{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:55:31Z","timestamp":1785941731181,"version":"3.56.0"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2026AAC050023"],"award-info":[{"award-number":["2026AAC050023"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Ningxia Program for the Full-Time Recruitment of High-Level Talents","doi-asserted-by":"publisher","award":["2024BEH04001"],"award-info":[{"award-number":["2024BEH04001"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22334007, 22564018"],"award-info":[{"award-number":["22334007, 22564018"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mass spectrometry plays a key role in agricultural and food chemistry, yet direct ionization of plant samples is complicated by endogenous salts and other matrix components that destabilize conventional direct-current nanoelectrospray ionization (DC-nanoESI). To address this limitation in point-of-need analysis, we developed hand-held electrostatic spray ionization (HESSI), which produces stable ionization from nanoliter sample volumes without direct electrical contact with the solution. A compact pulsed-discharge module and dielectric barrier limit electrochemical reactions and reduce the risk of discharge at the emitter while remaining compatible with salt-containing plant extracts. Approximately 50 nL of the sample sustained MS signals for up to 5 min. In a proof-of-concept application, 208 compounds were tentatively annotated from Sophora japonica and Robinia pseudoacacia extracts in negative-ion mode, and a neural network model distinguished the two groups with an accuracy of 83.3%. These results support HESSI as a compact and sample-efficient platform for the rapid mass-spectrometric characterization of botanical materials.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c03868","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:04:06Z","timestamp":1785146646000},"page":"23914-23923","source":"Crossref","is-referenced-by-count":0,"title":["Hand-Held Electrostatic Spray Ionization Mass Spectrometry\nEnables On-Site Metabolomic Analysis of\n                    <i>Sophora japonica<\/i>\n                    and\n                    <i>Robinia pseudoacacia<\/i>"],"prefix":"10.1021","volume":"74","author":[{"given":"Mengyang","family":"Song","sequence":"first","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Ji","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Ye","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Yang","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buyin","family":"Shi","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-6856","authenticated-orcid":true,"given":"Yuze","family":"Li","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-6348","authenticated-orcid":true,"given":"Zongxiu","family":"Nie","sequence":"additional","affiliation":[{"name":"Ningxia University , , ,","place":["Yinchuan, China, 750021"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"1","key":"2026080510083650500_cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-023-00203-4","article-title":"Mass spectrometry\nusing electrospray ionization","volume":"3","author":"Prabhu","year":"2023","journal-title":"Nat. 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Chem."},{"key":"2026080510083650500_cit5","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/282574","article-title":"Electrospray Ionization\nMass Spectrometry: A Technique\nto Access the Information beyond the Molecular Weight of the Analyte","volume":"2012","author":"Banerjee","year":"2012","journal-title":"Int. J. Anal. Chem."},{"key":"2026080510083650500_cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcoa.2022.100064","article-title":"Recent advancements\nin nanoelectrospray ionization interface and coupled devices","volume":"2","author":"Chen","year":"2022","journal-title":"J. Chromatogr. Open"},{"key":"2026080510083650500_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135976","article-title":"Identification\nof the\nbotanical origins of honey based on nanoliter electrospray ionization\nmass spectrometry","volume":"418","author":"Yu","year":"2023","journal-title":"Food Chem."},{"key":"2026080510083650500_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.126824","article-title":"Desalting\nstrategies for native mass spectrometry","volume":"281","author":"Li","year":"2025","journal-title":"Talanta"},{"issue":"6","key":"2026080510083650500_cit9","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1021\/jasms.4c00099","article-title":"Probing\nMetal Ion Adduction in the\nESI Charged Residue Mechanism via Gas-Phase Ion\/Ion Chemistry","volume":"35","author":"Brundridge","year":"2024","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"1","key":"2026080510083650500_cit10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/jms.107","article-title":"Electrospray\nionization tandem mass spectrometric study of salt cluster ions. Part\n1\u2500 Investigations of alkali metal chloride and sodium salt\ncluster ions","volume":"36","author":"Hao","year":"2001","journal-title":"J. Mass Spectrom."},{"key":"2026080510083650500_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2022.116845","article-title":"High-pressure nanoESI\nof highly conductive volatile\nand non-volatile buffer solutions from a large Taylor cone: Effect\nof spray current on charge state distribution","volume":"476","author":"Han","year":"2022","journal-title":"Int. J. 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