{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:42Z","timestamp":1792784682055,"version":"4.5.0"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302126"],"award-info":[{"award-number":["32302126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation ?Spark Action? Program of Beijing University of Agriculture","award":["BUA-HHXD2023004"],"award-info":[{"award-number":["BUA-HHXD2023004"]}],"id":[{"id":"https:\/\/ror.org\/03t9adt98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Key Project of the R&D Program of the Ningxia Hui Autonomous Region, China","award":["2023BBF01003"],"award-info":[{"award-number":["2023BBF01003"]}]},{"name":"Key Project of the R&D Program of the Ningxia Hui Autonomous Region, China","award":["2024BBF01003-03"],"award-info":[{"award-number":["2024BBF01003-03"]}]},{"name":"R&D Program of Beijing Municipal Education Commission","award":["KM202310020003"],"award-info":[{"award-number":["KM202310020003"]}],"id":[{"id":"https:\/\/ror.org\/04bpn6s66","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technology Research Program of Chongqing Municipal Education Commission","award":["KJQN202204607"],"award-info":[{"award-number":["KJQN202204607"]}],"id":[{"id":"https:\/\/ror.org\/031nm5713","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Copigmentation enhances and stabilizes wine anthocyanin color, but its behavior in multicopigment systems remains unclear. In this study, we investigated the interaction between malvidin-3-O-glucoside and gallic acid, caffeic acid, catechin, and quercetin-3-O-glucoside, focusing on additive and inhibitory effects. Multiple copigments increased the calculated fraction of red flavylium cation by up to 75%, indicating additive effects, whereas binary copigmentation showed \u221214.13% to \u221278.7% lower hyperchromic effects relative to the corresponding single-copigment. Thermodynamic analysis showed contrasting enthalpy\u2013entropy compensation patterns depending on whether a stronger copigment was introduced into a weaker system or vice versa. Quantum-chemical calculations supported possible ternary complexes and provided plausible structural explanations for inhibition. Molecular dynamics simulations further suggested competing association processes and direct copigment\u2013copigment interactions. Collectively, these results support that natural copigmentation is a dynamic multicomponent equilibrium governed by competitive and cooperative interactions, providing a framework for understanding nonlinear color responses in complex wine matrices.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02282","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:42:37Z","timestamp":1788093757000},"page":"31101-31111","source":"Crossref","is-referenced-by-count":0,"title":["Interactive Copigmentation\nin Multicopigment Systems:\nMechanistic Insights from Thermodynamics and Molecular Simulation"],"prefix":"10.1021","volume":"74","author":[{"given":"Xinyue","family":"Wei","sequence":"first","affiliation":[{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]},{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yantai University , , ,","place":["Yantai, China, 264600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"He","sequence":"additional","affiliation":[{"name":"ZKSS Technology Company , ,","place":["Shenyang, China, 110000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]},{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Ling","sequence":"additional","affiliation":[{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]},{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]},{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-7269","authenticated-orcid":true,"given":"Xinke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]},{"name":"Beijing University of Agriculture , , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026100711064426100_cit1","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.3390\/molecules13112859","article-title":"Principal component regression analysis of the relation\nbetween CIELAB color and monomeric anthocyanins in young Cabernet\nSauvignon wines","volume":"13","author":"Han","year":"2008","journal-title":"Molecules"},{"key":"2026100711064426100_cit2","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1016\/j.tet.2014.09.051","article-title":"Anthocyanins\nand derivatives are\nmore than flavylium cations","volume":"71","author":"Pina","year":"2015","journal-title":"Tetrahedron"},{"key":"2026100711064426100_cit3","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1111\/1541-4337.13010","article-title":"Red wine coloration:\nA review of pigmented molecules,\nreactions, and applications","volume":"21","author":"Zhang","year":"2022","journal-title":"Compr. 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