{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:51:18Z","timestamp":1792648278604,"version":"4.5.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"crossref","award":["PA2025GDSK0067"],"award-info":[{"award-number":["PA2025GDSK0067"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["22422604"],"award-info":[{"award-number":["22422604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Analytical array detection holds great promise for multipesticide residue analysis, yet faces key challenges such as cross-channel material interference and error accumulation. Herein, we report a multifunctional \u201call-in-one\u201d Cu@Zr-MOF nanozyme with intrinsic fluorescence (FL), phosphatase-like (OPH), laccase-like (LAC), and peroxidase-like (POD) activities, which are integrated into a response array for the distinguishing six pesticides ranging from 1.0 to 225.0 ppm via machine learning (ML) technology. This array enables high-throughput discrimination of six pesticides via unsupervised methods. Furtherore, an intelligent stepwise machine-learning approach integrating support vector machine classification and support vector regression achieves both qualitative and quantitative analysis. The entire multichannel analysis is efficient, requiring just 40.0 min to operate (15.0 min for sample-nanozyme preincubation and 25.0 min for signal output). Crucially, the proposed response array enables pesticide detection in six foods with satisfactory recoveries and dynamic monitoring on tomatoes with good accuracy, advancing single-material arrays for food safety monitoring.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05019","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:23:37Z","timestamp":1785849817000},"page":"25705-25716","source":"Crossref","is-referenced-by-count":1,"title":["AI-Decoded Multicatalytic\nActivities Nanozyme Platform:\nIntegrated Identification and Quantification of Multiplexed Pesticide\nResidues"],"prefix":"10.1021","volume":"74","author":[{"given":"Si","family":"Li","sequence":"first","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linpin","family":"Luo","sequence":"additional","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-7371","authenticated-orcid":true,"given":"Kai","family":"Guo","sequence":"additional","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjiao","family":"He","sequence":"additional","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-2732","authenticated-orcid":true,"given":"Zhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongning","family":"Wu","sequence":"additional","affiliation":[{"name":"China National Center for Food Safety Risk Assessment (CFSA) , , ,","place":["Beijing, China, 100022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4463-3729","authenticated-orcid":true,"given":"Yizhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Hefei University of Technology , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081910160665700_cit1","doi-asserted-by":"publisher","first-page":"101163","DOI":"10.1016\/j.oneear.2024.11.017","article-title":"Mitigating pesticide mixture hazard\nin global surface waters through agricultural management","volume":"8","author":"Chen","year":"2025","journal-title":"One Earth"},{"key":"2026081910160665700_cit2","doi-asserted-by":"publisher","first-page":"101491","DOI":"10.1016\/j.oneear.2025.101491","article-title":"Safe and\nsustainable croplands","volume":"8","author":"Winowiecki","year":"2025","journal-title":"One Earth"},{"key":"2026081910160665700_cit3","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.1021\/acs.analchem.2c05198","article-title":"Direct and specific\ndetection of glyphosate using a phosphatase-like nanozyme-mediated\nchemiluminescence strategy","volume":"95","author":"Chang","year":"2023","journal-title":"Anal. Chem."},{"key":"2026081910160665700_cit4","doi-asserted-by":"publisher","first-page":"104340","DOI":"10.1016\/j.tifs.2024.104340","article-title":"A review of cumulative\nrisk assessment of multiple pesticide residues\nin food: Current status, approaches and future perspectives","volume":"144","author":"Yang","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"2026081910160665700_cit5","doi-asserted-by":"publisher","first-page":"100781","DOI":"10.1016\/j.xinn.2024.100781","article-title":"Self-calibrating\nmultiplexed microneedle electrode array for continuous mapping of\nsubcutaneous multi-analytes in diabetes","volume":"6","author":"Li","year":"2025","journal-title":"Innovation"},{"key":"2026081910160665700_cit6","doi-asserted-by":"publisher","first-page":"33452","DOI":"10.1021\/acsnano.4c10203","article-title":"A universal\nmethod for fingerprinting multiplexed bacteria:\nevolving pruned sensor arrays via machine learning-driven combinatorial\ngroup-specificity strategy","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"key":"2026081910160665700_cit7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41467-023-36024-y","article-title":"Differential\nsensing with arrays of de novo\ndesigned peptide assemblies","volume":"14","author":"Dawson","year":"2023","journal-title":"Nat. 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Lett."},{"key":"2026081910160665700_cit28","doi-asserted-by":"publisher","first-page":"119277","DOI":"10.1016\/j.jece.2025.119277","article-title":"Efficient\nadsorption and sensitive\ndetection of tetracycline antibiotics based on pyrene-functionalized\nCu-MOF","volume":"13","author":"Wu","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"2026081910160665700_cit29","doi-asserted-by":"publisher","first-page":"6347","DOI":"10.1021\/acs.analchem.5c00745","article-title":"Electrochemical\nsensing of perfluorooctanoic acid via a rationally designed fluorine-functionalized\nCu-MOF and in-depth analysis of sensing mechanism","volume":"97","author":"Zheng","year":"2025","journal-title":"Anal. 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J."},{"key":"2026081910160665700_cit32","doi-asserted-by":"publisher","first-page":"118451","DOI":"10.1016\/j.jece.2025.118451","article-title":"Regulation\nmechanism of ligand engineering on the adsorption performance of bimetallic\nNi\/Co-MOF-carboxymethylcellulose composite towards Cu2+","volume":"13","author":"Kong","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"2026081910160665700_cit33","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.ijhydene.2024.02.366","article-title":"A comprehensive\nstudy on the kinetics and isotherms of D2\/H2 adsorptive separation\nusing pure and composite Cu-BDC-NH2 MOFs at 77 K","volume":"61","author":"Dastbaz","year":"2024","journal-title":"Int. J. Hydrogen Energy"},{"key":"2026081910160665700_cit34","doi-asserted-by":"publisher","first-page":"122868","DOI":"10.1016\/j.seppur.2022.122868","article-title":"Bimetallic metal-organic\nframeworks for efficient visible-light-driven\nphotocatalytic CO2 reduction and H2 generation","volume":"308","author":"Ezugwu","year":"2023","journal-title":"Sep. Purif. Technol."},{"key":"2026081910160665700_cit35","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.1021\/acs.analchem.1c02949","article-title":"Design and\nmultiple applications of mixed-ligand metal\u2013organic frameworks\nwith dual emission","volume":"94","author":"Yin","year":"2022","journal-title":"Anal. 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Interfaces"},{"key":"2026081910160665700_cit39","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1021\/acssensors.9b00237","article-title":"An Exonuclease I-Assisted\nSilver-Metallized Electrochemical Aptasensor for Ochratoxin A Detection","volume":"4","author":"Suea-N","year":"2019","journal-title":"ACS Sens."},{"key":"2026081910160665700_cit40","doi-asserted-by":"publisher","first-page":"4842","DOI":"10.1021\/acs.est.0c07722","article-title":"Foliar photodegradation\nin pesticide fate modeling:\ndevelopment and evaluation of the pesticide dissipation from agricultural\nland (PeDAL) model","volume":"55","author":"Lyons","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"2026081910160665700_cit41","doi-asserted-by":"publisher","first-page":"129177","DOI":"10.1016\/j.jhazmat.2022.129177","article-title":"Predicting pesticide dissipation\nhalf-life intervals in plants with\nmachine learning models","volume":"436","author":"Shen","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"2026081910160665700_cit42","doi-asserted-by":"publisher","first-page":"137428","DOI":"10.1016\/j.jhazmat.2025.137428","article-title":"Dissipation\nof the insecticide profenofos\nin tropical agricultural soils (Berambadi catchment, South India):\nInsight from compound-specific isotope analysis (CSIA)","volume":"488","author":"Masbou","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"2026081910160665700_cit43","doi-asserted-by":"publisher","first-page":"119794","DOI":"10.1016\/j.envpol.2022.119794","article-title":"Field leaching study - Inverse estimation\nof degradation and sorption parameters for a mobile soil metabolite\nand its pesticide parent","volume":"310","author":"Sur","year":"2022","journal-title":"Environ. 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