{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:26:07Z","timestamp":1787153167390,"version":"build-2736575974"},"reference-count":80,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300421263"],"award-info":[{"award-number":["262300421263"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Commonwealth Specialized Research Fund of Luoyang","award":["2302032A"],"award-info":[{"award-number":["2302032A"]}]},{"name":"Doctoral Scientific Research Start-up Foundation of Henan University of Science and Technology","award":["13480075"],"award-info":[{"award-number":["13480075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Succinate dehydrogenase inhibitor (SDHI) fungicides pose potential risks to nontarget aquatic organisms. Fluindapyr, a newly registered SDHI fungicide, is likely to enter aquatic environments, yet its toxicity remains largely unexplored. Here, zebrafish (Danio rerio) embryos were used to assess their developmental toxicity and underlying mechanisms. Fluindapyr exhibited high toxicity, with a 96 h LC50 of 0.36 mg\/L, and induced multiple developmental defects including edema, growth retardation, reduced locomotion, and bradycardia. Transcriptomic analysis revealed that differentially expressed genes were enriched in pathways related to cardiac muscle contraction and adrenergic signaling, indicating cardiac dysfunction as the primary target. Molecular docking further showed the strong binding of fluindapyr to the L-type calcium channel CaV1.2, suggesting a potential involvement of calcium signaling. Additionally, reduced ATP levels and the suppression of glycolysis-related genes indicated impaired energy metabolism. At higher concentrations, immune- and inflammation-related pathways were activated. These findings highlight cardiotoxicity and energy disruption as key mechanisms underlying fluindapyr-induced developmental toxicity.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02355","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:01:41Z","timestamp":1786107701000},"page":"24974-24988","source":"Crossref","is-referenced-by-count":0,"title":["Developmental Toxicity\nand Mechanistic Insights into\nthe Novel Fungicide Fluindapyr in Zebrafish Embryos"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-8651","authenticated-orcid":true,"given":"Le","family":"Qian","sequence":"first","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"He","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6211-9531","authenticated-orcid":true,"given":"Xiaobo","family":"Huang","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-6235","authenticated-orcid":true,"given":"Zhiping","family":"Che","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-5994","authenticated-orcid":true,"given":"Shengming","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , , ,","place":["Luoyang, Henan Province, China, 471023"]},{"name":"Henan Province Engineering Technology Research Center of Green Plant Protection , , ,","place":["Luoyang, Henan Province, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"3","key":"2026081910151007700_cit1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10646-024-02849-6","article-title":"Ecotoxicological impact of succinate\ndehydrogenase inhibitor (SDHI) fungicides on non-targeted organisms:\na review","volume":"34","author":"Dwivedi","year":"2025","journal-title":"Ecotoxicology"},{"key":"2026081910151007700_cit2","doi-asserted-by":"publisher","first-page":"116735","DOI":"10.1016\/j.ecoenv.2024.116735","article-title":"Study on the enantioselective\nbehaviors, activity, toxicity and mechanism of novel SDHI fungicide\nbenzovindiflupyr to reduce the environmental risks","volume":"282","author":"Di","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"2026081910151007700_cit3","doi-asserted-by":"publisher","first-page":"180385","DOI":"10.1016\/j.scitotenv.2025.180385","article-title":"Agrochemical fungicides as environmental drivers of antifungal resistance","volume":"1000","author":"Parra","year":"2025","journal-title":"Sci. Total Environ."},{"issue":"5","key":"2026081910151007700_cit4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3390\/toxins11050272","article-title":"Impact of five succinate\ndehydrogenase inhibitors on DON biosynthesis\nof Fusarium asiaticum, causing fusarium head blight\nin wheat","volume":"11","author":"Xu","year":"2019","journal-title":"Toxins"},{"key":"2026081910151007700_cit5","doi-asserted-by":"publisher","first-page":"108219","DOI":"10.1016\/j.envint.2023.108219","article-title":"SDHi fungicides: An example of mitotoxic pesticides\ntargeting the succinate dehydrogenase complex","volume":"180","author":"Duarte Hospital","year":"2023","journal-title":"Environ. Int."},{"issue":"10","key":"2026081910151007700_cit6","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5821","article-title":"Peer review of\nthe pesticide risk assessment of the active substance pydiflumetofen","volume":"17","author":"European Food Safety Authority EFSA.","year":"2019","journal-title":"EFSA J."},{"key":"2026081910151007700_cit7","doi-asserted-by":"publisher","first-page":"106665","DOI":"10.1016\/j.pestbp.2025.106665","article-title":"Comprehensive\nrisk assessment for five SDHI fungicides with AhR agonistic activity\nto aquatic ecosystems","volume":"215","author":"Shen","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"key":"2026081910151007700_cit8","doi-asserted-by":"publisher","first-page":"177538","DOI":"10.1016\/j.scitotenv.2024.177538","article-title":"A systematic workflow of data mining\nconfirms widespread ecological\nrisks of SDHIs fungicides contamination in aquatic environment","volume":"957","author":"Xu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"2026081910151007700_cit9","doi-asserted-by":"publisher","first-page":"106972","DOI":"10.1016\/j.jfca.2024.106972","article-title":"A modified\nmethod for\nthe simultaneous determination of fluindapyr and its metabolites residues\nin vegetables and fruits by SPE and UHPLCMS\/MS","volume":"137","author":"Han","year":"2025","journal-title":"J. Food Compos. Anal."},{"key":"2026081910151007700_cit10","doi-asserted-by":"publisher","first-page":"133571","DOI":"10.1016\/j.foodchem.2022.133571","article-title":"Separation and determination of fluindapyr\nenantiomers in cucumber and tomato and by supercritical fluid chromatography\ntandem mass spectrometry","volume":"395","author":"Guo","year":"2022","journal-title":"Food Chem."},{"issue":"1","key":"2026081910151007700_cit11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1094\/PDIS-10-19-2125-RE","article-title":"Baseline\nand Temporal Changes in\nSensitivity of Zymoseptoria tritici Isolates to Benzovindiflupyr in\nOregon, U.S.A., and Cross-Sensitivity to Other SDHI Fungicides","volume":"105","author":"Hagerty","year":"2021","journal-title":"Plant Dis."},{"issue":"3","key":"2026081910151007700_cit12","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1021\/acs.jafc.2c07924","article-title":"Enantioselective degradation and\nbioactivity mechanism\nof a new chiral fungicide fluindapyr in paddy ecosystems","volume":"71","author":"Tong","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"2026081910151007700_cit13","doi-asserted-by":"publisher","first-page":"144112","DOI":"10.1016\/j.molstruc.2025.144112","article-title":"Novel pyrazole-4-carboxamides\ncontaining a piperazine moiety: Synthesis, crystal structure, antifungal\nactivity, molecular docking, DFT and ESP calculations","volume":"1350","author":"Luo","year":"2026","journal-title":"J. Mol. Struct."},{"key":"2026081910151007700_cit14","doi-asserted-by":"publisher","first-page":"109923","DOI":"10.1016\/j.envres.2020.109923","article-title":"Bixafen exposure induces\ndevelopmental toxicity in zebrafish (Danio rerio)\nembryos","volume":"189","author":"Li","year":"2020","journal-title":"Environ. Res."},{"key":"2026081910151007700_cit15","doi-asserted-by":"publisher","first-page":"165697","DOI":"10.1016\/j.scitotenv.2023.165697","article-title":"Evaluation of the toxic\neffects of fluindapyr, a novel SDHI fungicide,\nto the earthworms Eisenia fetida","volume":"899","author":"Ji","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"22","key":"2026081910151007700_cit16","doi-asserted-by":"publisher","first-page":"14275","DOI":"10.1021\/acs.est.0c02871","article-title":"Exposure to\nboscalid induces reproductive toxicity of zebrafish by\ngender-specific alterations in steroidogenesis","volume":"54","author":"Qian","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"2026081910151007700_cit17","doi-asserted-by":"crossref","DOI":"10.1787\/9789264076228-en","article-title":"Test No. 230:21- day fish assay: A short-term screening\nfor oestrogenic and androgenic activity, and aromatase inhibition","volume-title":"OECD Guidelines for the Testing of Chemicals","author":"OECD.","year":"2009"},{"key":"2026081910151007700_cit18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.envpol.2012.12.029","article-title":"Evaluation\nof acute\nand developmental effects of difenoconazole via multiple stage zebrafish\nassays","volume":"175","author":"Mu","year":"2013","journal-title":"Environ. Pollut."},{"key":"2026081910151007700_cit19","article-title":"Test No. 236: Fish embryo acute toxicity\n(FET) test","author":"OECD.","year":"2013","journal-title":"OECD Guidelines for the Testing\nof Chemicals"},{"issue":"6","key":"2026081910151007700_cit20","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/nar\/gkp1137","article-title":"The Sanger\nFASTQ file format for sequences with quality scores, and the Solexa\/Illumina\nFASTQ variants","volume":"38","author":"Cock","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"2026081910151007700_cit21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT:\na fast spliced aligner with\nlow memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"12","key":"2026081910151007700_cit22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated\nestimation of fold change\nand dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"5","key":"2026081910151007700_cit23","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler:\nan R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS: A Journal of Integrative Biology"},{"issue":"1","key":"2026081910151007700_cit24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes\nand genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2026081910151007700_cit25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool\nfor the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2026081910151007700_cit26","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.scitotenv.2018.04.012","article-title":"Mechanisms\nof developmental toxicity in zebrafish embryos (Danio rerio) induced by boscalid","volume":"634","author":"Qian","year":"2018","journal-title":"Sci. Total Environ."},{"key":"2026081910151007700_cit27","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.chemosphere.2018.09.117","article-title":"Effects of\npenthiopyrad on the development and behaviour of zebrafish\nin early-life stages","volume":"214","author":"Qian","year":"2019","journal-title":"Chemosphere"},{"issue":"1","key":"2026081910151007700_cit28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00128-016-1833-4","article-title":"Toxic effects\nof bromothalonil and flutolanil on multiple developmental stages in\nzebrafish","volume":"97","author":"Yang","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"2026081910151007700_cit29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jhazmat.2015.12.055","article-title":"Toxic effects\nof Thifluzamide on zebrafish (Danio rerio)","volume":"307","author":"Yang","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"2026081910151007700_cit30","article-title":"Effect of pesticides and metals\non zebrafish embryo development and larval locomotor activity","author":"Ahmad","year":"2020","journal-title":"bioRxiv"},{"issue":"23","key":"2026081910151007700_cit31","doi-asserted-by":"publisher","first-page":"5934","DOI":"10.1111\/j.1742-4658.2008.06722.x","article-title":"Purification and characterization\nof zebrafish hatching enzyme - an evolutionary aspect of the mechanism\nof egg envelope digestion","volume":"275","author":"Sano","year":"2008","journal-title":"FEBS J."},{"key":"2026081910151007700_cit32","doi-asserted-by":"publisher","first-page":"144519","DOI":"10.1016\/j.scitotenv.2020.144519","article-title":"Toxic effects and potential\nmechanisms of Fluxapyroxad to zebrafish (Danio rerio) embryos","volume":"769","author":"Lin","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"6","key":"2026081910151007700_cit33","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/bdrb.20276","article-title":"A different\napproach to validating\nscreening assays for developmental toxicity","volume":"89","author":"Daston","year":"2010","journal-title":"Birth Defects Research Part B: Developmental and Reproductive Toxicology"},{"key":"2026081910151007700_cit34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1289\/ehp.877177","article-title":"Pollutants as developmental\ntoxicants in aquatic organisms","volume":"71","author":"Weis","year":"1987","journal-title":"Environ. Health\nPerspect."},{"issue":"1","key":"2026081910151007700_cit35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.tiv.2012.07.010","article-title":"Assessment of developmental\ndelay in the zebrafish\nembryo teratogenicity assay","volume":"27","author":"Teixido\u0301","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"2026081910151007700_cit36","article-title":"KLHL41 orchestrates sarcomere\nassembly and size to\ndrive skeletal muscle hypertrophy in vivo","author":"Han","year":"2025","journal-title":"bioRxiv"},{"issue":"1\u20132","key":"2026081910151007700_cit37","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000368411","article-title":"Wnt5a is necessary for normal kidney\ndevelopment in zebrafish and mice","volume":"128","author":"Huang","year":"2014","journal-title":"Nephron Experimental\nNephrology"},{"issue":"1","key":"2026081910151007700_cit38","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.1038\/s41467-021-24169-7","article-title":"Analysis\nof gene\nnetwork bifurcation during optic cup morphogenesis in zebrafish","volume":"12","author":"Buono","year":"2021","journal-title":"Nat. Commun."},{"issue":"24","key":"2026081910151007700_cit39","doi-asserted-by":"publisher","first-page":"dev201786","DOI":"10.1242\/dev.201786","article-title":"Endothelin\nsignaling in development","volume":"150","author":"Kanai","year":"2023","journal-title":"Development"},{"issue":"7","key":"2026081910151007700_cit40","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.modgep.2007.06.003","article-title":"Mrf4 (myf6)\nis dynamically expressed in differentiated zebrafish skeletal muscle","volume":"7","author":"Hinits","year":"2007","journal-title":"Gene Expression Patterns"},{"issue":"6","key":"2026081910151007700_cit41","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12038-019-9948-5","article-title":"Sp7\/osterix\npositively regulates dlx2b and bglap to affect tooth development and\nbone mineralization in zebrafish larvae","volume":"44","author":"Chen","year":"2019","journal-title":"J.\nBiosci."},{"issue":"5","key":"2026081910151007700_cit42","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1161\/ATVBAHA.123.318287","article-title":"Zebrafish ApoB-containing\nlipoprotein metabolism: A\ncloser look","volume":"44","author":"Moll","year":"2024","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2026081910151007700_cit43","doi-asserted-by":"publisher","first-page":"163783","DOI":"10.1016\/j.scitotenv.2023.163783","article-title":"Toxic effects of triphenyltin\non the development of zebrafish (Danio rerio) embryos","volume":"885","author":"Qiao","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"6","key":"2026081910151007700_cit44","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1093\/nar\/gkae095","article-title":"The chromatin accessibility\ndynamics\nduring cell fate specifications in zebrafish early embryogenesis","volume":"52","author":"Xu","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"2026081910151007700_cit45","doi-asserted-by":"publisher","first-page":"715","DOI":"10.7150\/ijbs.9126","article-title":"Type-IV antifreeze proteins are essential for epiboly and convergence\nin gastrulation of zebrafish embryos","volume":"10","author":"Xiao","year":"2014","journal-title":"Int. J.\nBiol. Sci."},{"key":"2026081910151007700_cit46","doi-asserted-by":"publisher","first-page":"116976","DOI":"10.1016\/j.ecoenv.2024.116976","article-title":"Acute indomethacin\nexposure impairs cardiac development by affecting cardiac muscle contraction\nand inducing myocardial apoptosis in zebrafish (Danio rerio)","volume":"283","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"46","key":"2026081910151007700_cit47","doi-asserted-by":"publisher","first-page":"29296","DOI":"10.1021\/acs.jafc.5c09133","article-title":"From molecular structure to food safety: mechanistic analysis of\nstrobilurin-induced cardiotoxicity in zebrafish and LC50-based QSAR modeling for toxicity prediction","volume":"73","author":"Yan","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026081910151007700_cit48","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.envpol.2017.11.095","article-title":"Exposure to\nacrylamide induces cardiac developmental toxicity in zebrafish during\ncardiogenesis","volume":"234","author":"Huang","year":"2018","journal-title":"Environ. Pollut."},{"issue":"2","key":"2026081910151007700_cit49","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1093\/toxsci\/kfi073","article-title":"Heart malformation\nis an early response to TCDD in embryonic zebrafish","volume":"84","author":"Antkiewicz","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"27","key":"2026081910151007700_cit50","doi-asserted-by":"publisher","first-page":"36303","DOI":"10.1007\/s11356-021-13238-5","article-title":"Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos","volume":"28","author":"Yuan","year":"2021","journal-title":"Environ. Sci.\nPollut. Res."},{"issue":"4","key":"2026081910151007700_cit51","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1242\/jcs.071274","article-title":"Troponin T is essential\nfor sarcomere assembly in zebrafish skeletal muscle","volume":"124","author":"Ferrante","year":"2011","journal-title":"J. Cell Sci."},{"issue":"25","key":"2026081910151007700_cit52","doi-asserted-by":"publisher","first-page":"6165","DOI":"10.1242\/dev.00844","article-title":"Na,K-ATPase is essential for embryonic\nheart development in the zebrafish","volume":"130","author":"Shu","year":"2003","journal-title":"Development"},{"key":"2026081910151007700_cit53","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.pbiomolbio.2018.06.007","article-title":"Identification\nof\nthe actc1c cardiac actin gene in zebrafish","volume":"138","author":"Ojehomon","year":"2018","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"14","key":"2026081910151007700_cit54","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1016\/j.devcel.2024.04.012","article-title":"Cox7a1 controls skeletal muscle physiology and heart\nregeneration through complex IV dimerization","volume":"59","author":"Garci\u0301a-Poyatos","year":"2024","journal-title":"Dev. 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