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Sparassis latifolia polysaccharides (SLPs) may regulate microbiota\u2013host metabolic interactions. Here, we evaluated the hypoglycemic effects of SLPs in mice with high-fat\/high-sugar diet and streptozotocin-induced glucose metabolism disorders. SLPs improved glucose tolerance, reduced fasting blood glucose by approximately 40%, alleviated colonic injury, and restored gut microbiota-derived short-chain fatty acids (SCFAs). Metabolomics showed that SLPs mainly normalized purine metabolism, primary bile acid biosynthesis, and vitamin B6 metabolism. SLP treatment also modulated intestinal gluconeogenesis-related genes, proteins, and enzymes, Microbiota and coabundance group analyses indicated increased beneficial taxa, including Muribaculaceae and Bacteroides acidifaciens, and reduced CAG6 and CAG8 (Co-abundance group) taxa associated with impaired glucose tolerance. Cohabitation experiments suggested partial transmissibility of metabolic benefits. These findings suggest that SLPs improve glucose metabolism by remodeling gut microbiota and metabolites and enhancing PXR-SGK2-associated intestinal gluconeogenesis.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04853","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:25:06Z","timestamp":1784769906000},"page":"23522-23542","source":"Crossref","is-referenced-by-count":2,"title":["Gut Microbiota\nReshaping by\n                    <i>Sparassis latifolia<\/i>\n                    Polysaccharides Ameliorates Glucose Metabolism\nthrough Microbiota-Mediated Activation of Intestinal Gluconeogenesis"],"prefix":"10.1021","volume":"74","author":[{"given":"Xin","family":"Wei","sequence":"first","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaman","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Jin","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Rong","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]},{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-9753","authenticated-orcid":true,"given":"Shaojun","family":"Yun","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]},{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feier","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]},{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]},{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9133-6081","authenticated-orcid":true,"given":"Cuiping","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]},{"name":"Shanxi Agricultural University , , , ,","place":["Taigu, Shanxi, China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2026080510083321500_cit1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s42255-025-01226-9","article-title":"A short-term, high-caloric diet has prolonged effects\non brain insulin action in men","volume":"7","author":"Kullmann","year":"2025","journal-title":"Nat. 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Macromol."},{"key":"2026080510083321500_cit22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.17113\/ftb.60.04.22.7561","article-title":"The effects\nof a high-fat\/cholesterol\ndiet on the intestine of rats were attenuated by Sparassis latifolia\npolysaccharides","volume":"60","author":"Wei","year":"2022","journal-title":"Food Technol. Biotechnol."},{"key":"2026080510083321500_cit23","unstructured":"He, L.\n          \n          The regulatory\neffect of Sparassis latifolia polysaccharides on skeletal muscle glucose\nmetabolism in high-fat mice and the influence of iron modification\non its inhibitory action on \u03b1-glucosidase activity, Thesis, Shanxi Agricultural University, 2023."},{"key":"2026080510083321500_cit24","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1080\/10942912.2018.1510838","article-title":"Rheological properties\nand gel characteristics of polysaccharides\nfrom fruit-bodies of Sparassis crispa","volume":"21","author":"Hao","year":"2018","journal-title":"Int.\nJ. Food Prop."},{"key":"2026080510083321500_cit25","first-page":"46","article-title":"Structural\ncharacterization and immunomodulatory activities of a single-component\npolysaccharide from the fruiting body of Sparassis crispa","volume":"21","author":"Hao","year":"2021","journal-title":"J. Chin. Inst. Food Sci. 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