{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:43:22Z","timestamp":1792784602915,"version":"4.5.0"},"reference-count":94,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"National Natural Science Foundation of China (NSFC)","award":["32501604"],"award-info":[{"award-number":["32501604"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extrachromosomal circular DNA (eccDNA) is an emerging class of mobile genetic elements that exist independently of linear chromosomes. Initially recognized for its role in cancer pathogenesis, eccDNA is now gaining traction in plant genomics as a potent driver of genome plasticity. In this Review, we summarize the latest research findings on eccDNA biology, focusing on its biogenesis, detection methodologies, and functional mechanisms. In addition, we propose a unifying concept of eccDNA as a dynamic \u201cadaptive genomic regulator\u201d in plants, instrumental in mediating gene dosage amplification, epigenetic reprogramming, and horizontal DNA transfer. Finally, we outline key unanswered questions and technical bottlenecks that must be addressed to translate eccDNA research into crop improvement strategies and sustainable agriculture. By framing eccDNA as an active regulatory entity rather than a passive genomic byproduct, this Review aims to catalyze research into this fascinating molecular class and its potential applications in plant biotechnology.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c01945","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:01:37Z","timestamp":1789056097000},"page":"28923-28934","source":"Crossref","is-referenced-by-count":0,"title":["Extrachromosomal Circular DNA: A Dynamic Regulator\nof Genome Plasticity and Adaptation in Plants"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2511-4896","authenticated-orcid":true,"given":"Yushuang","family":"Song","sequence":"first","affiliation":[{"name":"Qufu Normal University , , ,","place":["Qufu, China, 273165"]},{"name":"Shandong Key Laboratory of Wetland Ecology and Biodiversity Conservation in the Lower Yellow River , , ,","place":["Qufu, Shandong Province, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , ,","place":["Qufu, China, 273165"]},{"name":"Shandong Key Laboratory of Wetland Ecology and Biodiversity Conservation in the Lower Yellow River , , ,","place":["Qufu, Shandong Province, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengning","family":"Wang","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , ,","place":["Qufu, China, 273165"]},{"name":"Shandong Key Laboratory of Wetland Ecology and Biodiversity Conservation in the Lower Yellow River , , ,","place":["Qufu, Shandong Province, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026092310072051500_cit1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.tig.2017.12.010","article-title":"Discoveries of Extrachromosomal\nCircles of DNA in Normal and Tumor Cells","volume":"34","author":"Paulsen","year":"2018","journal-title":"Trends\nin Genetics."},{"key":"2026092310072051500_cit2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.jare.2025.10.005","article-title":"Beyond Chromosomes:\nExploring the Diverse Functions of Extrachromosomal\nCircular DNA","volume":"85","author":"Chen","year":"2026","journal-title":"J. Adv. Res."},{"key":"2026092310072051500_cit3","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/s41586-023-05937-5","article-title":"Extrachromosomal DNA in the Cancerous\nTransformation of Barrett\u2019s Oesophagus","volume":"616","author":"Luebeck","year":"2023","journal-title":"Nature."},{"issue":"1","key":"2026092310072051500_cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26745-3","article-title":"Focal Amplifications Are Associated with Chromothripsis\nEvents and Diverse Prognoses in Gastric Cardia Adenocarcinoma","volume":"12","author":"Zhao","year":"2021","journal-title":"Nat. Commun."},{"key":"2026092310072051500_cit5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1073\/pnas.53.2.356","article-title":"Molecular Size and\nCircularity of DNA in Cells of Mammals\nand Higher","volume":"53","author":"Hotta","year":"1965","journal-title":"Proc. Natl. Acad. Sci. U. S. 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Sci."},{"key":"2026092310072051500_cit47","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/bies.20125","article-title":"Chromosome rearrangements\nresulting from telomere dysfunction\nand their role in cancer","volume":"26","author":"Murnane","year":"2004","journal-title":"BioEssays"},{"issue":"3","key":"2026092310072051500_cit48","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41588-019-0562-0","article-title":"Pan-Cancer Analysis of Whole Genomes Identifies\nDriver Rearrangements Promoted by LINE-1 Retrotransposition","volume":"52","author":"Rodriguez-Martin","year":"2020","journal-title":"Nat. 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