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Although current clinical management with proton pump inhibitors and Helicobacter pylori eradication is highly effective, there remains a need for early intervention strategies that directly promote gastric mucosal repair and prevent ulcer recurrence. This study demonstrates that dihydromyricetin (DHM), a natural flavonoid compound found in abundance in vine tea, alleviates gastric mucosal injury and promotes repair in rats via inhibiting ferroptosis. Mechanistically, DHM was proved to suppress oxidative stress and ferroptosis by activating the SLC7A11\/GPX4 signaling pathway. Furthermore, DHM directly stabilizes SLC7A11 and promotes its membrane localization by disrupting binding with its E3 ubiquitin ligase SYVN1, thereby inhibiting SYVN1-mediated K48-linked ubiquitination at K30, K37, and K483. Moreover, DHM exerts protective effects in human-derived gastric organoid models, promoting growth and morphological repair. Collectively, DHM promotes gastric repair by suppressing ferroptosis via blocking SYVN1-dependent SLC7A11degradation.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c02741","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:32:08Z","timestamp":1780903928000},"page":"18002-18018","source":"Crossref","is-referenced-by-count":1,"title":["Dihydromyricetin\nBlocks SYVN1-Mediated Degradation\nof SLC7A11 to Suppress Ferroptosis and Promote Gastric Repair"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2822-6912","authenticated-orcid":true,"given":"Yuanhao","family":"Zhang","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610072"]},{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610075"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610072"]},{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610075"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichao","family":"Hu","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610072"]},{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610075"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital , , ,","place":["Beijing, China, 100039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Health Preservation and Preventive Treatment of Disease, Chengdu University of Traditional Chinese Medicine , ,","place":["Chengdu, China, 611137"]},{"name":"School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 611137"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610072"]},{"name":"Chengdu University of Traditional Chinese Medicine , , ,","place":["Chengdu, China, 610075"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"10447","key":"2026073021151639700_cit1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S0140-6736(24)00155-7","article-title":"Peptic ulcer disease","volume":"404","author":"Almadi","year":"2024","journal-title":"Lancet"},{"issue":"4","key":"2026073021151639700_cit2","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/jamasurg.2024.6724","article-title":"Management of Perforated\nPeptic Ulcer:\nA Review","volume":"160","author":"Arshad","year":"2025","journal-title":"JAMA Surg."},{"issue":"21","key":"2026073021151639700_cit3","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1001\/jama.2024.19094","article-title":"Peptic Ulcer\nDisease: A Review","volume":"332","author":"Vakil","year":"2024","journal-title":"Jama"},{"issue":"5","key":"2026073021151639700_cit4","doi-asserted-by":"publisher","first-page":"Cd014585","DOI":"10.1002\/14651858.CD014585.pub2","article-title":"Proton pump inhibitors for the prevention\nof non-steroidal\nanti-inflammatory drug-induced ulcers and dyspepsia","volume":"2025","author":"Garegnani","year":"2025","journal-title":"Cochrane Database Syst. 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