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Herein, we report a single-atom-switching strategy for constructing a six-member, full-spectrum library of ClO\u2013-responsive probes. Aqueous screening identified Scou, Scou-Ph, and Scou-CN as selected candidates based on pronounced spectral responses and visual contrast. HRMS supports the ClO\u2013-triggered oxidative desulfurization of the thiocarbonyl moiety to the corresponding carbonyl fluorophore, while DFT calculations rationalize the associated spectral changes. Detailed evaluation of the three probes revealed distinguishable fluorescence responses over pH 2\u201310 and enabled determination of ClO\u2013 in tap water and lake water, affording recoveries of 98.3\u2013111% with RSD values of 0.22\u20136.1%. This work expands the structural diversity of ClO\u2013 probes and offers a practical workflow for molecular-library screening and selected-probe evaluation.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04724","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:01:59Z","timestamp":1788523319000},"page":"28831-28839","source":"Crossref","is-referenced-by-count":0,"title":["Single-Atom Switching\nfor Constructing a Full-Spectrum\nHypochlorite-Responsive Probe Library: Screening Candidates for Water\nAnalysis"],"prefix":"10.1021","volume":"74","author":[{"given":"Hua-Feng","family":"Mao","sequence":"first","affiliation":[{"name":"Xihua University , , ,","place":["Chengdu, China, 610039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5950-0042","authenticated-orcid":true,"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Xihua University , , ,","place":["Chengdu, China, 610039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xiang","family":"Lan","sequence":"additional","affiliation":[{"name":"Xihua University , , ,","place":["Chengdu, China, 610039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-2585","authenticated-orcid":true,"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Xihua University , , ,","place":["Chengdu, China, 610039"]},{"name":"Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province , ,","place":["Chengdu, China, 610039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Xihua University , , ,","place":["Chengdu, China, 610039"]},{"name":"Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province , ,","place":["Chengdu, China, 610039"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8383-2591","authenticated-orcid":true,"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education of Sichuan , ,","place":["Zigong, China, 643000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Xihua University , , ,","place":["Chengdu, China, 610039"]},{"name":"Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province , ,","place":["Chengdu, China, 610039"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"2026091609094960500_cit1","doi-asserted-by":"publisher","first-page":"107922","DOI":"10.1016\/j.cclet.2022.107922","article-title":"The water-soluble\nbicyclic 2-pyridone-based fluorescent probe for fast and selective\ndetection of hypochlorite","volume":"34","author":"Zhou","year":"2023","journal-title":"Chin. 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