},{"key":"2026073021175088200_cit32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.taap.2009.03.003","article-title":"The food contaminant deoxynivalenol,\ndecreases intestinal\nbarrier permeability and reduces claudin expression","volume":"237","author":"Pinton","year":"2009","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2026073021175088200_cit33","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3390\/toxins10120541","article-title":"Deoxynivalenol impairs\nporcine intestinal host defense peptide expression\nin weaned piglets and IPEC-J2 cells","volume":"10","author":"Wang","year":"2018","journal-title":"Toxins"},{"key":"2026073021175088200_cit34","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1111\/1541-4337.13203","article-title":"Global distribution, toxicity to\nhumans and animals, biodegradation, and nutritional mitigation of\ndeoxynivalenol: A review","volume":"22","author":"Tu","year":"2023","journal-title":"Compr. Rev. 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Food\nChem."},{"key":"2026073021175088200_cit41","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3390\/toxins17050241","article-title":"Cannabidiol\nmitigates deoxynivalenol-induced intestinal toxicity by regulating\ninflammation, oxidative stress, and barrier integrity","volume":"17","author":"Yang","year":"2025","journal-title":"Toxins"},{"key":"2026073021175088200_cit42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132323","article-title":"Comparing\ntwo intestinal porcine epithelial cell lines (IPECs): morphological\ndifferentiation, function and metabolism","volume":"10","author":"Nossol","year":"2015","journal-title":"PLoS\nOne"},{"key":"2026073021175088200_cit43","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.envpol.2019.05.026","article-title":"Deoxynivalenol\ninduced apoptosis and inflammation of IPEC-J2 cells by promoting ROS\nproduction","volume":"251","author":"Kang","year":"2019","journal-title":"Environ. 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