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Virtual screening predicted potential interactions of KTFQGPPHG with Ca2+ and calcium transport-related proteins, including TRPV6, Cav1.3, and PepT1. During simulated digestion, KTFQGPPHG-Ca showed high intestinal-phase stability, with a calcium retention rate of 94.13 \u00b1 1.47%, while its major digestive fragment, TFQGPPHG, retained substantial calcium-binding activity. In Caco-2 cell monolayers, both KTFQGPPHG-Ca and TFQGPPHG-Ca significantly enhanced calcium transport compared with CaCl2, with Cav1.3 and TRPV6 being major pathways involved in this process. Proteomic analysis suggested that these chelates may regulate calcium absorption-associated epithelial pathways, including \u201ccell adhesion molecules\u201d and \u201cECM\u2013receptor interaction,\u201d which may contribute to epithelial barrier integrity and cell-matrix signaling associated with Ca2+ transport. In conclusion, KTFQGPPHG-Ca exhibits high gastrointestinal stability and enhances calcium transport through multiple pathways, supporting its potential development as a novel calcium supplement.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c04863","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:01:46Z","timestamp":1787230906000},"page":"27268-27285","source":"Crossref","is-referenced-by-count":1,"title":["<i>Moringa oleifera<\/i>\n                    Lam.\nLeaf Peptide-Calcium Chelate (KTFQGPPHG-Ca): Screening,\n                    <i>In Vitro<\/i>\n                    Digestive Stability, Cellular Transport, and Potential\nCalcium Absorption Mechanisms"],"prefix":"10.1021","volume":"74","author":[{"given":"Zilin","family":"Wang","sequence":"first","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijing","family":"Gu","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimin","family":"Xie","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1013-390X","authenticated-orcid":true,"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]},{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]},{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Zhanjiang, Guangdong, China, 524023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-5266","authenticated-orcid":true,"given":"Liang","family":"Tao","sequence":"additional","affiliation":[{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]},{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]},{"name":"Yunnan Agricultural University , , , ,","place":["Kunming, Yunnan, China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"13","key":"2026090311501380200_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17132073","article-title":"Influence of Dietary\nCalcium Intake on Skeletal Health and Body Composition in an Italian\nElderly Population","volume":"17","author":"Caffarelli","year":"2025","journal-title":"Nutrients"},{"issue":"1","key":"2026090311501380200_cit2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/nyas.14758","article-title":"Calcium deficiency\nworldwide: prevalence of inadequate intakes and associated health\noutcomes","volume":"1512","author":"Shlisky","year":"2022","journal-title":"Ann. 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