{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:04:20Z","timestamp":1793019860798,"version":"4.5.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030103"],"award-info":[{"award-number":["32030103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32570592"],"award-info":[{"award-number":["32570592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2024TIAD-KPX0026"],"award-info":[{"award-number":["CSTB2024TIAD-KPX0026"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1201600"],"award-info":[{"award-number":["2022YFD1201600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gut microbial imbalance is a constraint on insect health and artificial diet-based silkworm rearing, but how lepidopteran hosts convert microbial fluctuations into appropriate immune output remains unclear. In this study, we investigated the molecular mechanism by which the microbiota-responsive factor BmMBF2\u201311 regulates gut immune homeostasis in Bombyx mori. Transcriptomic and interactomic analyses, together with structural prediction, colocalization, Co-IP, BiFC, and GST pull-down assays, identified FADD as a direct interacting partner of BmMBF2\u201311. Bacterial challenge with Staphylococcus sciuri or Enterococcus mundtii showed that BmMBF2\u201311 was associated with the induction of FADD, Relish, and multiple antimicrobial peptide genes, whereas FADD knockdown impaired these transcriptional responses. FADD knockdown increased bacterial load, reduced microbial diversity, remodeled gut microbial composition, weakened E. mundtii clearance, and reduced host survival. These findings reveal a BmMBF2\u201311\u2013FADD regulatory axis linking IMD\/Relish-related immune output to gut microbial homeostasis and provide insight into silkworm health management under artificial diet-rearing conditions.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04482","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:02:44Z","timestamp":1786482164000},"page":"26256-26273","source":"Crossref","is-referenced-by-count":1,"title":["BmMBF2\u201311\nCouples FADD-Mediated IMD Signaling\nto Gut Microbial Homeostasis in the Silkworm"],"prefix":"10.1021","volume":"74","author":[{"given":"Qingxiu","family":"He","sequence":"first","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Liu","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-2886","authenticated-orcid":true,"given":"Qingyou","family":"Xia","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-0472","authenticated-orcid":true,"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"5","key":"2026090104483689500_cit1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/1574-6976.12025","article-title":"The gut microbiota of insects - diversity in structure\nand function","volume":"37","author":"Engel","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"2026090104483689500_cit2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev-ento-010814-020822","article-title":"Multiorganismal\ninsects: diversity and function of resident microorganisms","volume":"60","author":"Douglas","year":"2015","journal-title":"Annu. Rev. Entomol."},{"key":"2026090104483689500_cit3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cois.2020.06.004","article-title":"Impact of the insect\ngut microbiota on ecology, evolution,\nand industry","volume":"41","author":"Jang","year":"2020","journal-title":"Curr. Opin. Insect Sci."},{"issue":"3","key":"2026090104483689500_cit4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/mec.16285","article-title":"Host species\nidentity shapes the diversity and structure of insect microbiota","volume":"31","author":"Malacrino","year":"2022","journal-title":"Mol. Ecol."},{"issue":"1","key":"2026090104483689500_cit5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41522-023-00435-y","article-title":"The pivotal roles of gut microbiota\nin insect plant interactions for sustainable pest management","volume":"9","author":"Zhang","year":"2023","journal-title":"Npj Biofilms Microbiomes"},{"issue":"3","key":"2026090104483689500_cit6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2001861","article-title":"Antibiotic exposure perturbs the\ngut microbiota and elevates mortality in honeybees","volume":"15","author":"Raymann","year":"2017","journal-title":"PLoS Biol."},{"issue":"41","key":"2026090104483689500_cit7","doi-asserted-by":"publisher","first-page":"10305","DOI":"10.1073\/pnas.1803880115","article-title":"Glyphosate\nperturbs the gut microbiota\nof honey bees","volume":"115","author":"Motta","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S.\nA."},{"issue":"9","key":"2026090104483689500_cit8","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1038\/s41396-018-0174-1","article-title":"Gut bacterial\nand fungal communities of the domesticated silkworm (Bombyx mori)\nand wild mulberry-feeding relatives","volume":"12","author":"Chen","year":"2018","journal-title":"ISME J."},{"issue":"46","key":"2026090104483689500_cit9","doi-asserted-by":"publisher","first-page":"26188","DOI":"10.1039\/C8RA04627A","article-title":"Differences\nin gut microbiota between silkworms (Bombyx mori) reared\non fresh mulberry (Morus alba var. multicaulis) leaves or an artificial\ndiet","volume":"8","author":"Dong","year":"2018","journal-title":"RSC Adv."},{"issue":"6","key":"2026090104483689500_cit10","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02357-22","article-title":"Effects of Microbial Transfer during\nFood-Gut-Feces Circulation on the Health of Bombyx mori","volume":"10","author":"Qin","year":"2022","journal-title":"Microbiol. Spectrum."},{"issue":"12","key":"2026090104483689500_cit11","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3390\/insects15120970","article-title":"Dynamic Alterations\nof the Intestinal Microbiota of Fifth-Instar\nSilkworms (Bombyx mori) Fed an Artificial Diet or Mulberry Leaves","volume":"15","author":"Chen","year":"2024","journal-title":"Insects"},{"issue":"3","key":"2026090104483689500_cit12","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.3390\/ijms25031722","article-title":"Effects of Habitual\nDietary Change on the Gut Microbiota and Health\nof Silkworms","volume":"25","author":"Wang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"2026090104483689500_cit13","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3390\/ani14091261","article-title":"Gut Microbiota Analysis in Silkworms (Bombyx mori) Provides Insights\ninto Identifying Key Bacterials for Inclusion in Artificial Diet Formulations","volume":"14","author":"Xin","year":"2024","journal-title":"Animals"},{"issue":"16","key":"2026090104483689500_cit14","doi-asserted-by":"publisher","first-page":"12731","DOI":"10.3390\/ijms241612731","article-title":"Homeostatic Regulation of the Duox-ROS Defense System:\nRevelations Based on the Diversity of Gut Bacteria in Silkworms (Bombyx\nmori)","volume":"24","author":"Shu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"2026090104483689500_cit15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.chom.2012.06.002","article-title":"Peptidoglycan sensing by the receptor\nPGRP-LE in the Drosophila gut induces immune responses to infectious\nbacteria and tolerance to microbiota","volume":"12","author":"Bosco-Drayon","year":"2012","journal-title":"Cell Host\nMicrobe"},{"issue":"4","key":"2026090104483689500_cit16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/embo-reports\/kvd073","article-title":"The Drosophila\ncaspase Dredd is required to resist gram-negative bacterial infection","volume":"1","author":"Leulier","year":"2000","journal-title":"EMBO Rep."},{"issue":"5","key":"2026090104483689500_cit17","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S1074-7613(02)00454-5","article-title":"The Drosophila\nimmune defense against gram-negative infection requires the death\nprotein dFADD","volume":"17","author":"Naitza","year":"2002","journal-title":"Immunity"},{"issue":"4","key":"2026090104483689500_cit18","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1073\/pnas.0404952102","article-title":"Drosophila\npeptidoglycan recognition protein LC (PGRP-LC)\nacts as a signal-transducing innate immune receptor","volume":"102","author":"Choe","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"2026090104483689500_cit19","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00824-21","article-title":"Drosophila\nAntimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition\nand Abundance","volume":"12","author":"Marra","year":"2021","journal-title":"mBio"},{"issue":"1","key":"2026090104483689500_cit20","doi-asserted-by":"publisher","first-page":"2208503","DOI":"10.1080\/19490976.2023.2208503","article-title":"The role of Drosophila microbiota\nin gut homeostasis\nand immunity","volume":"15","author":"Tafesh-Edwards","year":"2023","journal-title":"Gut Microbes"},{"key":"2026090104483689500_cit21","doi-asserted-by":"publisher","DOI":"10.1111\/1744-7917.70178","article-title":"Peptidoglycan recognition protein L1 regulates intestinal\nimmunity\nand microbial homeostasis via the IMD pathway in the silkworm, Bombyx\nmori","author":"Liu","year":"2025","journal-title":"Insect Sci."},{"issue":"5","key":"2026090104483689500_cit22","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1128\/mcb.14.5.3013-3021.1994","article-title":"Mediators of activation of fushi\ntarazu gene transcription by BmFTZ-F1","volume":"14","author":"Li","year":"1994","journal-title":"Mol.\nCell. Biol."},{"issue":"2","key":"2026090104483689500_cit23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1046\/j.1365-2443.1997.1090306.x","article-title":"Transcriptional\nactivation through interaction of MBF2\nwith TFIIA","volume":"2","author":"Li","year":"1997","journal-title":"Genes Cells"},{"issue":"2","key":"2026090104483689500_cit24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1006\/dbio.2000.9836","article-title":"MBF2 is a\ntissue- and stage-specific\ncoactivator that Is regulated at the step of nuclear transport in\nthe silkworm Bombyx mori","volume":"225","author":"Liu","year":"2000","journal-title":"Dev. Biol."},{"issue":"4","key":"2026090104483689500_cit25","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/1744-7917.12349","article-title":"Identification\nof MBF2 family genes in Bombyx mori and their expression in different\ntissues and stages and in response to Bacillus bombysepticus infection\nand starvation","volume":"23","author":"Zhou","year":"2016","journal-title":"Insect Sci."},{"issue":"4","key":"2026090104483689500_cit26","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/imb.12566","article-title":"Specific\ngenes related to nucleopolyhedrovirus in Bombyx mori susceptible\nand near-isogenic resistant strains through comparative transcriptome\nanalysis","volume":"28","author":"Chen","year":"2019","journal-title":"Insect Mol. Biol."},{"key":"2026090104483689500_cit27","doi-asserted-by":"publisher","first-page":"104516","DOI":"10.1016\/j.ibmb.2026.104516","article-title":"Microbiota-responsive BmMBF2\u201311 limits dysbiosis\nand promotes\nintestinal immune homeostasis in the silkworm","volume":"190","author":"He","year":"2026","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2026090104483689500_cit28","doi-asserted-by":"publisher","first-page":"117866","DOI":"10.1016\/j.envpol.2021.117866","article-title":"Imbalance of intestinal\nmicrobial homeostasis caused by acetamiprid\nis detrimental to resistance to pathogenic bacteria in Bombyx mori","volume":"289","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"issue":"3","key":"2026090104483689500_cit29","doi-asserted-by":"publisher","first-page":"111523","DOI":"10.1016\/j.celrep.2022.111523","article-title":"Compartmentalized PGRP\nexpression along the dipteran Bactrocera dorsalis gut forms a zone\nof protection for symbiotic bacteria","volume":"41","author":"Yao","year":"2022","journal-title":"Cell Rep."},{"key":"2026090104483689500_cit30","doi-asserted-by":"publisher","first-page":"1154811","DOI":"10.3389\/fmicb.2023.1154811","article-title":"Effects of\ninsecticidal proteins of Enterobacter cloacae NK on cellular immunity\nof Galleria mellonella larvae","volume":"14","author":"Liao","year":"2023","journal-title":"Front. Microbiol."},{"issue":"1","key":"2026090104483689500_cit31","doi-asserted-by":"publisher","first-page":"wrae051","DOI":"10.1093\/ismejo\/wrae051","article-title":"Chronic bee paralysis virus exploits\nhost antimicrobial peptides\nand alters gut microbiota composition to facilitate viral infection","volume":"18","author":"Deng","year":"2024","journal-title":"ISME J."},{"issue":"5973","key":"2026090104483689500_cit32","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1126\/science.1184008","article-title":"A peroxidase\/dual\noxidase system modulates midgut epithelial\nimmunity in Anopheles gambiae","volume":"327","author":"Kumar","year":"2010","journal-title":"Science"},{"issue":"2","key":"2026090104483689500_cit33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0167-7012(00)00241-4","article-title":"How to optimize the drop plate method\nfor enumerating bacteria","volume":"44","author":"Herigstad","year":"2001","journal-title":"J. Microbiol Methods"},{"issue":"21","key":"2026090104483689500_cit34","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve\ngenome assemblies","volume":"27","author":"Magoc","year":"2011","journal-title":"Bioinformatics"},{"issue":"17","key":"2026090104483689500_cit35","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast\nall-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"5","key":"2026090104483689500_cit36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis\nof high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"issue":"7","key":"2026090104483689500_cit37","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina\namplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"issue":"8","key":"2026090104483689500_cit38","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible\nmicrobiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat.\nBiotechnol."},{"issue":"7","key":"2026090104483689500_cit39","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database\nand workbench compatible with ARB","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl. Environ.\nMicrobiol."},{"key":"2026090104483689500_cit40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-4939-8728-3_8","article-title":"16S rRNA Gene Analysis with QIIME2","volume":"1849","author":"Hall","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"23","key":"2026090104483689500_cit41","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing\nmothur: open-source, platform-independent,\ncommunity-supported software for describing and comparing microbial\ncommunities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"2026090104483689500_cit42","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an\ninteractive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinf."},{"issue":"6","key":"2026090104483689500_cit43","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic\nbiomarker discovery and\nexplanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"2026090104483689500_cit44","doi-asserted-by":"publisher","first-page":"103225","DOI":"10.1016\/j.ibmb.2019.103225","article-title":"A tandem death effector domain-containing protein inhibits the IMD\nsignaling pathway via forming amyloid-like aggregates with the caspase-8\nhomolog DREDD","volume":"114","author":"Hu","year":"2019","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"20","key":"2026090104483689500_cit45","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.1111\/febs.17028","article-title":"Ubiquitin signalling in Drosophila\ninnate immune responses","volume":"291","author":"Aalto","year":"2024","journal-title":"FEBS J."},{"issue":"12","key":"2026090104483689500_cit46","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/S0960-9822(02)00873-4","article-title":"Inducible\nexpression of double-stranded RNA reveals a role for dFADD in the\nregulation of the antibacterial response in Drosophila adults","volume":"12","author":"Leulier","year":"2002","journal-title":"Curr. Biol."},{"issue":"12","key":"2026090104483689500_cit47","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1038\/emboj.2012.121","article-title":"Ubiquitylation of the initiator caspase DREDD\nis required for innate immune signalling","volume":"31","author":"Meinander","year":"2012","journal-title":"EMBO\nJ."},{"issue":"24","key":"2026090104483689500_cit48","doi-asserted-by":"publisher","first-page":"9779","DOI":"10.1073\/pnas.0812022106","article-title":"Two roles for the Drosophila IKK complex in the activation\nof Relish and the induction of antimicrobial peptide genes","volume":"106","author":"Erturk-Hasdemir","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"2026090104483689500_cit49","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.4049\/jimmunol.1303309","article-title":"The Drosophila\nimd signaling pathway","volume":"192","author":"Myllymaki","year":"2014","journal-title":"J. Immunol."},{"issue":"1","key":"2026090104483689500_cit50","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.dci.2013.05.014","article-title":"The Drosophila IMD pathway in the activation of the\nhumoral immune response","volume":"42","author":"Kleino","year":"2014","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"2026090104483689500_cit51","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.immuni.2011.09.018","article-title":"Negative regulation\nby amidase PGRPs shapes the Drosophila antibacterial response and\nprotects the fly from innocuous infection","volume":"35","author":"Paredes","year":"2011","journal-title":"Immunity"},{"issue":"4","key":"2026090104483689500_cit52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008458","article-title":"Hyd ubiquitinates the NF-kappaB co-factor Akirin to operate an effective\nimmune response in Drosophila","volume":"16","author":"Cammarata-Mouchtouris","year":"2020","journal-title":"PLoS Pathog"},{"issue":"8","key":"2026090104483689500_cit53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009718","article-title":"Drosophila H2Av negatively regulates\nthe activity of the IMD pathway\nvia facilitating Relish SUMOylation","volume":"17","author":"Tang","year":"2021","journal-title":"PLoS Genet."},{"issue":"3","key":"2026090104483689500_cit54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010356","article-title":"SUMOylation of Jun fine-tunes the\nDrosophila gut immune\nresponse","volume":"18","author":"Soory","year":"2022","journal-title":"PLoS Pathog"},{"key":"2026090104483689500_cit55","doi-asserted-by":"publisher","first-page":"17056","DOI":"10.1038\/nmicrobiol.2017.56","article-title":"Bap180\/Baf180\nis required to maintain homeostasis of intestinal innate immune response\nin Drosophila and mice","volume":"2","author":"He","year":"2017","journal-title":"Nat. Microbiol."},{"issue":"3","key":"2026090104483689500_cit56","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.chom.2018.01.011","article-title":"Inflammation-Modulated Metabolic Reprogramming\nIs Required for DUOX-Dependent Gut Immunity in Drosophila","volume":"23","author":"Lee","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"8","key":"2026090104483689500_cit57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008989","article-title":"Drosophila\nMyc restores immune homeostasis of Imd pathway via activating miR-277\nto inhibit imd\/Tab2","volume":"16","author":"Li","year":"2020","journal-title":"PLoS Genet."},{"issue":"10","key":"2026090104483689500_cit58","doi-asserted-by":"publisher","first-page":"107736","DOI":"10.1016\/j.celrep.2020.107736","article-title":"Dietary Adaptation\nof Microbiota\nin Drosophila Requires NF-kappaB-Dependent Control of the Translational\nRegulator 4E-BP","volume":"31","author":"Vandehoef","year":"2020","journal-title":"Cell Rep."},{"issue":"5864","key":"2026090104483689500_cit59","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.1149357","article-title":"Innate immune homeostasis\nby the homeobox gene caudal\nand commensal-gut mutualism in Drosophila","volume":"319","author":"Ryu","year":"2008","journal-title":"Science"},{"issue":"1","key":"2026090104483689500_cit60","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40168-020-00823-y","article-title":"Most dominant roles of insect gut\nbacteria: digestion, detoxification, or essential nutrient provision?","volume":"8","author":"Jing","year":"2020","journal-title":"Microbiome"},{"issue":"4","key":"2026090104483689500_cit61","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1007\/s00248-022-02014-8","article-title":"Effect of Chronic Exposure\nto Sublethal Doses of Imidacloprid and Nosema ceranae on Immunity,\nGut Microbiota, and Survival of Africanized Honey Bees","volume":"85","author":"Balbuena","year":"2023","journal-title":"Microb. Ecol."},{"key":"2026090104483689500_cit62","doi-asserted-by":"publisher","first-page":"905899","DOI":"10.3389\/fimmu.2022.905899","article-title":"Drosophila\nRelish Activating lncRNA-CR33942 Transcription Facilitates Antimicrobial\nPeptide Expression in Imd Innate Immune Response","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c04482","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/33\/26256\/66503392\/acs.jafc.6c04482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/33\/26256\/66503392\/acs.jafc.6c04482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:48:43Z","timestamp":1788252523000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/33\/26256\/5252981\/BmMBF2-11-Couples-FADD-Mediated-IMD-Signaling-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":62,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,11]]},"published-print":{"date-parts":[[2026,8,26]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c04482","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]}}}