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Using a high-purine diet-induced HUA mouse model, this study evaluated kidney, colon, and gut microbiota damage and investigated the effects of Psidium guajava basal postbiotics (PGP). PGP reduced xanthine oxidase activity, modulated purine metabolism, and increased beneficial gut bacteria (Akkermansia muciniphila) and short-chain fatty acids (acetate, butyrate, propionate). This led to decreased blood urea nitrogen, creatinine, and renal malondialdehyde, along with reduced inflammatory factors (IL-8, LPS). Consequently, PGP alleviated HUA and mitigated HUA-induced kidney and colonic damage. This study highlights the therapeutic potential of tropical postbiotics against HUA, offering a theoretical basis for dietary supplements in chronic disease prevention.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02115","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:14:11Z","timestamp":1780560851000},"page":"17968-17979","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Alleviating\nEffect of Tropical\n                    <i>Psidium guajava<\/i>\n                    Basal\nPostbiotics on Hyperuricemia"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-4918","authenticated-orcid":true,"given":"Wenyao","family":"Ma","sequence":"first","affiliation":[{"name":"Hainan University , , , ,","place":["Haikou, Hainan, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Song","sequence":"additional","affiliation":[{"name":"Hainan University , , , ,","place":["Haikou, Hainan, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hainan University , , , ,","place":["Haikou, Hainan, China, 570228"]},{"name":"Hainan University , , , ,","place":["Haikou, Hainan, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hainan University , , , ,","place":["Haikou, Hainan, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"issue":"1","key":"2026073021155529700_cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01916-y","article-title":"Hyperuricemia and its\nrelated diseases: mechanisms and advances in\ntherapy","volume":"9","author":"Du","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"key":"2026073021155529700_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108615","article-title":"Uric acid\nin health and disease:\nFrom physiological functions to pathogenic mechanisms","volume":"256","author":"Wen","year":"2024","journal-title":"Pharmacol Ther."},{"issue":"1","key":"2026073021155529700_cit3","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14357-5","article-title":"Association between nutrient patterns\nand hyperuricemia: mediation analysis involving obesity indicators\nin the NHANES","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Public Health"},{"issue":"2","key":"2026073021155529700_cit4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41584-019-0334-3","article-title":"Asymptomatic hyperuricaemia: a silent\nactivator of\nthe innate immune system","volume":"16","author":"Joosten","year":"2020","journal-title":"Nat. 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