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Red mold rice (RMR), a traditional food made by fermenting rice with Monascus strains, has shown antihypertensive effects. However, research on ACE inhibitory peptides from RMR remains limited. In this study, a novel pentapeptide Val-Leu-Thr-Gly-Trp (VLTGW) was isolated from RMR and displayed potent angiotensin-converting enzyme (ACE) inhibitory activity with an IC50 value of 17.4 \u03bcM. VLTGW\u2019s 550-fold selectivity for ACE over renin indicated a potential advantage for reducing off-target effects. VLTGW retained over 90% of its activity across temperatures (20\u201380 \u00b0C) and pH conditions (2.0\u201312.0). In spontaneously hypertensive rats, VLTGW significantly lowered blood pressure, and this effect was accompanied by reduced ACE activity and angiotensin II levels and increased nitric oxide levels. Overall, these findings identify RMR as a source of an ACE-inhibitory peptide and support further evaluation of VLTGW as a functional food.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01654","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:02:00Z","timestamp":1790434920000},"page":"30722-30734","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Angiotensin\nI-Converting Enzyme Inhibitory\nPentapeptide from Red Mold Rice: Identification, Stability,\n                    <i>\n                      In V\n                      <i>i<\/i>\n                      vo\n                    <\/i>\n                    Antihypertensive Effects, and Underlying\nMechanisms"],"prefix":"10.1021","volume":"74","author":[{"given":"Yuting","family":"Liu","sequence":"first","affiliation":[{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]},{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingya","family":"Wang","sequence":"additional","affiliation":[{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]},{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Meng","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Food Nutrition and Safety , , , ,","place":["Wuhan, Hubei Province, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Han","sequence":"additional","affiliation":[{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]},{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Huang","sequence":"additional","affiliation":[{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]},{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-929X","authenticated-orcid":true,"given":"Mu","family":"Li","sequence":"additional","affiliation":[{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]},{"name":"Huazhong Agricultural University , , , ,","place":["Wuhan, Hubei Province, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"9","key":"2026100711065941900_cit1","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and\nStroke Statistics\u25002020 Update: A Report From the American Heart\nAssociation","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"issue":"4","key":"2026100711065941900_cit2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. 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