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C-LPE3 relieved colitis symptoms, restored intestinal barrier integrity via upregulating tight junction proteins and Muc-2, and suppressed inflammation and oxidative stress by activating AMPK while inhibiting the mTOR\/NF-\u03baB cascade. It reshaped dysbiotic gut microbiota, elevated short-chain fatty acids, and boosted l-arginine biosynthesis by increasing Argininosuccinate Synthase 1 (ASS1)\/Argininosuccinate Lyase (ASL) expression. In vitro assays confirmed l-arginine alleviated macrophage inflammation through the AMPK-mTOR\/NF-\u03baB axis. Correlation analysis linked C-LPE3-enriched beneficial microbes to higher l-arginine and SCFA levels. Collectively, C-LPE3 mitigates colitis through a microbiota-l-arginine-AMPK regulatory axis, supporting its development as a gut-health functional food ingredient.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04286","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:01:47Z","timestamp":1786478507000},"page":"26236-26255","source":"Crossref","is-referenced-by-count":0,"title":["An Exopolysaccharide\nfrom\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    ZGS521 Alleviates Colitis via Gut Microbiota\nModulation and Enhanced Arginine Biosynthesis"],"prefix":"10.1021","volume":"74","author":[{"given":"Wei","family":"Xia","sequence":"first","affiliation":[{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]},{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]},{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Academy of Agricultural Sciences , , , ,","place":["Hangzhou, Zhejiang, PR China, 310021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui-Wu","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]},{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-3639","authenticated-orcid":true,"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]},{"name":"Zhejiang Gongshang University , , Xiasha, , ,","place":["Hangzhou, Zhejiang, PR China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026090104483920400_cit1","doi-asserted-by":"publisher","first-page":"140346","DOI":"10.1016\/j.foodchem.2024.140346","article-title":"Anti-inflammation mechanisms of a homogeneous polysaccharide from\nPhyllanthus emblica L. on DSS induced colitis mice via the gut microbiota\nand metabolites alteration","volume":"459","author":"Li","year":"2024","journal-title":"Food Chem."},{"issue":"10401","key":"2026090104483920400_cit2","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative\ncolitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"2026090104483920400_cit3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1136\/gutjnl-2015-309333","article-title":"Dysbiotic gut microbiota\ncauses transmissible Crohn\u2019s disease-like ileitis independent\nof failure in antimicrobial defence","volume":"65","author":"Schaubeck","year":"2016","journal-title":"Gut"},{"key":"2026090104483920400_cit4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.foodhyd.2018.11.049","article-title":"Structure characterization of a polysaccharide\nextracted from noni\n(Morinda citrifolia L.) and its protective effect against DSS-induced\nbowel disease in mice","volume":"90","author":"Jin","year":"2019","journal-title":"Food Hydrocolloids"},{"issue":"11","key":"2026090104483920400_cit5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3390\/antiox8110512","article-title":"Gastro-Protective and Anti-Oxidant\nPotential of Althaea\nofficinalis and Solanum nigrum on Pyloric Ligation\/Indomethacin-Induced\nUlceration in Rats","volume":"8","author":"Zaghlool","year":"2019","journal-title":"Antioxidants"},{"key":"2026090104483920400_cit6","doi-asserted-by":"publisher","first-page":"113192","DOI":"10.1016\/j.foodres.2023.113192","article-title":"Natural polysaccharides\nprotect against diet-induced obesity by improving lipid metabolism\nand regulating the immune system","volume":"172","author":"Tang","year":"2023","journal-title":"Food Res.\nInt."},{"issue":"29","key":"2026090104483920400_cit7","doi-asserted-by":"publisher","first-page":"16347","DOI":"10.1021\/acs.jafc.4c04024","article-title":"Intracellular\nPolysaccharides of Eurotium cristatum Exhibited Anticolitis\nEffects in Association with Gut Tryptophan Metabolism","volume":"72","author":"Zhang","year":"2024","journal-title":"J. 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