{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:02:08Z","timestamp":1785942128868,"version":"3.56.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100015601","name":"Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011231","name":"State Key Laboratory of Food Science and Resources","doi-asserted-by":"publisher","award":["SKLF-ZZB-202510"],"award-info":[{"award-number":["SKLF-ZZB-202510"]}],"id":[{"id":"10.13039\/501100011231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atopic dermatitis (AD) is a prevalent early childhood inflammatory skin disease frequently linked to gut dysbiosis. While Bifidobacterium longum subsp. infantis is a pioneer infant gut colonizer driving immune maturation, its role in AD prevention remains unclear. Here, we investigated early life intervention with B. longum subsp. infantis CCFM1269 using a 2,4-dinitrofluorobenzene (DNFB)-induced murine AD model. Oral administration of CCFM1269 significantly ameliorated AD symptoms, reducing skin\/ear thickness, dermatitis scores, and serum IgE. Mechanistically, CCFM1269 modulated the systemic Th1\/Th2 balance by downregulating TSLP, IL-4, and IL-13, while upregulating IFN-\u03b3. Notably, CCFM1269 produced indole-3-lactic acid (ILA). Via the gut\u2013skin axis, ILA activated the aryl hydrocarbon receptor (AHR) and its target CYP1A1 in skin tissues, strengthening the epidermal barrier. Additionally, AD mitigation was associated with gut microbiota reshaping. Ultimately, CCFM1269 alleviates AD primarily through the ILA- AHR signaling pathway, highlighting its potential as a functional food ingredient for early life AD prevention.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02316","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:02:56Z","timestamp":1784656976000},"page":"23495-23508","source":"Crossref","is-referenced-by-count":0,"title":["Early-Life Intervention\nwith\n                    <i>Bifidobacterium longum<\/i>\n                    subsp.\n                    <i>infantis<\/i>\n                    CCFM1269 Alleviates Atopic Dermatitis in Mice via the Indole-3-Lactic\nAcid-AHR Signaling Pathway"],"prefix":"10.1021","volume":"74","author":[{"given":"Zheng","family":"Huang","sequence":"first","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Stanton","sequence":"additional","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"University College Cork , , ,","place":["Cork, Ireland, T12 K8AF"]},{"name":"Teagasc Food Research Centre, Moorepark , ,","place":["Fermoy, Co. Cork, Ireland, P61 C996"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Paul","family":"Ross","sequence":"additional","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"University College Cork , , ,","place":["Cork, Ireland, T12 K8AF"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-4710","authenticated-orcid":true,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-3718","authenticated-orcid":true,"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]},{"name":"Jiangnan University , , ,","place":["Wuxi, China, 214122"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"12","key":"2026080510103497600_cit1","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic Dermatitis","volume":"384","author":"Sta\u0308nder","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"2026080510103497600_cit2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jaci.2018.11.006","article-title":"The atopic march\nand atopic multimorbidity: Many trajectories, many pathways","volume":"143","author":"Paller","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"2026080510103497600_cit3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.det.2017.02.002","article-title":"Public\nHealth Burden and Epidemiology of Atopic Dermatitis","volume":"35","author":"Silverberg","year":"2017","journal-title":"Dermatol. Clin."},{"issue":"8","key":"2026080510103497600_cit4","doi-asserted-by":"publisher","first-page":"4130","DOI":"10.3390\/ijms22084130","article-title":"Molecular Mechanisms\nof Atopic Dermatitis Pathogenesis","volume":"22","author":"Sroka-Tomaszewska","year":"2021","journal-title":"Int. J. Mol.\nSci."},{"issue":"10247","key":"2026080510103497600_cit5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"2026080510103497600_cit6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-319-64804-0_3","article-title":"Atopic Dermatitis:\nPathophysiology","volume-title":"Management of Atopic Dermatitis:\nMethods and Challenges","author":"Boothe","year":"2017"},{"issue":"8","key":"2026080510103497600_cit7","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.3390\/ijms21082867","article-title":"Skin Barrier Abnormalities and Immune\nDysfunction in\nAtopic Dermatitis","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026080510103497600_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.270","article-title":"Gut\u2013X\naxis","volume":"4","author":"Lin","year":"2025","journal-title":"iMeta"},{"issue":"21","key":"2026080510103497600_cit9","doi-asserted-by":"publisher","first-page":"13071","DOI":"10.3390\/ijms232113071","article-title":"Skin Barrier Function and the Microbiome","volume":"23","author":"Lee","year":"2022","journal-title":"Int.\nJ. Mol. Sci."},{"issue":"2","key":"2026080510103497600_cit10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3390\/microorganisms9020353","article-title":"Gut\u2013Skin Axis: Current Knowledge\nof the Interrelationship between Microbial Dysbiosis and Skin Conditions","volume":"9","author":"De Pessemier","year":"2021","journal-title":"Microorganisms"},{"issue":"10","key":"2026080510103497600_cit11","doi-asserted-by":"publisher","first-page":"827","DOI":"10.2174\/1389201019666181008113149","article-title":"A Review of Probiotic\nSupplementation and Feasibility of Topical\nApplication for the Treatment of Pediatric Atopic Dermatitis","volume":"19","author":"Marcinkowska","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"12","key":"2026080510103497600_cit12","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.3390\/medicina59122080","article-title":"Probiotics and Prebiotics\nOrally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis:\nAn Italian Real-Life, Multicenter, Retrospective, Observational Study","volume":"59","author":"Colombo","year":"2023","journal-title":"Med. Litu."},{"issue":"1","key":"2026080510103497600_cit13","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1186\/s12967-025-06769-9","article-title":"Bifidobacterium animalis subsp. Lactis BX-BC08\nmodulates gut microbiota and secretes alpha-Ketoglutaric\nacid to alleviate MC903-induced atopic dermatitis","volume":"23","author":"Zhao","year":"2025","journal-title":"J. Transl. Med."},{"issue":"4","key":"2026080510103497600_cit14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1365-2222.2011.03890.x","article-title":"No\ndetectable beneficial systemic immunomodulatory effects of a specific\nsynbiotic mixture in infants with atopic dermatitis","volume":"42","author":"van der Aa","year":"2012","journal-title":"Clin. Exp. Allergy"},{"issue":"5","key":"2026080510103497600_cit15","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s00394-019-02061-x","article-title":"Probiotics\nmodulate the gut microbiota composition and immune responses\nin patients with atopic dermatitis: a pilot study","volume":"59","author":"Fang","year":"2020","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"2026080510103497600_cit16","doi-asserted-by":"publisher","first-page":"2044723","DOI":"10.1080\/19490976.2022.2044723","article-title":"Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis\nvia the gut-skin axis","volume":"14","author":"Fang","year":"2022","journal-title":"Gut Microbes"},{"key":"2026080510103497600_cit17","doi-asserted-by":"publisher","first-page":"106392","DOI":"10.1016\/j.fbio.2025.106392","article-title":"Bifidobacterium longum subsp. Infantis modulates intestinal\nimmunity in growing mice in a strain-specific manner","volume":"68","author":"Zhang","year":"2025","journal-title":"Food Biosci."},{"issue":"1","key":"2026080510103497600_cit18","doi-asserted-by":"publisher","first-page":"2474256","DOI":"10.1080\/19490976.2025.2474256","article-title":"Extracellular\nvesicles of Limosilactobacillus fermentum SLAM216\nameliorate skin symptoms of atopic dermatitis by regulating gut microbiome\non serotonin metabolism","volume":"17","author":"Choi","year":"2025","journal-title":"Gut Microbes"},{"issue":"1","key":"2026080510103497600_cit19","doi-asserted-by":"publisher","first-page":"2290344","DOI":"10.1080\/19490976.2023.2290344","article-title":"Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269\nregulates bone formation by the GH\/IGF axis through PI3K\/AKT pathway","volume":"16","author":"Ding","year":"2024","journal-title":"Gut Microbes"},{"key":"2026080510103497600_cit20","doi-asserted-by":"publisher","first-page":"416739","DOI":"10.1155\/2012\/416739","article-title":"Changes\nin the Th1:Th2 cytokine bias\nin pregnancy and the effects of the anti-inflammatory cyclopentenone\nprostaglandin 15-deoxy-\u0394(12,14)-prostaglandin J2","volume":"2012","author":"Sykes","year":"2012","journal-title":"Mediators Inflammation"},{"issue":"12","key":"2026080510103497600_cit21","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1111\/j.1365-2222.2011.03827.x","article-title":"A Th1\/Th2-associated\nchemokine imbalance during infancy\nin children developing eczema, wheeze and sensitization","volume":"41","author":"Abrahamsson","year":"2011","journal-title":"Clin. Exp. Allergy"},{"issue":"1","key":"2026080510103497600_cit22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1046\/j.1365-2133.2003.04934.x","article-title":"Clinical dose\nand adverse effects\nof topical steroids in daily management of atopic dermatitis","volume":"148","author":"Furue","year":"2003","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"2026080510103497600_cit23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/bjd.15928","article-title":"Use\nof systemic corticosteroids for atopic\ndermatitis: International Eczema Council consensus statement","volume":"178","author":"Drucker","year":"2018","journal-title":"Br. J. Dermatol."},{"issue":"14","key":"2026080510103497600_cit24","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.3390\/nu15143123","article-title":"The Role of Probiotics\nin Skin Health and Related Gut-Skin Axis: A Review","volume":"15","author":"Gao","year":"2023","journal-title":"Nutrients"},{"issue":"6","key":"2026080510103497600_cit25","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.5851\/kosfa.2024.e100","article-title":"Interconnection\nof the Gut-Skin Axis\nin NC\/Nga Mouse with Atopic Dermatitis: Effects of the Three Types\nof Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics,\nand Cytosine-Phosphate- Guanine Oligodeoxynucleotide) on T Cell Differentiation\nand Gut Microbiota","volume":"44","author":"Kim","year":"2024","journal-title":"Food Sci. Anim. Resour."},{"issue":"14","key":"2026080510103497600_cit26","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.3390\/foods13142190","article-title":"Daily\nSupplementation with Bifidobacterium longum KACC91563 Alleviates Allergic Contact Dermatitis in\nan Animal Model","volume":"13","author":"Hoa","year":"2024","journal-title":"Foods"},{"key":"2026080510103497600_cit27","doi-asserted-by":"publisher","first-page":"103426","DOI":"10.1016\/j.jff.2019.103426","article-title":"Strain-specific ameliorating effect\nof Bifidobacterium longum on atopic dermatitis in\nmice","volume":"60","author":"Fang","year":"2019","journal-title":"J. Funct. Foods"},{"issue":"12","key":"2026080510103497600_cit28","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1038\/jid.2015.318","article-title":"TSLP Directly\nInteracts with Skin-Homing Th2 Cells Highly Expressing its Receptor\nto Enhance IL-4 Production in Atopic Dermatitis","volume":"135","author":"Tatsuno","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"2026080510103497600_cit29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41423-025-01261-2","article-title":"Type 2 immunity in allergic diseases","volume":"22","author":"Ogulur","year":"2025","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"2026080510103497600_cit30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1046\/j.0905-6157.2003.00106.x","article-title":"Does the severity of atopic dermatitis\ncorrelate with\nserum IgE levels?","volume":"15","author":"Laske","year":"2004","journal-title":"Pediatr. Allergy Immunol."},{"issue":"3","key":"2026080510103497600_cit31","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3390\/antiox9030196","article-title":"Oxidative Stress and\nAtopic Dermatitis","volume":"9","author":"Bertino","year":"2020","journal-title":"Antioxidants"},{"key":"2026080510103497600_cit32","doi-asserted-by":"publisher","first-page":"1462491","DOI":"10.3389\/fmicb.2024.1462491","article-title":"The changes of intestinal flora and\nmetabolites in atopic dermatitis mice","volume":"15","author":"Wang","year":"2024","journal-title":"Front.\nMicrobiol."},{"issue":"2","key":"2026080510103497600_cit33","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cyto.2015.05.016","article-title":"Tannic acid modulates\nNF\u03baB signaling pathway and skin inflammation in NC\/Nga mice\nthrough PPAR\u03b3 expression","volume":"76","author":"Karuppagounder","year":"2015","journal-title":"Cytokine"},{"key":"2026080510103497600_cit34","doi-asserted-by":"publisher","first-page":"6908","DOI":"10.3390\/ijms25136908","article-title":"Effect\nof Isoscopoletin on Cytokine\nExpression in HaCaT Keratinocytes and RBL-2H3 Basophils: Preliminary\nStudy","volume":"25","author":"Seo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"2026080510103497600_cit35","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1016\/j.jid.2017.05.004","article-title":"Tapinarof Is a Natural AhR Agonist that Resolves Skin\nInflammation in Mice and Humans","volume":"137","author":"Smith","year":"2017","journal-title":"J. Invest.\nDermatol."},{"issue":"2","key":"2026080510103497600_cit36","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1172\/JCI65642","article-title":"Coal tar induces AHR-dependent skin barrier repair\nin atopic dermatitis","volume":"123","author":"van den Bogaard","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"15","key":"2026080510103497600_cit37","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.3390\/ijms21155382","article-title":"Regulation\nof Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22,\nAHR, and NRF2: Pathogenic Implications in Atopic Dermatitis","volume":"21","author":"Furue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"2026080510103497600_cit38","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/microorganisms7090340","article-title":"Production\nof Indole-3-Lactic Acid\nby Bifidobacterium Strains Isolated from Human Infants","volume":"7","author":"Sakurai","year":"2019","journal-title":"Microorganisms"},{"issue":"2","key":"2026080510103497600_cit39","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41390-019-0740-x","article-title":"Indole-3-lactic\nacid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory\nin the immature intestine","volume":"88","author":"Meng","year":"2020","journal-title":"Pediatr. Res."},{"issue":"15","key":"2026080510103497600_cit40","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1016\/j.cell.2021.05.030","article-title":"Bifidobacteria-mediated immune system imprinting early\nin life","volume":"184","author":"Henrick","year":"2021","journal-title":"Cell"},{"issue":"1","key":"2026080510103497600_cit41","doi-asserted-by":"publisher","DOI":"10.20517\/mrr.2023.64","article-title":"Bifidobacterium longum subsp. infantis regulates Th1\/Th2 balance through\nthe JAK-STAT pathway in growing mice","volume":"3","author":"Ding","year":"2024","journal-title":"Microbiome\nRes. Rep."},{"issue":"3","key":"2026080510103497600_cit42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.jid.2023.07.027","article-title":"Benvitimod\nInhibits IL-4\u2013\nand IL-13\u2013Induced Tight Junction Impairment by Activating AHR\/ARNT\nPathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes","volume":"144","author":"Wang","year":"2024","journal-title":"J. Invest. Dermatol."},{"key":"2026080510103497600_cit43","doi-asserted-by":"publisher","first-page":"4996","DOI":"10.1038\/s41598-019-41149-6","article-title":"Gut microbiota\nprofile in children\naffected by atopic dermatitis and evaluation of intestinal persistence\nof a probiotic mixture","volume":"9","author":"Reddel","year":"2019","journal-title":"Sci. Rep."},{"key":"2026080510103497600_cit44","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.eng.2023.04.010","article-title":"Bifidobacterium longum CCFM1077 Attenuates\nHyperlipidemia by Modulating the Gut Microbiota Composition and Fecal\nMetabolites: A Randomized, Double-Blind, Placebo-Controlled Clinical\nTrial","volume":"28","author":"Chu","year":"2023","journal-title":"Eng."},{"key":"2026080510103497600_cit45","doi-asserted-by":"publisher","first-page":"886196","DOI":"10.3389\/fcimb.2022.886196","article-title":"The Difference\nof Gut Microbiota and Their Correlations With Urinary Organic Acids\nBetween Autistic Children With and Without Atopic Dermatitis","volume":"12","author":"Hong","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"11","key":"2026080510103497600_cit46","doi-asserted-by":"publisher","first-page":"6271","DOI":"10.1039\/D2FO00157H","article-title":"Ameliorating\nthe efficacy of galacto-oligosaccharides on ovalumin-induced allergic\ndermatitis symptoms in Balb\/c mice by regulating Th2 immune response\nand the ecosystem of gut microbiota","volume":"13","author":"Han","year":"2022","journal-title":"Food Funct."},{"issue":"11","key":"2026080510103497600_cit47","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.3390\/foods11111551","article-title":"Protective\nEffects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of\nColitis Mice via Modulating the Ppar\u03b3\/STAT3 Pathway and Intestinal\nMicrobiota","volume":"11","author":"Guo","year":"2022","journal-title":"Foods"},{"issue":"3","key":"2026080510103497600_cit48","doi-asserted-by":"publisher","first-page":"404","DOI":"10.4168\/aair.2021.13.3.404","article-title":"Interactions Between IL-17 Variants and Streptococcus in the Gut Contribute to the Development of Atopic Dermatitis in\nInfancy","volume":"13","author":"Kang","year":"2021","journal-title":"Allergy, Asthma Immunol. Res."},{"issue":"11","key":"2026080510103497600_cit49","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1016\/j.jid.2016.05.127","article-title":"Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis\nto Trigger Cytokine Expression","volume":"136","author":"Nakatsuji","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"2026080510103497600_cit50","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1067\/mai.2003.105","article-title":"Differences\nin fecal microflora between\npatients with atopic dermatitis and healthy control subjects","volume":"111","author":"Watanabe","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026080510103497600_cit51","doi-asserted-by":"publisher","first-page":"108451","DOI":"10.1016\/j.bioorg.2025.108451","article-title":"The diphenylpyrimidine derivative as a novel HDAC6\ninhibitor alleviates atopic dermatitis through anti-inflammatory effects\nfacilitated via TLR4\/MAPK, STAT3 and NF-\u03baB pathways","volume":"160","author":"Chen","year":"2025","journal-title":"Bioorg. Chem."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c02316","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/30\/23495\/66090826\/acs.jafc.6c02316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/30\/23495\/66090826\/acs.jafc.6c02316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:24:23Z","timestamp":1785939863000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/30\/23495\/5224867\/Early-Life-Intervention-with-Bifidobacterium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":51,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,21]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c02316","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}