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Moringa oleifera leaves (MOL) offer metabolic benefits, but their active components and precise mechanisms against MASLD are unclear. Phytochemical isolation of MOL extract (MOLE) identified \u03b1-tocopherol (TCP) as a key constituent. TCP dose-dependently ameliorated PA-induced lipotoxicity in hepatocytes, mirroring the protective effects of MOLE against MASLD in HFC diet-fed mice. Mechanistically, TCP mitigated PA-induced mitochondrial fragmentation and oxidative stress. These effects were accompanied by improvements in the levels of mitochondrial dynamics and mitophagy regulators in PA-treated hepatocytes or the livers of MOLE-treated HFC mice, including DRP1, MFN2, OPA1, PINK1, and Parkin. This restoration of mitochondrial quality emerged as a central mechanism involving the lipotoxicity-ameliorating effects of TCP, underlying the anti-MASLD action of M. oleifera in mice. These findings provide a mechanistic basis for using MOL and TCP in managing metabolic disorders, including MASLD.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04265","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:02:25Z","timestamp":1788940945000},"page":"29189-29200","source":"Crossref","is-referenced-by-count":0,"title":["\u03b1-Tocopherol\nAlleviates Lipotoxicity\nin Hepatocytes by Rejuvenating Mitochondrial Quality, Underlying the\nMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Counteracting\nEfficacy of\n                    <i>Moringa oleifera<\/i>\n                    Leaves\nin Mice"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8725-274X","authenticated-orcid":true,"given":"Feifei","family":"Liu","sequence":"first","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dong","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Xu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Cao","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8372-6670","authenticated-orcid":true,"given":"Zhongping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Rao","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2462-7935","authenticated-orcid":true,"given":"Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570200"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"7","key":"2026092310071524000_cit1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3748\/wjg.v30.i7.652","article-title":"Recent advances in\nage-related metabolic dysfunction-associated steatotic\nliver disease","volume":"30","author":"He","year":"2024","journal-title":"World J. 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