{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:18:20Z","timestamp":1788254300205,"version":"build-2803163510"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"Scientific and Technological Frontiers in Project of Henan Province","doi-asserted-by":"publisher","award":["252102111099"],"award-info":[{"award-number":["252102111099"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As part of an ongoing effort to develop novel succinate dehydrogenase inhibitors (SDHIs), a range of innovative nicotinamide derivatives featuring stilbene scaffolds were synthesized and assessed for their antifungal properties. Lead compounds 6g and 6c demonstrated significant antifungal efficacies against Rhizoctonia solani and Sclerotinia sclerotiorum, with EC50 (half maximal effective concentration) values of 0.008 and 0.034 \u03bcg\/mL, respectively, surpassing Boscalid (EC50 = 0.573 and 0.455 \u03bcg\/mL, respectively) and Fluxapyroxad (EC50 = 0.026 and 0.037 \u03bcg\/mL, respectively). Detached leaf assays further confirmed their excellent protective and curative effects, outperforming Boscalid and Fluxapyroxad. Further studies revealed that compound 6g operated through a mechanism akin to Boscalid and Fluxapyroxad. These results indicated that both 6g and 6c showed great potential as novel SDHIs for effectively managing R. solani and S. sclerotiorum, underscoring the necessity for further research to fully explore their capabilities.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04703","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:02:33Z","timestamp":1786726953000},"page":"25976-25989","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Novel\nStilbene-Containing Nicotinamide\nDerivatives as Potential SDHIs against\n                    <i>Rhizoctonia solani<\/i>\n                    and\n                    <i>Sclerotinia sclerotiorum<\/i>"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-4446","authenticated-orcid":true,"given":"Bo","family":"Luo","sequence":"first","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Hu","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]},{"name":"Dabie Mountain Laboratory , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Tao","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinge","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Hu","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Wu","sequence":"additional","affiliation":[{"name":"Xinyang Normal University , , , ,","place":["Xinyang, Henan, China, 464000"]},{"name":"Dabie Mountain Laboratory , , ,","place":["Xinyang, Henan, China, 464000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"2026090104484088200_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.106162","article-title":"Baseline sensitivity and resistance risk of Sclerotinia sclerotiorum to glabridin and the possible\nanti-fungal mechanism","volume":"205","author":"Xu","year":"2024","journal-title":"Pestic. 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