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This study found that its extract demonstrates a dual mechanism of action, inhibiting bacterial virulence while protecting the gastric mucosa. For multidrug-resistant strains, the minimum inhibitory concentration (MIC) range of this extract was 0.08\u20130.64 mg\/mL. At 0.32 mg\/mL, it significantly suppressed H. pylori motility and urease activity by 72% and 56%, respectively. In an infected mouse model, the extract lowered gastric pro-inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, IL-6) and promoted mucosal protection. Multiomics analysis reveals enhanced mucosal immunity and increased abundance of beneficial gastric microbiota (Ligilactobacillus and Akkermansia). As an agricultural byproduct, sea buckthorn leaf extract holds promise as a dietary supplement for managing H. pylori-associated gastropathy.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02235","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:19:12Z","timestamp":1780658352000},"page":"17980-18001","source":"Crossref","is-referenced-by-count":0,"title":["Valorization of\nSea Buckthorn (\n                    <i>Hippophae rhamnocaides<\/i>\n                    L.) Leaves: Polyphenol-Rich Extract Targeting\n                    <i>Helicobacter pylori<\/i>\n                    Virulence and Gastric Mucosal\nHomeostasis"],"prefix":"10.1021","volume":"74","author":[{"given":"Haobo","family":"Chen","sequence":"first","affiliation":[{"name":"Shenzhen Campus of Sun Yat-sen University , , ,","place":["Shenzhen, China, 518107"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuqiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Campus of Sun Yat-sen University , , ,","place":["Shenzhen, China, 518107"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Zou","sequence":"additional","affiliation":[{"name":"Shenzhen Campus of Sun Yat-sen University , , ,","place":["Shenzhen, China, 518107"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Feng","sequence":"additional","affiliation":[{"name":"Lunan Pharmaceutical Group Co., Ltd , , ,","place":["Linyi, Shandong, China, 276000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4372-6528","authenticated-orcid":true,"given":"Meicun","family":"Yao","sequence":"additional","affiliation":[{"name":"Shenzhen Campus of Sun Yat-sen University , , ,","place":["Shenzhen, China, 518107"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Peng","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine , , ,","place":["Nanchang, China, 330004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchang","family":"Chen","sequence":"additional","affiliation":[{"name":"National University of Singapore , , ,","place":["Singapore, Singapore, 117599"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"5","key":"2026073021132079600_cit1","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1093\/jaoac\/102.5.1397","article-title":"Natural Polyphenols:\nChemical Classification, Definition of Classes, Subcategories, and\nStructures","volume":"102","author":"Singla","year":"2019","journal-title":"J. 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