{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:06:27Z","timestamp":1785337587574,"version":"3.55.0"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32372276"],"award-info":[{"award-number":["32372276"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Conventional magnesium supplementation relies on passive diffusion in the small intestine, resulting in poor bioavailability. To address this, we developed an oxidized starch-chitosan-Mg2+ composite gel that directs more Mg2+ to the colon, where resistant polysaccharides are fermented to SCFAs that may actively enhance absorption. Mg2+ incorporation increased the gel\u2019s resistant component to 52.42 \u00b1 0.63%. Increasing Mg2+ from 0.5% to 2% reduced cumulative upper gastrointestinal release from 70.61 \u00b1 0.79% to 43.62 \u00b1 1.01% (p &amp;lt; 0.05), with higher concentrations showing no further improvement. In Mg2+-deficient mice, the gel dose-dependently restored serum Mg2+ to healthy levels. Comparison at equal Mg2+ doses revealed that the polysaccharide carrier independently contributed to enhanced absorption. Mechanistically, resistant polysaccharides were associated with upregulation of SCFAs receptors (FFAR2\/FFAR3\/HCAR2) and Mg2+ transporters (TRPM6\/TRPM7\/CNNM4), with immunofluorescence indicating TRPM7 upregulation. This work provides proof-of-concept evidence for a paradigm shift from passive supplementation to active regulation via SCFAs-associated transporter modulation.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c03818","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:24:38Z","timestamp":1784543078000},"page":"23140-23154","source":"Crossref","is-referenced-by-count":0,"title":["Oxidized Starch-Chitosan-Mg2+ Gel Enhances\nColonic Mg2+ Absorption in Deficient Mice with Associated\nSCFAs and Transporter Modulation"],"prefix":"10.1021","volume":"74","author":[{"given":"Qiyong","family":"Guo","sequence":"first","affiliation":[{"name":"South China University of Technology , , ,","place":["Guangzhou, China, 510640"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihang","family":"Cao","sequence":"additional","affiliation":[{"name":"South China University of Technology , , ,","place":["Guangzhou, China, 510640"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6074-523X","authenticated-orcid":true,"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"South China University of Technology , , ,","place":["Guangzhou, China, 510640"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026072910061328600_cit1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.tifs.2017.02.017","article-title":"The importance of minerals in human nutrition: Bioavailability,\nfood fortification, processing effects and nanoencapsulation","volume":"62","author":"Gharibzahedi","year":"2017","journal-title":"Trends Food Sci. 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