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Oxadiazole, a five-membered heterocycle containing nitrogen and oxygen, has four isomers, among which 1,3,4-oxadiazole and 1,2,4-oxadiazole stand out due to favorable metabolic stability, structural modifiability, and environmental compatibility. This review systematically summarizes research advances in oxadiazole derivatives for agrochemical application published up to December 2025, covering their six major bioactivities including insecticidal, nematicidal, herbicidal, antibacterial, fungicidal, and antiviral effects, together with corresponding structure\u2013activity relationships, action mechanisms, and target interaction modes. The existing challenges and future research trends of oxadiazole pesticides are also discussed, offering theoretical support for the development of novel green agrochemicals based on oxadiazole scaffolds.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02037","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:04:37Z","timestamp":1784174677000},"page":"22409-22425","source":"Crossref","is-referenced-by-count":0,"title":["A Review: The Progress of Oxadiazole Derivatives in\nAgrochemical Application"],"prefix":"10.1021","volume":"74","author":[{"given":"Xiaoqiu","family":"Guo","sequence":"first","affiliation":[{"name":"Guizhou University , , Huaxi District, ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Guizhou University , , Huaxi District, ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Guizhou University , , Huaxi District, ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Guizhou University , , Huaxi District, ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Guizhou University , , Huaxi District, ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-6608","authenticated-orcid":true,"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Guizhou University , , Huaxi District, ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026072910061522600_cit1","unstructured":"Over 68% of farmers\nin SE Asia\u2019s biggest crop-producing countries\nclaim climate change as key challenge. 31 Aug. 2021, http:\/\/news.agropages.com\/News\/NewsDetail---40213.htm (accessed Sep. 15, 2025)."},{"key":"2026072910061522600_cit2","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2174\/1389557521666210226145837","article-title":"1,3,4-Oxadiazole\ncontaining compounds as therapeutic targets for cancer therapy","volume":"22","author":"Ahsan","year":"2022","journal-title":"Mini-Rev. 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