{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:46Z","timestamp":1785463126142,"version":"3.56.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374014"],"award-info":[{"award-number":["82374014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chinese onion (Allium chinense G. Don) is a widely consumed edible vegetable across East Asia, recognized for its dual use as both a food and a medicinal resource. Its bulbs are recognized as dietary resources that are rich in bioactive steroidal saponins. This study conducted a systematic phytochemical investigation of Chinese onion bulbs, leading to the isolation of 20 steroidal saponins, including 13 previously undescribed compounds. Antiproliferative screening against gastric cancer (AGS) cells established that compound 1 possesses potent cytotoxicity. Mechanistic evaluations revealed that 1 suppressed AKT phosphorylation, triggered excessive intracellular reactive oxygen species (ROS) accumulation, and induced mitochondrial dysfunction, ultimately activating caspase-dependent apoptosis. Molecular docking and cellular thermal shift assay (CETSA) suggested a potential interaction between compound 1 and AKT. These findings significantly expand the chemical diversity of Chinese onions and highlight their steroidal saponins as promising dietary leads for gastric cancer intervention through the AKT-mediated oxidative stress and mitochondrial apoptosis pathways.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c03919","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:24:21Z","timestamp":1780518261000},"page":"18032-18050","source":"Crossref","is-referenced-by-count":0,"title":["Steroidal Saponins\nfrom the Bulbs of Chinese Onion\n(\n                    <i>Allium chinense<\/i>\n                    G. Don) and Their Antiproliferation\nPotential"],"prefix":"10.1021","volume":"74","author":[{"given":"Yantao","family":"Zu","sequence":"first","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaili","family":"Kang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-8037","authenticated-orcid":true,"given":"Jingwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Xiang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-7657","authenticated-orcid":true,"given":"Xiangjiu","family":"He","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-532X","authenticated-orcid":true,"given":"Yihai","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]},{"name":"Guangdong Pharmaceutical University , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"issue":"24","key":"2026073021163063100_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12244503","article-title":"Green onion\n(Allium fistulosum): an\naromatic vegetable crop esteemed for food, nutritional and therapeutic\nsignificance","volume":"12","author":"Kim","year":"2023","journal-title":"Foods"},{"issue":"42","key":"2026073021163063100_cit2","first-page":"40","article-title":"Chinese onion\n(Allium chinense), an\nevergreen vegetable: A brief review","volume":"42","author":"Shahrajabian","year":"2020","journal-title":"Pol. 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