{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:43:25Z","timestamp":1786538605204,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","award":["HBNYHXGG2023-3"],"award-info":[{"award-number":["HBNYHXGG2023-3"]}],"id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477040"],"award-info":[{"award-number":["22477040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Succinate dehydrogenase inhibitors (SDHIs) have emerged as one of the fastest-growing fungicides, yet their structural conservation and overuse have triggered widespread fungal resistance. Herein, we designed and synthesized a series of novel diphenyl-oxime-ether pyrazole-carboxamide derivatives by employing the fragment combination strategy. Among them, compound 8r exhibited potent SDH inhibition with an IC50 of 0.056 \u03bcM, which was approximately a 24-fold improvement over penthiopyrad (IC50 = 1.320 \u03bcM). In greenhouse trials, compounds 8t and 8z showed 50% and 40% disease control efficacy against rice sheath blight at 0.78 mg\/L, comparable to Thifluzamide (50% control efficacy at 0.78 mg\/L). Molecular modeling revealed that halogen substitution enhances intramolecular halogen bonding, stabilizing the cation-\u03c0 interaction with the C_R46 residue. This work presents a promising scaffold for novel SDHI development.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04056","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:13:16Z","timestamp":1785849196000},"page":"24653-24660","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Novel\nDiphenyl-Oxime-Ether Derivatives\nas Potent Succinate Dehydrogenase Inhibitors via Fragment Combination\nStrategy"],"prefix":"10.1021","volume":"74","author":[{"given":"Ling-Qiang","family":"Zeng","sequence":"first","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ye","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5672-5209","authenticated-orcid":true,"given":"Xiao-Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-2593","authenticated-orcid":true,"given":"Guang-Fu","family":"Yang","sequence":"additional","affiliation":[{"name":"Central China Normal University , , ,","place":["Wuhan, P. R. China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"7","key":"2026081208095318000_cit1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.cell.2005.05.025","article-title":"Crystal Structure of Mitochondrial\nRespiratory Membrane Protein Complex II","volume":"121","author":"Sun","year":"2005","journal-title":"Cell"},{"issue":"18","key":"2026081208095318000_cit2","doi-asserted-by":"publisher","first-page":"10244","DOI":"10.1021\/acs.chemrev.0c00249","article-title":"Redox Properties of the Membrane Proteins from the\nRespiratory Chain","volume":"120","author":"Melin","year":"2020","journal-title":"Chem. 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Genet."},{"issue":"3","key":"2026081208095318000_cit6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1017\/S0016672300016098","article-title":"Three genes determine the carboxin\nsensitivity of mitochondrial succinate oxidation in Aspergillus nidulans","volume":"26","author":"Gunatilleke","year":"1975","journal-title":"Genet. 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Food Chem."},{"issue":"11","key":"2026081208095318000_cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224132","article-title":"Evolutionarily conserved susceptibility of the mitochondrial\nrespiratory chain to SDHI pesticides and its consequence on the impact\nof SDHIs on human cultured cells","volume":"14","author":"Be\u0301nit","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"2026081208095318000_cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64001-0","article-title":"Cryo-EM structure of the yeast Saccharomyces cerevisiae\nSDH provides a template for eco-friendly fungicide discovery","volume":"16","author":"Li","year":"2025","journal-title":"Nat. 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