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This study evaluated cyanidin-3-glucoside-4-vinylphenol (C3G_VP), a novel class of anthocyanin derivative synthesized via Lactiplantibacillus plantarum fermentation, and its chemical structure was identified by NMR spectroscopy. In Cd-exposed mice, C3G_VP significantly ameliorated dyslipidemia by reducing hepatic TC (\u221285.5%), TG (\u221280.6%), and LDL-C (\u221235.8%) levels while increasing HDL-C (+50.7%) levels and decreasing hepatic lipid droplet accumulation. Mechanistically, C3G_VP administration may activate the FXR\u2013FGF axis and regulate hepatic FXR and Cyp7a1 protein expression, leading to reduced hepatic bile acid (BA) accumulation and enhanced fecal BA excretion. Furthermore, C3G_VP administration inhibited proinflammatory cytokine mRNA expression (hepatic TNF and IL6, and colonic TNF and IL1\u03b2). Importantly, C3G_VP administration increased beneficial bacteria (Adlercreutzia, Lactobacillus, and Bifidobacterium), which were positively associated with short-chain fatty acid (SCFA) production. Overall, C3G_VP shows potential as a stable anthocyanin pigment against Cd-induced lipid metabolic disorders.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c03768","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:38:49Z","timestamp":1785854329000},"page":"24344-24360","source":"Crossref","is-referenced-by-count":1,"title":["Cyanidin-3-glucoside-4-vinylphenol\nMitigates Cadmium-Induced\nHepatic and Colonic Injury via the Modulation of Lipid Metabolism\nand Gut Microbiota in Mice"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7412-4749","authenticated-orcid":true,"given":"Qing","family":"Zhang","sequence":"first","affiliation":[{"name":"Jinan University , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-8775","authenticated-orcid":true,"given":"Dawei","family":"Sun","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Fan","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4043-5232","authenticated-orcid":true,"given":"Jianxia","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong University of Technology , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-2970","authenticated-orcid":true,"given":"Weibin","family":"Bai","sequence":"additional","affiliation":[{"name":"Jinan University , , ,","place":["Guangdong, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026081208083645500_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128795","article-title":"Deep learning\napproach identified a gene signature predictive of the severity of\nrenal damage caused by chronic cadmium accumulation","volume":"433","author":"Feng","year":"2022","journal-title":"J. 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Agric. Food Chem."},{"issue":"30","key":"2026081208083645500_cit30","doi-asserted-by":"publisher","first-page":"18657","DOI":"10.1021\/acs.jafc.5c04440","article-title":"Lactiplantibacillus plantarum FEED8-Accelerated\nBiotransformation of Hydroxycinnamic Acids and Anthocyanins into Hydroxyphenyl-Type\nPyranoanthocyanins and Characterization of Their Stability and Antioxidant\nCapacity","volume":"73","author":"Zhang","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"2026081208083645500_cit31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26041521","article-title":"Vitisin A\noutperforms Cyanidin-3-O-Glucoside in triglyceride reduction by modulating\nhepatic lipogenesis and fatty acid \u03b2-Oxidation","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. 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