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This study compared emulsified mulberry extract (EME) and aqueous mulberry extract (AME) on anxiety- and depression-like behaviors in male C57BL\/6J mice exposed to chronic unpredictable mild stress (CUMS), and explored the underlying mechanisms of EME. EME alleviated anxiety- and depression-like behaviors more effectively than AME, with superior colloidal stability and dispersion. Metabolomic profiling revealed higher relative abundances of carbohydrates, eicosanoids, and flavonoids in EME. EME remodeled the gut microbiota\u2013short-chain fatty acid (SCFA) axis, enhanced colonic barrier integrity, reduced serum lipopolysaccharide and proinflammatory cytokines, decreased stress hormone levels, elevated 5-hydroxytryptamine, and suppressed hippocampal glial activation while preserving neuronal integrity. Correlation analyses linked gut microbiota, SCFAs, hypothalamic-pituitary-adrenal axis activity, and behavioral phenotypes. These findings indicate that emulsification enhances the bioactivity of whole-component mulberry extracts, supporting their potential as natural food-based interventions for emotional disorders.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c03546","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:50:10Z","timestamp":1788263410000},"page":"27497-27511","source":"Crossref","is-referenced-by-count":0,"title":["Emulsified Mulberry Extract Alleviates CUMS-Induced\nAnxiety- and Depressive-Like Behaviors in Mice in Association with\nGut Microbiota and Short-Chain Fatty Acids"],"prefix":"10.1021","volume":"74","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100191"]},{"name":"Northwest A&F University , , , ,","place":["Yangling, Shaanxi, China, 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518000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebo","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , , ,","place":["Yangling, Shaanxi, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Lu","sequence":"additional","affiliation":[{"name":"Peking University , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-763X","authenticated-orcid":true,"given":"Tian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Northwest A&F University , , , ,","place":["Yangling, Shaanxi, China, 712100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"1","key":"2026090917071436600_cit1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/glia.24464","article-title":"Chronic psychosocial 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