{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:49:39Z","timestamp":1791391779807,"version":"4.3.3"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100015789","name":"Dalian High-Level Talent Innovation Program","doi-asserted-by":"publisher","award":["2023RG005"],"award-info":[{"award-number":["2023RG005"]}],"id":[{"id":"10.13039\/100015789","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xingliao Talent Program","award":["XLYC2403202"],"award-info":[{"award-number":["XLYC2403202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Yeast protein-derived high Fischer ratio peptides (HFYP) show great potential for alleviating exercise-induced fatigue, yet existing studies have focused only on skeletal muscle regulation, overlooking the muscle-liver axis in systemic lactate metabolism. We optimized HFYP preparation via response surface methodology, yielding peptides with a Fischer ratio of 40.01 and 23.95% BCAA content. Low-dose HFYP (0.128 g\/kg) prolonged exhaustive swimming time from 9.53 to 29.88 min (3.1-fold), outperforming taurine (16.89 min) and BCAA-matched amino acid mixtures (22.25 and 18.78 min). Mechanistically, HFYP activated AMPK\/PGC-1\u03b1 and AKT\/FOXO1 pathways in muscle to promote mitochondrial biogenesis and glucose utilization, while upregulating hepatic PCK1 to enhance Cori cycle activity. HFYP alleviates exercise-induced fatigue through the synergistic regulation of skeletal muscle lactate metabolism and hepatic lactate-to-glucose recycling via the muscle-liver axis, which provides a solid theoretical basis for the high-value utilization of yeast protein and the development of HFYP-based antifatigue functional foods.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04340","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:02:24Z","timestamp":1790175744000},"page":"30756-30767","source":"Crossref","is-referenced-by-count":0,"title":["Yeast Protein-Derived\nHigh Fischer Ratio Peptides\nExert Superior Anti-Fatigue Efficacy to Amino Acid Mixtures by Regulating\nMuscle-Liver Axis Lactate Metabolism"],"prefix":"10.1021","volume":"74","author":[{"given":"Xiaoyu","family":"Ma","sequence":"first","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Liaoning Jinhong Yili Dairy Co., Ltd. , ,","place":["Shenyang, China, 110413"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Du","sequence":"additional","affiliation":[{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Dalian Polytechnic University , , ,","place":["Dalian, China, 116034"]},{"name":"Dalian Ocean University , , ,","place":["Dalian, China, 116023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026100711071066600_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.101298","article-title":"Natural bioactive peptides to beat exercise-induced fatigue: A review","volume":"43","author":"Wang","year":"2021","journal-title":"Food Biosci."},{"issue":"8","key":"2026100711071066600_cit2","doi-asserted-by":"publisher","first-page":"6612","DOI":"10.1021\/acs.jafc.5c14044","article-title":"Mushroom\nPolysaccharides as Functional Food Ingredients for Alleviating Exercise-Induced\nFatigue: A Review of Efficacy, Mechanisms, and Structure-Function\nRelationships","volume":"74","author":"Xie","year":"2026","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"2026100711071066600_cit3","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s12276-022-00802-3","article-title":"Tracing the lactate shuttle to the\nmitochondrial reticulum","volume":"54","author":"Brooks","year":"2022","journal-title":"Exp. Mol. 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Physiol.,\nNutr., Metab."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c04340","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/39\/30756\/68620244\/acs.jafc.6c04340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/39\/30756\/68620244\/acs.jafc.6c04340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:50:41Z","timestamp":1791388241000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/39\/30756\/5436545\/Yeast-Protein-Derived-High-Fischer-Ratio-Peptides"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":30,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,23]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c04340","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}