{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:34:12Z","timestamp":1787150052514,"version":"build-2736575974"},"reference-count":103,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200154"],"award-info":[{"award-number":["32200154"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Jiangsu Basic Research Center for Synthetic Biology Grant","doi-asserted-by":"publisher","award":["BK20233003"],"award-info":[{"award-number":["BK20233003"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Selenium deficiency poses a global health concern, yet traditional supplements face limitations in bioavailability and safety. Probiotics-derived selenium nanoparticles (SeNPs) offer a promising alternative. This review summarizes the biosynthesis mechanisms of SeNPs by probiotics, key factors influencing their particle size, and their core biological activities, including antioxidant, antibacterial, and immunomodulatory effects. It also evaluates their application potential in functional foods and aquaculture. Despite advantages in biocompatibility and bioactivity, challenges remain in industrial-scale production and standardization. This paper highlights the promise of probiotics-derived SeNPs and emphasizes the need for process optimization and safety assessment to advance their application in nutrition and health.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04376","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T17:04:26Z","timestamp":1785949466000},"page":"24781-24795","source":"Crossref","is-referenced-by-count":0,"title":["Probiotics-Derived\nSelenium Nanoparticles: A Novel\nFood Additive"],"prefix":"10.1021","volume":"74","author":[{"given":"Xiaoya","family":"Sheng","sequence":"first","affiliation":[{"name":"Nanjing Normal University , , 2 Xuelin Road , Qixia District, , ,","place":["Nanjing, Jiangsu, China, 210097"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Deng","sequence":"additional","affiliation":[{"name":"Nanjing Normal University , , 2 Xuelin Road , Qixia District, , ,","place":["Nanjing, Jiangsu, China, 210097"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanjing Normal University , , 2 Xuelin Road , Qixia District, , ,","place":["Nanjing, Jiangsu, China, 210097"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Nanjing Normal University , , 2 Xuelin Road , Qixia District, , ,","place":["Nanjing, Jiangsu, China, 210097"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2891","authenticated-orcid":true,"given":"Jingpeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanjing Normal University , , 2 Xuelin Road , Qixia District, , ,","place":["Nanjing, Jiangsu, China, 210097"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"1","key":"2026081910144584100_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30010050","article-title":"Effects and Impact\nof Selenium on Human Health, A Review","volume":"30","author":"Bai","year":"2025","journal-title":"Molecules"},{"key":"2026081910144584100_cit2","doi-asserted-by":"crossref","DOI":"10.17226\/9810","volume-title":"Dietary Reference Intakes\nfor Vitamin C, Vitamin E, Selenium, and Carotenoids","author":"Institute of Medicine Panel on Dietary Antioxidants and Related Compounds.","year":"2000"},{"issue":"24","key":"2026081910144584100_cit3","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1001\/jama.1996.03540240035027","article-title":"Effects of selenium supplementation\nfor cancer prevention in patients with carcinoma of the skin. A randomized\ncontrolled trial. Nutritional Prevention of Cancer Study Group","volume":"276","author":"Clark","year":"1996","journal-title":"JAMA"},{"key":"2026081910144584100_cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1136458","article-title":"Review on the health-promoting effect\nof adequate selenium status","volume":"10","author":"Sun","year":"2023","journal-title":"Front. Nutr."},{"key":"2026081910144584100_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169619","article-title":"Impacts, causes and\nbiofortification strategy of rice selenium deficiency\nbased on publication collection","volume":"912","author":"Ma","year":"2024","journal-title":"Sci. Total\nEnviron."},{"issue":"2","key":"2026081910144584100_cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-024-02349-w","article-title":"Spatial distribution\nand driving factors of soil selenium on the Leizhou Peninsula, southern\nChina","volume":"47","author":"Cheng","year":"2025","journal-title":"Environ. Geochem. Health"},{"key":"2026081910144584100_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gexplo.2020.106654","article-title":"Concentration and\ndistribution of selenium in soils of mainland China, and implications\nfor human health","volume":"220","author":"Liu","year":"2021","journal-title":"J. Geochem. Explor."},{"key":"2026081910144584100_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.144103","article-title":"Status and\nrisks of selenium deficiency in a traditional selenium-deficient\narea in Northeast China","volume":"762","author":"Yang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"2026081910144584100_cit9","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev-nutr-062320-121834","article-title":"Dietary Selenium Across Species","volume":"42","author":"Lei","year":"2022","journal-title":"Annu. Rev. Nutr."},{"issue":"7","key":"2026081910144584100_cit10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076068","article-title":"Physiological\nBenefits of Novel Selenium Delivery via Nanoparticles","volume":"24","author":"Au","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026081910144584100_cit11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jddst.2018.05.023","article-title":"Selenium\nnanomaterials in biomedicine-An\noverview of new opportunities in nanomedicine of selenium","volume":"46","author":"Sakr","year":"2018","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"10","key":"2026081910144584100_cit12","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.freeradbiomed.2007.02.013","article-title":"Elemental\nselenium at nano size possesses\nlower toxicity without compromising the fundamental effect on selenoenzymes:\ncomparison with selenomethionine in mice","volume":"42","author":"Wang","year":"2007","journal-title":"Free\nRadic. Biol. Med."},{"issue":"1","key":"2026081910144584100_cit13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/toxsci\/kfm221","article-title":"Elemental\nselenium at nano size (Nano-Se)\nas a potential chemopreventive agent with reduced risk of selenium\ntoxicity: comparison with se-methylselenocysteine in mice","volume":"101","author":"Zhang","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"1","key":"2026081910144584100_cit14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3109\/13880209.2012.710241","article-title":"Acute and\nsubacute toxicity of novel\nbiogenic selenium nanoparticles in mice","volume":"51","author":"Shakibaie","year":"2013","journal-title":"Pharm.\nBiol."},{"issue":"21","key":"2026081910144584100_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/foods14213640","article-title":"Recent Advances Towards\nSelenium Nanoparticles: Synthetic Methods, Functional Mechanisms,\nand Biological Applications","volume":"14","author":"Geng","year":"2025","journal-title":"Foods"},{"issue":"1","key":"2026081910144584100_cit16","doi-asserted-by":"publisher","DOI":"10.1080\/17518253.2025.2488237","article-title":"A review on synthesis\nand characterization of selenium nanoparticles from plant extracts\nfor applications in agriculture, biomedicine, and environment","volume":"18","author":"Alsafran","year":"2025","journal-title":"Green Chem. Lett. Rev."},{"key":"2026081910144584100_cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.102946","article-title":"Selenium\nnanoparticles: Eco-friendly synthesis, biological activities and biomedical\napplications - A comprehensive review","volume":"37","author":"El-Saadony","year":"2026","journal-title":"Mater.\nToday Bio"},{"key":"2026081910144584100_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128834","article-title":"Novel mechanisms of\nselenite reduction in Bacillus subtilis 168:Confirmation of multiple-pathway\nmediated remediation based on transcriptome analysis","volume":"433","author":"Jia","year":"2022","journal-title":"J. Hazard Mater."},{"issue":"3","key":"2026081910144584100_cit19","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/10408398.2021.1948818","article-title":"Recent development in Se-enriched\nyeast, lactic acid bacteria and\nbifidobacteria","volume":"63","author":"Yang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"2026081910144584100_cit20","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.carbpol.2018.04.110","article-title":"Preparation,\ncharacteristics and antioxidant activity of polysaccharides and proteins-capped\nselenium nanoparticles synthesized by Lactobacillus casei ATCC 393","volume":"195","author":"Xu","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"33","key":"2026081910144584100_cit21","doi-asserted-by":"publisher","first-page":"13480","DOI":"10.1073\/pnas.1105959108","article-title":"A bacterial process\nfor selenium nanosphere assembly","volume":"108","author":"Debieux","year":"2011","journal-title":"Proc. Natl.\nAcad. Sci. U.S.A."},{"issue":"23","key":"2026081910144584100_cit22","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300432","article-title":"Advances in\nthe Study of Selenium-Enriched\nProbiotics: From the Inorganic Se into Se Nanoparticles","volume":"67","author":"Xiao","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"2026081910144584100_cit23","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1093\/genetics\/145.3.627","article-title":"Molecular characterization of two high affinity sulfate\ntransporters in Saccharomyces cerevisiae","volume":"145","author":"Cherest","year":"1997","journal-title":"Genetics"},{"issue":"42","key":"2026081910144584100_cit24","doi-asserted-by":"publisher","first-page":"32029","DOI":"10.1074\/jbc.M110.139865","article-title":"Uptake of selenite by Saccharomyces cerevisiae involves\nthe high and low affinity orthophosphate transporters","volume":"285","author":"Lazard","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"22","key":"2026081910144584100_cit25","doi-asserted-by":"publisher","first-page":"3934","DOI":"10.1091\/mbc.e10-06-0513","article-title":"Jen1p: a high\naffinity selenite transporter\nin yeast","volume":"21","author":"McDermott","year":"2010","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"2026081910144584100_cit26","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1515\/bmc-2013-0033","article-title":"Selenomethionine metabolism\nand its toxicity in yeast","volume":"4","author":"Kitajima","year":"2013","journal-title":"Biomol. Concepts"},{"issue":"13","key":"2026081910144584100_cit27","doi-asserted-by":"publisher","first-page":"5373","DOI":"10.1007\/s00253-015-6650-x","article-title":"Accumulation\nand metabolism of selenium by yeast cells","volume":"99","author":"Kieliszek","year":"2015","journal-title":"Appl.\nMicrobiol. Biotechnol."},{"issue":"12","key":"2026081910144584100_cit28","doi-asserted-by":"publisher","first-page":"8759","DOI":"10.1074\/jbc.M610078200","article-title":"Extracellular production\nof hydrogen selenide accounts for thiol-assisted toxicity of selenite\nagainst Saccharomyces cerevisiae","volume":"282","author":"Tarze","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026081910144584100_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102917","article-title":"Glutathione and peroxisome redox\nhomeostasis","volume":"67","author":"Ferreira","year":"2023","journal-title":"Redox Biol."},{"issue":"12","key":"2026081910144584100_cit30","doi-asserted-by":"publisher","first-page":"8030","DOI":"10.1016\/S0021-9258(18)42403-9","article-title":"Selenodiglutathione\nis a highly efficient\noxidant of reduced thioredoxin and a substrate for mammalian thioredoxin\nreductase","volume":"267","author":"Bjo\u0308rnstedt","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"1","key":"2026081910144584100_cit31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1042\/BJ20100368","article-title":"Selenium\ncompounds are substrates for glutaredoxins: a novel pathway for selenium\nmetabolism and a potential mechanism for selenium-mediated cytotoxicity","volume":"429","author":"Wallenberg","year":"2010","journal-title":"Biochem. J."},{"key":"2026081910144584100_cit32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.procbio.2023.03.025","article-title":"Assembly of selenium nanoparticles by protein coronas\ncomposed of yeast protease A","volume":"129","author":"Nie","year":"2023","journal-title":"Process Biochem."},{"issue":"6","key":"2026081910144584100_cit33","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1021\/acs.est.2c07028","article-title":"Uptake of Selenite by Rahnella aquatilis\nHX2 Involves the Aquaporin\nAqpZ and Na(+)\/H(+) Antiporter NhaA","volume":"57","author":"Xu","year":"2023","journal-title":"Environ.\nSci. Technol."},{"issue":"3","key":"2026081910144584100_cit34","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1023\/A:1009290213301","article-title":"Selenium metabolism in Escherichia coli","volume":"11","author":"Turner","year":"1998","journal-title":"BioMetals"},{"key":"2026081910144584100_cit35","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biochi.2025.02.005","article-title":"Molecular\nmechanism of selenite reduction by Bacillus amyloliquefaciens BB61\nbased on transcriptome analysis","volume":"233","author":"Wang","year":"2025","journal-title":"Biochimie"},{"issue":"1","key":"2026081910144584100_cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-026-01901-3","article-title":"Biogenic synthesis and transcriptomic\ninsights into selenium nanoparticle formation by Lactiplantibacillus\nplantarum SMB14 isolated from goat manure","volume":"57","author":"Zhang","year":"2026","journal-title":"Braz\nJ. Microbiol."},{"issue":"8","key":"2026081910144584100_cit37","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.1128\/AEM.00568-06","article-title":"Resolution of distinct\nmembrane-bound enzymes from Enterobacter cloacae SLD1a-1 that are\nresponsible for selective reduction of nitrate and selenate oxyanions","volume":"72","author":"Ridley","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"issue":"3","key":"2026081910144584100_cit38","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00659-23","article-title":"Selenite Bioremediation\nby Food-Grade Probiotic Lactobacillus casei\nATCC 393: Insights from Proteomics Analysis","volume":"11","author":"Qiao","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"2026081910144584100_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107318","article-title":"Efficiently\nsynthetic pathways of selenium nanoparticles in a probiotic and their\nmixture as a new dietary antioxidant supplement","volume":"71","author":"Liu","year":"2025","journal-title":"Food Biosci."},{"key":"2026081910144584100_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139595","article-title":"Bioreduction of Se(IV) by Lactiplantibacillus plantarum NML21 and\nsynthesis of selenium nanospheres Se(0)","volume":"452","author":"Wang","year":"2024","journal-title":"Food\nChem."},{"key":"2026081910144584100_cit41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.18488\/journal.57.2021.101.39.51","article-title":"Antibacterial\nActivity of Intracellular\nGreenly Fabricated Selenium Nanoparticle of Lactobacillus pentosus\nADET MW861694 against Selected Food Pathogens","volume":"10","author":"Adebayo-Tayo","year":"2021","journal-title":"Int. J. Biotechnol."},{"key":"2026081910144584100_cit42","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.talanta.2017.06.013","article-title":"Proteins in microbial\nsynthesis of selenium nanoparticles","volume":"174","author":"Tugarova","year":"2017","journal-title":"Talanta"},{"issue":"1","key":"2026081910144584100_cit43","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-13-35","article-title":"Delayed formation of\nzero-valent selenium nanoparticles\nby Bacillus mycoides SeITE01 as a consequence of selenite reduction\nunder aerobic conditions","volume":"13","author":"Lampis","year":"2014","journal-title":"Microb. Cell Fact."},{"key":"2026081910144584100_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125545","article-title":"Highly stable\nselenium nanoparticles: Assembly and stabilization\nvia flagellin FliC and porin OmpF in Rahnella aquatilis HX2","volume":"414","author":"Li","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"2026081910144584100_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134491","article-title":"Reduction of selenite to selenium nanoparticles by highly selenite-tolerant\nbacteria isolated from seleniferous soil","volume":"472","author":"Ge","year":"2024","journal-title":"J.\nHazard. Mater."},{"issue":"9","key":"2026081910144584100_cit46","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093793","article-title":"Biological\nSelenite Reduction, Characterization and Bioactivities of Selenium\nNanoparticles Biosynthesised by Pediococcus acidilactici DSM20284","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"2026081910144584100_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107165","article-title":"Effects of selenium\nnanoparticles produced by Lactobacillus acidophilus HN23 on lipid\ndeposition in WRL68 cells","volume":"145","author":"Lei","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"11","key":"2026081910144584100_cit48","doi-asserted-by":"publisher","first-page":"13439","DOI":"10.1021\/acsami.3c16340","article-title":"Stabilization by Chaperone\nGroEL in Biogenic Selenium Nanoparticles Produced from Bifidobacterium\nanimalis H15 for the Treatment of DSS-Induced Colitis","volume":"16","author":"Li","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"2026081910144584100_cit49","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121204","article-title":"Highly Efficient Biotransformation and Production of Selenium Nanoparticles\nand Polysaccharides Using Potential Probiotic Bacillus subtilis T5","volume":"12","author":"Duan","year":"2022","journal-title":"Metabolites"},{"issue":"2","key":"2026081910144584100_cit50","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.sjbs.2021.09.046","article-title":"Antioxidant and antimicrobial activities\nof Spirulina platensis extracts and biogenic selenium nanoparticles\nagainst selected pathogenic bacteria and fungi","volume":"29","author":"Abdel-Moneim","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"2026081910144584100_cit51","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1015613","article-title":"Green nanotechnology for controlling\nbacterial load\nand heavy metal accumulation in Nile tilapia fish using biological\nselenium nanoparticles biosynthesized by Bacillus subtilis AS12","volume":"13","author":"Saad","year":"2022","journal-title":"Front. Microbiol."},{"issue":"18","key":"2026081910144584100_cit52","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26185559","article-title":"Biosynthesis of Selenium\nNanoparticles (via Bacillus\nsubtilis BSN313), and Their Isolation, Characterization, and Bioactivities","volume":"26","author":"Ullah","year":"2021","journal-title":"Molecules"},{"key":"2026081910144584100_cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2024.127402","article-title":"In vitro digestion\nand characterization of selenized\nSaccharomyces cerevisiae, Pichia fermentans and probiotic Saccharomyces\nboulardii","volume":"83","author":"Hyrslova","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"2","key":"2026081910144584100_cit54","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s10876-020-01794-8","article-title":"Antibacterial,\nCytotoxicity and Larvicidal\nActivity of Green Synthesized Selenium Nanoparticles Using Penicillium\ncorylophilum","volume":"32","author":"Salem","year":"2021","journal-title":"J. Cluster Sci."},{"issue":"10","key":"2026081910144584100_cit55","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1007\/s12011-020-02506-z","article-title":"Biomedical Applications\nof Mycosynthesized Selenium Nanoparticles Using Penicillium expansum\nATTC 36200","volume":"199","author":"Hashem","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"2026081910144584100_cit56","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1021\/es5043063","article-title":"Extracellular\npolymeric substances govern the surface charge of biogenic elemental\nselenium nanoparticles","volume":"49","author":"Jain","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"2026081910144584100_cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2024.127448","article-title":"Characterizations\nof biogenic selenium nanoparticles and their anti-biofilm potential\nagainst Streptococcus mutans ATCC 25175","volume":"84","author":"Si","year":"2024","journal-title":"J.\nTrace Elem. Med. Biol."},{"issue":"7","key":"2026081910144584100_cit58","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s10123-025-00653-8","article-title":"Screening, characterization, and potential anti-hangover ability\nof selenium nanoparticle-enriched lactobacillus","volume":"28","author":"Gao","year":"2025","journal-title":"Int. Microbiol."},{"issue":"1","key":"2026081910144584100_cit59","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.aaf.2023.05.008","article-title":"Characterization\nof selenium nanoparticles extracted from Bacillus subtilis and its\nantibacterial effects in Onychostoma macrolepis: Insight into ferroptosis","volume":"10","author":"Zhu","year":"2025","journal-title":"Aquacult. Fish."},{"issue":"5","key":"2026081910144584100_cit60","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s00203-020-01831-0","article-title":"Nanobiotechnology\napproach in intracellular\nselenium nanoparticle synthesis using Saccharomyces cerevisiae-fabrication\nand characterization","volume":"202","author":"Faramarzi","year":"2020","journal-title":"Arch. Microbiol."},{"key":"2026081910144584100_cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134204","article-title":"Multi-pathways-mediated mechanisms\nof selenite reduction and elemental selenium nanoparticles biogenesis\nin the yeast-like fungus Aureobasidium melanogenum I15","volume":"470","author":"Xue","year":"2024","journal-title":"J. Hazard Mater."},{"key":"2026081910144584100_cit62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.nbt.2020.02.003","article-title":"Selenite reduction\nby the rhizobacterium Azospirillum brasilense, synthesis of extracellular\nselenium nanoparticles and their characterisation","volume":"58","author":"Tugarova","year":"2020","journal-title":"New Biotechnol."},{"key":"2026081910144584100_cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.hazl.2025.100172","article-title":"Mechanism of selenite\nreduction in\nBacillus subtilis SR41: Role of thioredoxin reductase and threshold-driven\ntranscriptomic response","volume":"7","author":"Cheng","year":"2026","journal-title":"J. Hazard. Mater. Lett."},{"key":"2026081910144584100_cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.133850","article-title":"Molecular\nmechanisms of selenite reduction by Lactiplantibacillus plantarum\nBSe: An integrated genomic and transcriptomic analysis","volume":"468","author":"Zhong","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"41","key":"2026081910144584100_cit65","doi-asserted-by":"publisher","first-page":"17320","DOI":"10.1039\/C5NR04097C","article-title":"Progress toward clonable inorganic nanoparticles","volume":"7","author":"Ni","year":"2015","journal-title":"Nanoscale"},{"key":"2026081910144584100_cit66","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6635297","article-title":"Green Synthesis\nof Selenium Nanoparticles by Cyanobacterium Spirulina platensis (abdf2224):\nCultivation Condition Quality Controls","volume":"2021","author":"Alipour","year":"2021","journal-title":"Biomed.\nRes. Int."},{"key":"2026081910144584100_cit67","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.2147\/IJN.S247426","article-title":"Selenium Nanoparticles Synthesized\nUsing Pseudomonas stutzeri (MH191156) Show Antiproliferative and Anti-angiogenic\nActivity Against Cervical Cancer Cells","volume":"15","author":"Rajkumar","year":"2020","journal-title":"Int.\nJ. Nanomed."},{"key":"2026081910144584100_cit68","doi-asserted-by":"publisher","first-page":"815","DOI":"10.2147\/IJN.S28538","article-title":"Impact of heat treatment\non size, structure, and bioactivity of elemental selenium nanoparticles","volume":"7","author":"Zhang","year":"2012","journal-title":"Int. J. Nanomed."},{"issue":"5","key":"2026081910144584100_cit69","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1007\/s12010-022-03809-8","article-title":"Bio-fabrication\nof Selenium Nanoparticles Using Baker\u2019s Yeast Extract and Its\nAntimicrobial Efficacy on Food Borne Pathogens","volume":"194","author":"Salem","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"2026081910144584100_cit70","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.procbio.2022.12.031","article-title":"An elucidative\nstudy of the anti-biofilm\neffect of selenium nanoparticles (SeNPs) on selected biofilm producing\npathogenic bacteria: A disintegrating effect of SeNPs on bacteria","volume":"126","author":"Ullah","year":"2023","journal-title":"Process Biochem."},{"key":"2026081910144584100_cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2024.127448","article-title":"Characterizations\nof biogenic selenium nanoparticles and their anti-biofilm potential\nagainst Streptococcus mutans ATCC 25175","volume":"84","author":"Si","year":"2024","journal-title":"J.\nTrace Elem. Med. Biol."},{"issue":"1","key":"2026081910144584100_cit72","doi-asserted-by":"publisher","DOI":"10.1038\/s41538-022-00145-3","article-title":"Dietary supplementation\nwith biogenic selenium nanoparticles alleviate\noxidative stress-induced intestinal barrier dysfunction","volume":"6","author":"Qiao","year":"2022","journal-title":"NPJ Sci. Food"},{"issue":"14","key":"2026081910144584100_cit73","doi-asserted-by":"publisher","first-page":"14213","DOI":"10.1021\/acsnano.5c00574","article-title":"Triple-Functional Probiotics with\nIntracellularly Synthesized Selenium Nanoparticles for Colitis Therapy\nby Regulating the Macrophage Phenotype and Modulating Gut Microbiota","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"key":"2026081910144584100_cit74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1116223","article-title":"Nano selenium-enriched\nprobiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific\nsystemic and mucosal immunity","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"2026081910144584100_cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123117","article-title":"Anaerobic\nprobiotics-in situ Se nanoradiosensitizers selectively anchor to tumor\nwith immuno-regulations for robust cancer radio-immunotherapy","volume":"318","author":"Yu","year":"2025","journal-title":"Biomaterials"},{"issue":"9","key":"2026081910144584100_cit76","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1039\/D0NA00984A","article-title":"Biogenic selenium\nnanoparticles produced by Lactobacillus casei ATCC 393 inhibit colon\ncancer cell growth in vitro and in vivo","volume":"3","author":"Spyridopoulou","year":"2021","journal-title":"Nanoscale\nAdv."},{"issue":"4","key":"2026081910144584100_cit77","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1007\/s12013-024-01356-z","article-title":"Exploring\nthe Anti-Inflammatory and Antioxidative Potential of Selenium Nanoparticles\nBiosynthesized by Lactobacillus casei 393 on an Inflamed Caco-2 Cell\nLine","volume":"82","author":"Sendani","year":"2024","journal-title":"Cell Biochem. Biophys."},{"issue":"9","key":"2026081910144584100_cit78","doi-asserted-by":"publisher","DOI":"10.3390\/ma14092257","article-title":"Nano Selenium-Enriched\nProbiotics as Functional Food Products against Cadmium Liver Toxicity","volume":"14","author":"Vicas","year":"2021","journal-title":"Materials"},{"key":"2026081910144584100_cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131713","article-title":"Selenium-mediated Cr(VI)\nreduction\nand SeNPs synthesis accelerated Bacillus cereus SES to remediate Cr\ncontamination","volume":"457","author":"Nie","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"2026081910144584100_cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.124356","article-title":"Mitigating cadmium\nexposure risk in rice with foliar nano-selenium: Investigations through\nCaco-2 human cell line in-vivo bioavailability assay","volume":"356","author":"Hussain","year":"2024","journal-title":"Environ. Pollut."},{"issue":"16","key":"2026081910144584100_cit81","doi-asserted-by":"publisher","first-page":"6900","DOI":"10.1021\/acs.est.3c10506","article-title":"Foliar Application\nof Nanoparticles Reduced Cadmium Content in Wheat (Triticum aestivum\nL.) Grains via Long-Distance \u2033Leaf-Root-Microorganism\u2033\nRegulation","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"2026081910144584100_cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107749","article-title":"From selenium tolerance to nanoplastic antagonism:\nComprehensive characterization of L. casei SNUT1 and its extracellular\nvesicle-nanoselenium complex","volume":"74","author":"Gong","year":"2025","journal-title":"Food Biosci."},{"key":"2026081910144584100_cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116914","article-title":"Prophylactic supplementation with\nselenium nanoparticles protects against foodborne toxin zearalenone-induced\nintestinal barrier dysfunction","volume":"284","author":"Qiao","year":"2024","journal-title":"Ecotoxicol.\nEnviron. Saf."},{"key":"2026081910144584100_cit84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12011-026-05103-8","article-title":"Selenized\nProbiotic L. brevis 23017 Alleviates Colitis by Modulating the Nrf2-GPX4\nAxis to Inhibit Ferroptosis","volume":"204","author":"Zhuang","year":"2026","journal-title":"Biol. Trace Elem.\nRes."},{"issue":"2","key":"2026081910144584100_cit85","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2478\/aoas-2025-0076","article-title":"Modulatory Effects of Probiotics\nor Bio-Selenium Nanoparticles\non Performance, Immunity, Redox Balance, and Microbial Load in Acrylamide-Challenged\nOreochromis niloticus","volume":"26","author":"Mohamed","year":"2026","journal-title":"Ann. Anim. Sci."},{"issue":"5","key":"2026081910144584100_cit86","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s10876-019-01705-6","article-title":"Synthesis of Selenium Nanoparticles Using Probiotic\nBacteria Lactobacillus acidophilus and Their Enhanced Antimicrobial\nActivity Against Resistant Bacteria","volume":"31","author":"Alam","year":"2020","journal-title":"J. Cluster\nSci."},{"issue":"4","key":"2026081910144584100_cit87","doi-asserted-by":"publisher","DOI":"10.1002\/efd2.70074","article-title":"Characteristics Analysis\nand Intestinal Effects of Probiotic-Derived Nano-Selenium by Lactobacillus\nbulgaricus CICC 20247","volume":"6","author":"Wang","year":"2025","journal-title":"Efood"},{"issue":"23","key":"2026081910144584100_cit88","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01636-21","article-title":"Protective Effects of Selenium Nanoparticle-Enriched Lactococcus\nlactis NZ9000 against Enterotoxigenic Escherichia coli K88-Induced Intestinal Barrier Damage in Mice","volume":"87","author":"Chen","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"issue":"3","key":"2026081910144584100_cit89","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1007\/s12602-023-10081-7","article-title":"Impact of\nSelenium Nanoparticle-Enriched Lactobacilli Feeding Against Escherichia coli O157:H7 Infection of BALB\/c Mice","volume":"16","author":"Esfandiari","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"2026081910144584100_cit90","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.2147\/IJN.S374024","article-title":"Selenium Nanoparticles-Enriched\nLactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice\nThrough Modulating Microbiota-Gut-Brain Axis","volume":"17","author":"Qiao","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"2026081910144584100_cit91","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-025-04255-5","article-title":"Microbial Selenization as a Strategy\nto Deliver Selenium and Selenium Nanoparticles in Mango-Passion Fruit\nJuice Fermented by Indigenous Lactic Acid Bacteria","volume":"82","author":"Crespo","year":"2025","journal-title":"Curr. Microbiol."},{"issue":"10","key":"2026081910144584100_cit92","doi-asserted-by":"publisher","DOI":"10.3390\/biology11101523","article-title":"Selenium Nanoparticle-Enriched and\nPotential Probiotic,\nLactiplantibacillus plantarum S14 Strain, a Diet Supplement Beneficial\nfor Rainbow Trout","volume":"11","author":"Yanez-Lemus","year":"2022","journal-title":"Biology"},{"key":"2026081910144584100_cit93","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2025.117441","article-title":"Chitosan derived nano-selenium\nbased coatings for postharvest safety of cherry tomato","volume":"217","author":"Li","year":"2025","journal-title":"LWT"},{"issue":"6","key":"2026081910144584100_cit94","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.1007\/s11694-021-01088-1","article-title":"Whey protein\ncoating incorporated\nwith essential oil, bioactive peptides and nanoparticle extends shelf-life\nof chicken breast slices","volume":"15","author":"Karimi-Dehkordi","year":"2021","journal-title":"J. Food Meas. Charact."},{"key":"2026081910144584100_cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.117400","article-title":"Optimizing\nselenium biofortification in Camellia sinensis: A meta-analysis of\nfertilization strategies, cultivar selection, and harvest timing on\ntea Se accumulation and quality","volume":"221","author":"Li","year":"2025","journal-title":"Food Res. Int."},{"issue":"1","key":"2026081910144584100_cit96","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-024-03410-5","article-title":"Optimization of fermentation\nparameters to improve the biosynthesis\nof selenium nanoparticles by Bacillus licheniformis F1 and its comprehensive\napplication","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Microbiol."},{"issue":"1","key":"2026081910144584100_cit97","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29737-z","article-title":"Development\nand application of a new biological nano-selenium fermentation broth\nbased on Bacillus subtilis SE201412","volume":"13","author":"Huang","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"2026081910144584100_cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2024.102303","article-title":"Industrial-level\nproduction of ultrastable selenium nanoparticles using a confined\ncoordination synthetic strategy","volume":"5","author":"He","year":"2024","journal-title":"Cell Rep. Phys.\nSci."},{"issue":"21","key":"2026081910144584100_cit99","doi-asserted-by":"publisher","DOI":"10.3390\/nu16213659","article-title":"Legal Standards\nfor Selenium Enriched Foods and Agricultural Products: Domestic and\nInternational Perspectives","volume":"16","author":"Ren","year":"2024","journal-title":"Nutrients"},{"issue":"19","key":"2026081910144584100_cit100","doi-asserted-by":"publisher","DOI":"10.3390\/nu15194189","article-title":"Research Progress of Selenium-Enriched Foods","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"issue":"10","key":"2026081910144584100_cit101","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.2174\/1871530320666200519084415","article-title":"Nutraceuticals: A Comparative\nAnalysis\nof Regulatory Framework in Different Countries of the World","volume":"20","author":"Bansal","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"issue":"8","key":"2026081910144584100_cit102","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2021.6769","article-title":"Guidance on\ntechnical requirements for regulated food and feed product applications\nto establish the presence of small particles including nanoparticles","volume":"19","author":"More","year":"2021","journal-title":"EFSA J."},{"key":"2026081910144584100_cit103","volume-title":"Technical Specification\nfor the Use of Bio-Nano Selenium in Livestock","author":"Association, Guangxi Agriculture and Rural Industry Revitalization Promotion.","year":"2026"}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c04376","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/32\/24781\/66418093\/acs.jafc.6c04376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/32\/24781\/66418093\/acs.jafc.6c04376.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:14:53Z","timestamp":1787148893000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/32\/24781\/5246477\/Probiotics-Derived-Selenium-Nanoparticles-A-Novel"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":103,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,8,5]]},"published-print":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c04376","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]}}}