{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:03:05Z","timestamp":1793138585730,"version":"4.5.0"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21875167"],"award-info":[{"award-number":["21875167"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22075213"],"award-info":[{"award-number":["22075213"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colitis, a globally prevalent chronic gastrointestinal disorder, remains a key challenge for developing safe and effective therapies. Polysaccharide dietary fiber supplementation is a promising preventive measure. Notably, molecular weight (MW) critically determines the bioactivities of polysaccharides. Herein, we investigate the influence of Lentinus \u03b2-glucan (LBG) of distinct MWs on colitis. In our findings, LBG bound to the dectin-1 receptor on LPS-stimulated RAW264.7 macrophages and suppressed inflammatory factor secretion; orally administered LBG interacted with intestinal macrophages and alleviated colitis by reducing oxidative stress and proinflammatory factors, increasing colon length from 5.7 to 8.7 cm, restoring tissue damage, and reconstructing the intestinal mucosal barrier through upregulation of ZO-1 and Claudin-1. All these findings reversely depended on weight-average molecular weight (Mw) within 1410\u20132560 kDa, and LBG-60 with an Mw of 1410 kDa showed the optimal therapeutic effect, possibly associated with its binding to macrophages. This study provides evidence for LBG with desired MW as a dietary fiber for colitis prevention.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01897","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:02:11Z","timestamp":1785956531000},"page":"25237-25251","source":"Crossref","is-referenced-by-count":1,"title":["Lentinus \u03b2-Glucan\nBinds to Macrophages\nand Inhibits Colitis in a Molecular Weight-Dependent Manner"],"prefix":"10.1021","volume":"74","author":[{"given":"Ningyue","family":"Liu","sequence":"first","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]},{"name":"Institute of Agro-Product Processing Jiangsu Academy of Agricultural Sciences , ,","place":["Nanjing, China, 210014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqian","family":"Hu","sequence":"additional","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenni","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-5088","authenticated-orcid":true,"given":"and Xiaojuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Wuhan University , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"23","key":"2026081910145853600_cit1","doi-asserted-by":"publisher","first-page":"8184","DOI":"10.1080\/10408398.2023.2197068","article-title":"Prevention and potential\nrepair of colitis: Beneficial effects and regulatory mechanisms of\nfood-derived anti-inflammatory peptides","volume":"64","author":"Lv","year":"2024","journal-title":"Crit.\nRev. Food Sci. Nutr."},{"issue":"22","key":"2026081910145853600_cit2","doi-asserted-by":"publisher","first-page":"14341","DOI":"10.1021\/acsomega.1c01183","article-title":"Combination of UPLC\u2013Q-TOF\/MS\nand network pharmacology to reveal the mechanism of qizhen decoction\nin the treatment of colon cancer","volume":"6","author":"Kong","year":"2021","journal-title":"ACS Omega"},{"issue":"4","key":"2026081910145853600_cit3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1017\/S002966512100197X","article-title":"Inflammatory bowel disease and the gut microbiota","volume":"80","author":"Wu","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"2026081910145853600_cit4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jare.2023.01.013","article-title":"Celery soluble\ndietary fiber antagonizes flavonoids ameliorative effect on dextran-sodium-sulfate-induced\ncolitis in mice","volume":"52","author":"Wang","year":"2023","journal-title":"J. Adv. Res."},{"key":"2026081910145853600_cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1161625","article-title":"Panax quinquefolius\npolysaccharides ameliorate ulcerative\ncolitis in mice induced by dextran sulfate sodium","volume":"14","author":"Ren","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"2026081910145853600_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/polym15061414","article-title":"Effects of\npine pollen polysaccharides and sulfated polysaccharides on ulcerative\ncolitis and gut flora in mice","volume":"15","author":"Wang","year":"2023","journal-title":"Polymers"},{"key":"2026081910145853600_cit7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s43016-025-01282-0","article-title":"Dietary fibre as an\nessential nutrient","volume":"7","author":"Reynolds","year":"2026","journal-title":"Nat. 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Int."},{"issue":"18","key":"2026081910145853600_cit31","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1002\/adfm.201505155","article-title":"Silica\u2013Polymer\nHybrid with Self-Assembled PEG\nCorona Excreted Rapidly via a Hepatobiliary Route","volume":"26","author":"Zhao","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"2026081910145853600_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.105990","article-title":"Polysaccharide from\nfermented mycelium of Inonotus obliquus attenuates the ulcerative\ncolitis and adjusts the gut microbiota in mice","volume":"177","author":"Zhang","year":"2023","journal-title":"Microb. Pathog."},{"key":"2026081910145853600_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124419","article-title":"Ameliorating role of\nTetrastigma hemsleyanum polysaccharides\nin antibiotic-induced intestinal mucosal barrier dysfunction in mice\nbased on microbiome and metabolome analyses","volume":"241","author":"Zhou","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"2026081910145853600_cit34","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1039\/D3FO03412G","article-title":"A critical review on intestinal mucosal\nbarrier protection effects of dietary polysaccharides","volume":"15","author":"Yan","year":"2024","journal-title":"Food Funct."},{"issue":"3","key":"2026081910145853600_cit35","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1021\/acs.jafc.1c05966","article-title":"Protective effects of natural polysaccharides\non intestinal barrier injury: A review","volume":"70","author":"Huo","year":"2022","journal-title":"J. Agric.\nFood Chem."},{"key":"2026081910145853600_cit36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.carbpol.2018.11.087","article-title":"Inhibition\nof dextran\nsodium sulfate-induced colitis in mice by baker\u2019s yeast polysaccharides","volume":"207","author":"Sun","year":"2019","journal-title":"Carbohydr. 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Pharmacol."},{"issue":"3","key":"2026081910145853600_cit41","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i3.353","article-title":"Overview of\ncytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory\nbowel diseases","volume":"7","author":"Soufli","year":"2016","journal-title":"World J. Gastrointest. Pharmacol.\nTher."},{"issue":"14","key":"2026081910145853600_cit42","doi-asserted-by":"publisher","first-page":"14053","DOI":"10.1021\/acsnano.3c04344","article-title":"Translational selenium nanoparticles to attenuate allergic dermatitis\nthrough Nrf2-Keap1-driven activation of selenoproteins","volume":"17","author":"Xie","year":"2023","journal-title":"ACS Nano"},{"key":"2026081910145853600_cit43","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3859856","article-title":"Cynanchum\nwilfordii polysaccharides suppress dextran sulfate sodium-induced\nacute colitis in mice and the production of inflammatory mediators\nfrom macrophages","volume":"2017","author":"Cho","year":"2017","journal-title":"Mediators Inflammation"},{"key":"2026081910145853600_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116548","article-title":"Exploring\nthe mechanism of enterotoxicity\nmediated by the microbiome-butyrate-PPAR axis in podophyllotoxin through\nthe toxicological evidence chain (TEC) concept","volume":"280","author":"Duan","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"2026081910145853600_cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1397735","article-title":"Non-targeted metabolomics and pseudo-targeted\nlipidomics\ncombined with gut microbes reveal the protective effects of Causonis\njaponica (Thunb.) Raf. in ulcerative colitis mice","volume":"14","author":"Huang","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"2026081910145853600_cit46","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1089\/jmf.2019.4607","article-title":"Inhibition\nof dextran sodium sulfate-induced experimental colitis in mice by\nAngelica Sinensis polysaccharide","volume":"23","author":"Cheng","year":"2020","journal-title":"J. Med. 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Macromol."},{"key":"2026081910145853600_cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119110","article-title":"Advances in oral absorption of polysaccharides:\nMechanism, affecting factors, and improvement strategies","volume":"282","author":"Zheng","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"2026081910145853600_cit52","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-2-25","article-title":"The effects of\n\u03b2-glucan on\nhuman immune and cancer cells","volume":"2","author":"Chan","year":"2009","journal-title":"J. Hematol. Oncol."},{"key":"2026081910145853600_cit53","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jff.2017.07.061","article-title":"Immune effects\nof \u03b2-glucan\nare determined by combined effects on Dectin-1, TLR2, 4 and 5","volume":"37","author":"Kanjan","year":"2017","journal-title":"J. Funct. 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