{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:06:35Z","timestamp":1789671995174,"version":"4.0.1"},"reference-count":202,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472170"],"award-info":[{"award-number":["82472170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application","award":["SS2018003"],"award-info":[{"award-number":["SS2018003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 2 diabetes mellitus (T2DM) is increasingly viewed as a systemic metabolic disorder rather than as an isolated glycemic defect. It is closely linked to obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), sharing mechanisms such as insulin resistance, chronic inflammation, and interorgan crosstalk among the gut, liver, adipose tissue, pancreas, and central nervous system. Plant-derived nanovesicles (PDNVs) are emerging cross-kingdom nanoplatforms with the potential to modulate metabolic and inflammatory signaling. Evidence from T2DM, obesity, and MASLD models suggests that PDNVs can improve metabolic homeostasis by reprogramming metabolism and reducing inflammation. PDNVs may modulate organ axes, particularly gut\u2013liver and gut\u2013brain axes, and potentially adipose\u2013liver and liver\u2013pancreas axes, partly via context- and tissue-dependent regulation of AMPK-, PI3K-AKT-, and SIRT1-related pathways. Strategies such as structural engineering, surface functionalization, and cargo loading optimization may further enhance the stability, bioavailability, and targeting capacity of PDNVs, thereby supporting their application in metabolic diseases.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05063","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:07:10Z","timestamp":1789668430000},"page":"27323-27345","source":"Crossref","is-referenced-by-count":0,"title":["Plant-Derived Nanovesicles\nas a Cross-Kingdom Therapeutic\nApproach for T2DM and Related Metabolic Disorders: Current Evidence\nand Future Perspectives"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0438-2292","authenticated-orcid":true,"given":"Yang","family":"Yu","sequence":"first","affiliation":[{"name":"Jiangsu University , , 301 Xuefu Road , , ,","place":["Zhenjiang, Jiangsu, China, 212013"]},{"name":"The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University , , , ,","place":["Taizhou, Jiangsu, China, 225300"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Shan","sequence":"additional","affiliation":[{"name":"Shanghai University of TCM , , ,","place":["Shanghai, China, 200082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu University , , 301 Xuefu Road , , ,","place":["Zhenjiang, Jiangsu, China, 212013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Ding","sequence":"additional","affiliation":[{"name":"Jiangsu University , , 301 Xuefu Road , , ,","place":["Zhenjiang, Jiangsu, China, 212013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-3196","authenticated-orcid":true,"given":"Hui","family":"Qian","sequence":"additional","affiliation":[{"name":"Jiangsu University , , 301 Xuefu Road , , ,","place":["Zhenjiang, Jiangsu, China, 212013"]},{"name":"Affiliated Kunshan Hospital of Jiangsu University , , , ,","place":["Kunshan, Jiangsu, China, 215300"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026091714070333000_cit1","doi-asserted-by":"publisher","first-page":"6605","DOI":"10.2147\/DDDT.S525690","article-title":"Comparative Analysis of Pioglitazone\nand Tirzepatide on Body Weight, Glucose Levels, Neuroinflammation,\nand Oxidative Stress in Diabetic Rats","volume":"19","author":"Alhowail","year":"2025","journal-title":"Drug\nDes., Dev. Ther."},{"issue":"1","key":"2026091714070333000_cit2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.7150\/thno.114415","article-title":"A convective transport-enhanced\nmulti-organoid device for therapeutic modeling of the liver-pancreas\naxis in obesity","volume":"16","author":"Kim","year":"2026","journal-title":"Theranostics"},{"issue":"1","key":"2026091714070333000_cit3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41574-023-00898-1","article-title":"Inter-organ crosstalk during development\nand progression of type 2 diabetes mellitus","volume":"20","author":"Xourafa","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"issue":"7785","key":"2026091714070333000_cit4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41586-019-1797-8","article-title":"The integrative\nbiology of type 2 diabetes","volume":"576","author":"Roden","year":"2019","journal-title":"Nature"},{"issue":"11","key":"2026091714070333000_cit5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41580-021-00390-6","article-title":"The aetiology and molecular landscape\nof insulin resistance","volume":"22","author":"James","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026091714070333000_cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101304","article-title":"Insulin action at a molecular level - 100 years of\nprogress","volume":"52","author":"White","year":"2021","journal-title":"Mol. Metab."},{"issue":"2","key":"2026091714070333000_cit7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00125-018-4777-x","article-title":"The many\nsecret lives of adipocytes: implications for diabetes","volume":"62","author":"Scherer","year":"2019","journal-title":"Diabetologia"},{"issue":"10","key":"2026091714070333000_cit8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrendo.2016.86","article-title":"Pharmacology and\ntherapeutic implications\nof current drugs for type 2 diabetes mellitus","volume":"12","author":"Tahrani","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"issue":"19","key":"2026091714070333000_cit9","doi-asserted-by":"publisher","DOI":"10.3390\/cells13191662","article-title":"Inflammatory\nTrajectory of Type 2 Diabetes: Novel Opportunities for Early and Late\nTreatment","volume":"13","author":"Pellegrini","year":"2024","journal-title":"Cells"},{"issue":"1","key":"2026091714070333000_cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-024-01325-9","article-title":"Research advances in\nthe anti-inflammatory effects of SGLT inhibitors in type 2 diabetes\nmellitus","volume":"16","author":"Zhang","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"issue":"1","key":"2026091714070333000_cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00313-5","article-title":"The role and\napplications\nof extracellular vesicles in osteoporosis","volume":"12","author":"Fang","year":"2024","journal-title":"Bone\nRes."},{"key":"2026091714070333000_cit12","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066","article-title":"Biological\nproperties of extracellular vesicles and their physiological functions","volume":"4","author":"Yanez-Mo","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"31","key":"2026091714070333000_cit13","doi-asserted-by":"publisher","first-page":"10959","DOI":"10.1080\/10408398.2022.2081667","article-title":"The potential\nrole of extracellular vesicles in bioactive compound-based therapy:\nA review of recent developments","volume":"63","author":"Liu","year":"2023","journal-title":"Crit. Rev.\nFood Sci. Nutr."},{"issue":"9","key":"2026091714070333000_cit14","doi-asserted-by":"publisher","first-page":"8667","DOI":"10.1021\/acsnano.4c15201","article-title":"Static Topographical\nCue Combined with Dynamic Fluid Stimulation Enhances the Macrophage\nExtracellular Vesicle Yield and Therapeutic Potential for Bone Defects","volume":"19","author":"Huang","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"2026091714070333000_cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-022-00210-0","article-title":"Extracellular\nvesicles in idiopathic pulmonary fibrosis: pathogenesis and therapeutics","volume":"42","author":"Fujita","year":"2022","journal-title":"Inflamm. Regen."},{"key":"2026091714070333000_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2024.102672","article-title":"Messenger and message: Uncovering\nthe roles, rhythm and regulation\nof extracellular vesicles in plant biotic interactions","volume":"83","author":"Qiao","year":"2025","journal-title":"Curr. Opin. Plant Biol."},{"issue":"6","key":"2026091714070333000_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12048","article-title":"A call for Rigor\nand standardization\nin plant extracellular vesicle research","volume":"10","author":"Pinedo","year":"2021","journal-title":"J.\nExtracell. Vesicles"},{"issue":"2","key":"2026091714070333000_cit18","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.fmre.2023.09.007","article-title":"Plant-derived nanovesicles: Promising therapeutics and drug delivery\nnanoplatforms for brain disorders","volume":"5","author":"Wang","year":"2025","journal-title":"Fundam. Res."},{"issue":"7","key":"2026091714070333000_cit19","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11071806","article-title":"Plant Exosome-like Nanovesicles and Their Role in the Innovative\nDelivery of RNA Therapeutics","volume":"11","author":"Chen","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"2026091714070333000_cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01657-6","article-title":"Exosome-like nanovesicles\nderived from Phellinus linteus inhibit Mical2 expression through cross-kingdom\nregulation and inhibit ultraviolet-induced skin aging","volume":"20","author":"Han","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"23","key":"2026091714070333000_cit21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262311261","article-title":"Isolation\nof Red Beet Plant-Derived\nNanovesicles, and Characterization of Their Molecular Content and\nBiological Activities in Human Cells","volume":"26","author":"Zanotti","year":"2025","journal-title":"Int. J.\nMol. Sci."},{"issue":"2","key":"2026091714070333000_cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021154","article-title":"microRNAs: Key Regulators\nin Plant Responses to Abiotic and Biotic Stresses via Endogenous and\nCross-Kingdom Mechanisms","volume":"25","author":"Ding","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"2026091714070333000_cit23","doi-asserted-by":"publisher","first-page":"13159","DOI":"10.1021\/acs.jafc.5c01547","article-title":"Plant-Derived\nNanovesicles: A Promising Frontier in Tissue Repair and Antiaging","volume":"73","author":"Zheng","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"2026091714070333000_cit24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ajps.2021.05.006","article-title":"Plant-derived exosome-like nanoparticles\nand their therapeutic activities","volume":"17","author":"Kim","year":"2022","journal-title":"Asian J. Pharm.\nSci."},{"key":"2026091714070333000_cit25","doi-asserted-by":"publisher","first-page":"10023","DOI":"10.2147\/IJN.S478589","article-title":"Tangerine Peel-Derived Exosome-Like Nanovesicles Alleviate Hepatic\nSteatosis Induced by Type 2 Diabetes: Evidenced by Regulating Lipid\nMetabolism and Intestinal Microflora","volume":"19","author":"Zou","year":"2024","journal-title":"Int. J.\nNanomed."},{"key":"2026091714070333000_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155854","article-title":"Hypericum\nperforatum-derived exosomes-like nanovesicles for adipose tissue photodynamic\ntherapy","volume":"132","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"2026091714070333000_cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0563-7","article-title":"Adipocyte\nmetabolism is improved by TNF receptor-targeting small RNAs identified\nfrom dried nuts","volume":"2","author":"Aquilano","year":"2019","journal-title":"Commun. Biol."},{"issue":"3","key":"2026091714070333000_cit28","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.7150\/thno.65427","article-title":"Garlic\nexosome-like nanoparticles\nreverse high-fat diet induced obesity via the gut\/brain axis","volume":"12","author":"Sundaram","year":"2022","journal-title":"Theranostics"},{"issue":"10","key":"2026091714070333000_cit29","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1039\/D3MH01030A","article-title":"Plant exosome nanovesicles (PENs):\ngreen delivery platforms","volume":"10","author":"Cao","year":"2023","journal-title":"Mater. Horiz."},{"issue":"10","key":"2026091714070333000_cit30","doi-asserted-by":"publisher","DOI":"10.3390\/foods8100440","article-title":"Targeting Gut Microbiota\nfor the Prevention and Management of Diabetes Mellitus by Dietary\nNatural Products","volume":"8","author":"Li","year":"2019","journal-title":"Foods"},{"issue":"16","key":"2026091714070333000_cit31","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163369","article-title":"Insoluble\nand Soluble Dietary Fibers from Kiwifruit (Actinidia deliciosa) Modify\nGut Microbiota to Alleviate High-Fat Diet and Streptozotocin-Induced\nTYPE 2 Diabetes in Rats","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"2026091714070333000_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154844","article-title":"Intestine-liver crosstalk\nin Type 2 Diabetes and non-alcoholic fatty liver disease","volume":"123","author":"Nawrot","year":"2021","journal-title":"Metabolism"},{"issue":"11","key":"2026091714070333000_cit33","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.1007\/s00210-024-03204-6","article-title":"The gut-liver axis: emerging mechanisms\nand therapeutic\napproaches for nonalcoholic fatty liver disease and type 2 diabetes\nmellitus","volume":"397","author":"Bhardwaj","year":"2024","journal-title":"Naunyn-Schmiedeberg\u2019s Arch.\nPharmacol."},{"issue":"12","key":"2026091714070333000_cit34","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic\nfatty\nliver disease: the interplay between metabolism, microbes and immunity","volume":"3","author":"Tilg","year":"2021","journal-title":"Nat. Metab."},{"issue":"1","key":"2026091714070333000_cit35","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-ad08","article-title":"Addendum. 2. Classification and Diagnosis of Diabetes:\nStandards of Care in Diabetes\u25002023. Diabetes Care 2023;46(Suppl.\n1):S19\u2013S40","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"issue":"9682","key":"2026091714070333000_cit36","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/S0140-6736(09)60619-X","article-title":"Trajectories of glycaemia, insulin sensitivity, and\ninsulin secretion before diagnosis of type 2 diabetes: an analysis\nfrom the Whitehall II study","volume":"373","author":"Tabak","year":"2009","journal-title":"Lancet"},{"key":"2026091714070333000_cit37","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0374-9","article-title":"Cohort profile:\nthe German Diabetes Study (GDS)","volume":"15","author":"Szendroedi","year":"2016","journal-title":"Cardiovasc.\nDiabetol."},{"issue":"5","key":"2026091714070333000_cit38","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/1873-3468.14282","article-title":"Interorgan crosstalk\nin pancreatic islet function and pathology","volume":"596","author":"Evans","year":"2022","journal-title":"FEBS Lett."},{"issue":"6","key":"2026091714070333000_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.468","article-title":"Emerging roles of exosomal\nmiRNAs in diabetes mellitus","volume":"11","author":"He","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"2026091714070333000_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154892","article-title":"Insulin resistance\nand insulin sensitizing agents","volume":"125","author":"Mastrototaro","year":"2021","journal-title":"Metabolism"},{"issue":"6","key":"2026091714070333000_cit41","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41580-021-00354-w","article-title":"MicroRNA-mediated\nregulation of glucose and lipid metabolism","volume":"22","author":"Agbu","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"2026091714070333000_cit42","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","article-title":"Exosomes as mediators\nof intercellular crosstalk in metabolism","volume":"33","author":"Isaac","year":"2021","journal-title":"Cell\nMetab."},{"key":"2026091714070333000_cit43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1146\/annurev-pharmtox-052220-010446","article-title":"Central Nervous\nSystem Control of\nGlucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?","volume":"62","author":"Mirzadeh","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"10","key":"2026091714070333000_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100270","article-title":"Serum dihydroceramides correlate\nwith insulin sensitivity in humans and decrease insulin sensitivity\nin vitro","volume":"63","author":"Zarini","year":"2022","journal-title":"J. Lipid Res."},{"key":"2026091714070333000_cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.684448","article-title":"Circulating\nCeramides- Are Origins\nImportant for Sphingolipid Biomarkers and Treatments?","volume":"12","author":"Mah","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"6","key":"2026091714070333000_cit46","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.2337\/dc17-1318","article-title":"Specific Hepatic\nSphingolipids Relate to Insulin Resistance, Oxidative Stress, and\nInflammation in Nonalcoholic Steatohepatitis","volume":"41","author":"Apostolopoulou","year":"2018","journal-title":"Diabetes Care"},{"key":"2026091714070333000_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101261","article-title":"Insulin action,\ntype 2 diabetes, and branched-chain\namino acids: A two-way street","volume":"52","author":"White","year":"2021","journal-title":"Mol. Metab."},{"issue":"7","key":"2026091714070333000_cit48","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00125-018-4619-x","article-title":"Circulating amino acids\nand the risk of macrovascular, microvascular and mortality outcomes\nin individuals with type 2 diabetes: results from the ADVANCE trial","volume":"61","author":"Welsh","year":"2018","journal-title":"Diabetologia"},{"issue":"16","key":"2026091714070333000_cit49","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121434","article-title":"The circulating metabolome of human starvation","volume":"3","author":"Steinhauser","year":"2018","journal-title":"JCI Insight"},{"key":"2026091714070333000_cit50","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1029890","article-title":"Role of gut\nmicrobiota in the pathogenesis and treatment of diabetes mullites:\nAdvanced research-based review","volume":"13","author":"Ye","year":"2022","journal-title":"Front. Microbiol."},{"key":"2026091714070333000_cit51","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.metabol.2018.09.007","article-title":"PPARgamma\nis a major regulator of\nbranched-chain amino acid blood levels and catabolism in white and\nbrown adipose tissues","volume":"89","author":"Blanchard","year":"2018","journal-title":"Metabolism"},{"issue":"5","key":"2026091714070333000_cit52","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/s00125-023-05879-7","article-title":"Causal\nfactors underlying diabetes\nrisk informed by Mendelian randomisation analysis: evidence, opportunities\nand challenges","volume":"66","author":"Yuan","year":"2023","journal-title":"Diabetologia"},{"issue":"3","key":"2026091714070333000_cit53","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1152\/physrev.00015.2017","article-title":"Interorgan Metabolic\nCrosstalk in Human Insulin Resistance","volume":"98","author":"Gancheva","year":"2018","journal-title":"Physiol.\nRev."},{"issue":"4","key":"2026091714070333000_cit54","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.cmet.2020.08.001","article-title":"A Membrane-Bound\nDiacylglycerol Species Induces PKC\u03f5-Mediated Hepatic Insulin\nResistance","volume":"32","author":"Lyu","year":"2020","journal-title":"Cell Metab."},{"issue":"4","key":"2026091714070333000_cit55","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139946","article-title":"Short-term overnutrition\ninduces\nwhite adipose tissue insulin resistance through sn-1,2-diacylglycerol\/PKCepsilon\/insulin\nreceptor Thr1160 phosphorylation","volume":"6","author":"Lyu","year":"2021","journal-title":"JCI Insight"},{"issue":"38","key":"2026091714070333000_cit56","doi-asserted-by":"publisher","first-page":"E8996","DOI":"10.1073\/pnas.1804379115","article-title":"PKCepsilon contributes to lipid-induced insulin resistance\nthrough cross talk with p70S6K and through previously unknown regulators\nof insulin signaling","volume":"115","author":"Gassaway","year":"2018","journal-title":"Proc. Natl. Acad. Sci.\nU.S.A."},{"issue":"4","key":"2026091714070333000_cit57","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.2337\/dc21-1705","article-title":"Metabolomics\nand Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis\nof Prospective Cohort Studies","volume":"45","author":"Morze","year":"2022","journal-title":"Diabetes Care"},{"issue":"10","key":"2026091714070333000_cit58","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41580-018-0044-8","article-title":"Metabolites as regulators of insulin\nsensitivity and metabolism","volume":"19","author":"Yang","year":"2018","journal-title":"Nat. Rev. Mol. Cell\nBiol."},{"issue":"12","key":"2026091714070333000_cit59","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41577-019-0213-9","article-title":"Targeting\ninnate immune mediators\nin type 1 and type 2 diabetes","volume":"19","author":"Donath","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"2026091714070333000_cit60","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic Adipose Tissue Inflammation\nLinking Obesity to Insulin Resistance and Type 2 Diabetes","volume":"10","author":"Zatterale","year":"2019","journal-title":"Front. Physiol."},{"issue":"1","key":"2026091714070333000_cit61","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1172\/JCI88877","article-title":"Islet inflammation\nin type 2 diabetes and physiology","volume":"127","author":"Eguchi","year":"2017","journal-title":"J. Clin.\nInvest."},{"issue":"2","key":"2026091714070333000_cit62","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cmet.2018.12.003","article-title":"Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting\nbeta Cell Proliferation and Function in Obesity","volume":"29","author":"Ying","year":"2019","journal-title":"Cell Metab."},{"key":"2026091714070333000_cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101122","article-title":"Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment\nconcepts in humans","volume":"50","author":"Pafili","year":"2021","journal-title":"Mol. Metab."},{"key":"2026091714070333000_cit64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01582","article-title":"The Effects\nof Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front. Immunol."},{"key":"2026091714070333000_cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1617478","article-title":"Anion exchange chromatography-based purification of plant-derived\nnanovesicles from Brassica oleracea L.: molecular profiling and bioactivity\nin human cells","volume":"13","author":"Zanotti","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"2026091714070333000_cit66","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02120-w","article-title":"Natural exosomes-like\nnanoparticles\nin mung bean sprouts possesses anti-diabetic effects via activation\nof PI3K\/Akt\/GLUT4\/GSK-3beta signaling pathway","volume":"21","author":"He","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"20","key":"2026091714070333000_cit67","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202308680","article-title":"Outer Membrane Vesicles Released\nfrom Garlic Exosome-like Nanoparticles (GaELNs) Train Gut Bacteria\nthat Reverses Type 2 Diabetes via the Gut-Brain Axis","volume":"20","author":"Sundaram","year":"2024","journal-title":"Small"},{"issue":"4","key":"2026091714070333000_cit68","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202409501","article-title":"MicroRNAs\nDependent G-ELNs Based Intervention Improves Glucose and Fatty Acid\nMetabolism While Protecting Pancreatic beta-Cells in Type 2 Diabetic\nMice","volume":"21","author":"Bajaj","year":"2025","journal-title":"Small"},{"issue":"12","key":"2026091714070333000_cit69","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.7150\/thno.97096","article-title":"Exosome-like nanoparticles derived\nfrom fruits, vegetables, and herbs: innovative strategies of therapeutic\nand drug delivery","volume":"14","author":"Zhao","year":"2024","journal-title":"Theranostics"},{"issue":"31","key":"2026091714070333000_cit70","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202502001","article-title":"Oral Plant-Derived\nNanomedicines Mitigate Acetaminophen-Induced Liver\nInjury by Modulating the Gut-Liver Axis and Intestinal Microbiota\nMetabolism","volume":"21","author":"Chen","year":"2025","journal-title":"Small"},{"issue":"1","key":"2026091714070333000_cit71","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00889-1","article-title":"Plant-derived\nextracellular vesicles: a novel nanomedicine approach with advantages\nand challenges","volume":"20","author":"Nemati","year":"2022","journal-title":"Cell Commun. Signaling"},{"key":"2026091714070333000_cit72","doi-asserted-by":"publisher","first-page":"12793","DOI":"10.2147\/IJN.S496664","article-title":"Engineering\nStrategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge\nand Future Perspectives","volume":"19","author":"Li","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"2026091714070333000_cit73","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0022-5320(67)80128-X","article-title":"Ultrastructural\nchanges during growth and embryogenesis\nin carrot cell cultures","volume":"18","author":"Halperin","year":"1967","journal-title":"J. Ultrastruct. Res."},{"issue":"3","key":"2026091714070333000_cit74","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1104\/pp.19.00381","article-title":"Turnip Mosaic Virus Components Are Released into the Extracellular\nSpace by Vesicles in Infected Leaves","volume":"180","author":"Movahed","year":"2019","journal-title":"Plant\nPhysiol."},{"key":"2026091714070333000_cit75","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.2147\/IJN.S420748","article-title":"Plant-Derived Exosome-Like Nanovesicles:\nCurrent Progress and Prospects","volume":"18","author":"Mu","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"2026091714070333000_cit76","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ymthe.2024.02.021","article-title":"Plant-derived\nvesicle-like nanoparticles: A new tool for inflammatory bowel disease\nand colitis-associated cancer treatment","volume":"32","author":"Fang","year":"2024","journal-title":"Mol.\nTher."},{"issue":"5","key":"2026091714070333000_cit77","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.70090","article-title":"Arabidopsis Produces Distinct Subpopulations\nof Extracellular Vesicles That Respond Differentially to Biotic Stress,\nAltering Growth and Infectivity of a Fungal Pathogen","volume":"14","author":"Koch","year":"2025","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"2026091714070333000_cit78","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01195-7","article-title":"Aloe derived nanovesicle as a functional\ncarrier for indocyanine green encapsulation and phototherapy","volume":"19","author":"Zeng","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026091714070333000_cit79","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02426-3","article-title":"Collision of herbal\nmedicine and nanotechnology: a bibliometric analysis of herbal nanoparticles\nfrom 2004 to 2023","volume":"22","author":"Ai","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026091714070333000_cit80","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.352","article-title":"Isolation\nof Extracellular Vesicles from Arabidopsis","volume":"2","author":"Chen","year":"2022","journal-title":"Curr. Protoc."},{"issue":"24","key":"2026091714070333000_cit81","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207826","article-title":"Plant-Derived\nVesicle-Like Nanoparticles as Promising Biotherapeutic Tools: Present\nand Future","volume":"35","author":"Feng","year":"2023","journal-title":"Adv. Mater."},{"issue":"11","key":"2026091714070333000_cit82","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.70026","article-title":"Isolation of Small Extracellular Vesicles (sEVs) from\nthe Apoplastic Wash Fluid of Nicotiana benthamiana Leaves","volume":"4","author":"Eldahshoury","year":"2024","journal-title":"Curr. Protoc."},{"issue":"8","key":"2026091714070333000_cit83","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300669","article-title":"A review on separation and application of plant-derived exosome-like\nnanoparticles","volume":"47","author":"Liu","year":"2024","journal-title":"J. Sep. Sci."},{"issue":"22","key":"2026091714070333000_cit84","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212092","article-title":"Plant-Derived\nExosome-like Nanoparticles: A Comprehensive Overview of Their Composition,\nBiogenesis, Isolation, and Biological Applications","volume":"25","author":"Sha","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2026091714070333000_cit85","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.24858","article-title":"The impact\nof disparate isolation methods for extracellular vesicles on downstream\nRNA profiling","volume":"3","author":"Van Deun","year":"2014","journal-title":"J. Extracell. Vesicles"},{"issue":"12","key":"2026091714070333000_cit86","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1007\/s00018-019-03071-y","article-title":"Extracellular\nvesicle isolation methods: rising impact of size-exclusion chromatography","volume":"76","author":"Monguio-Tortajada","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"2026091714070333000_cit87","doi-asserted-by":"publisher","first-page":"5","DOI":"10.17925\/ee.2024.20.2.2","article-title":"Metabolic\nDysfunction-associated\nSteatotic Liver Disease and Type 2 Diabetes: A Deadly Synergy","volume":"20","author":"Leith","year":"2024","journal-title":"touchREV. Endocrinol."},{"issue":"9","key":"2026091714070333000_cit88","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.2337\/dbi22-0004","article-title":"The\nLiver-alpha-Cell Axis in Health and in Disease","volume":"71","author":"Richter","year":"2022","journal-title":"Diabetes"},{"key":"2026091714070333000_cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111315","article-title":"Adipose tissue and insulin resistance\nin obese","volume":"137","author":"Ahmed","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"2026091714070333000_cit90","doi-asserted-by":"publisher","DOI":"10.1126\/science.adp4120","article-title":"Liver ALKBH5 regulates glucose and\nlipid homeostasis independently through GCGR and mTORC1 signaling","volume":"387","author":"Ding","year":"2025","journal-title":"Science"},{"issue":"9","key":"2026091714070333000_cit91","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094820","article-title":"The Mighty\nMitochondria Are Unifying Organelles and Metabolic Hubs in Multiple\nOrgans of Obesity, Insulin Resistance, Metabolic Syndrome, and Type\n2 Diabetes: An Observational Ultrastructure Study","volume":"23","author":"Hayden","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026091714070333000_cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155382","article-title":"Artesunate improves\nglucose and lipid\nmetabolism in db\/db mice by regulating the metabolic profile and the\nMAPK\/PI3K\/Akt signalling pathway","volume":"126","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"2026091714070333000_cit93","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.chom.2018.10.001","article-title":"Plant-Derived Exosomal\nMicroRNAs Shape the Gut Microbiota","volume":"24","author":"Teng","year":"2018","journal-title":"Cell Host\nMicrobe"},{"key":"2026091714070333000_cit94","doi-asserted-by":"publisher","first-page":"13991","DOI":"10.2147\/IJN.S493434","article-title":"Houttuynia cordata-Derived\nExosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition\nof the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota","volume":"19","author":"Li","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"31","key":"2026091714070333000_cit95","doi-asserted-by":"publisher","first-page":"7718","DOI":"10.1080\/10408398.2025.2479066","article-title":"Colon health benefits of plant-derived exosome-like\nnanoparticles via modulating gut microbiota and immunity","volume":"65","author":"Han","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"16","key":"2026091714070333000_cit96","doi-asserted-by":"publisher","first-page":"7520","DOI":"10.1039\/D3FO01094E","article-title":"Garlic-derived exosome-like\nnanovesicles alleviate dextran sulphate sodium-induced mouse colitis\nvia the TLR4\/MyD88\/NF-kappaB pathway and gut microbiota modulation","volume":"14","author":"Zhu","year":"2023","journal-title":"Food Funct."},{"issue":"20","key":"2026091714070333000_cit97","doi-asserted-by":"publisher","first-page":"5361","DOI":"10.1039\/D4BM00812J","article-title":"Hemp sprout-derived\nexosome-like nanovesicles as hepatoprotective\nagents attenuate liver fibrosis","volume":"12","author":"Kim","year":"2024","journal-title":"Biomater. Sci."},{"key":"2026091714070333000_cit98","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1753393","article-title":"Synergistic\ntherapeutic strategies for metabolic dysfunction-associated steatohepatitis\nand type 2 diabetes mellitus: molecular insights and clinical advances","volume":"16","author":"Zhu","year":"2025","journal-title":"Front. Endocrinol."},{"key":"2026091714070333000_cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110137","article-title":"The effect\nof Berberine on weight\nloss in order to prevent obesity: A systematic review","volume":"127","author":"Ilyas","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"2026091714070333000_cit100","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1089\/zeb.2024.0154","article-title":"Candidate Gene Expression\nin Adult Zebrafish Models of Type 2 Diabetes Mellitus","volume":"21","author":"Shezi","year":"2024","journal-title":"Zebrafish"},{"issue":"1","key":"2026091714070333000_cit101","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01951-9","article-title":"Type 2 diabetes\nmellitus in adults: pathogenesis, prevention and therapy","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduction Target Ther."},{"issue":"1","key":"2026091714070333000_cit102","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3350\/cmh.2022.0237","article-title":"Pathogenesis and\ntreatment of non-alcoholic steatohepatitis and its fibrosis","volume":"29","author":"Lee","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"issue":"2","key":"2026091714070333000_cit103","doi-asserted-by":"publisher","first-page":"105","DOI":"10.7570\/jomes25025","article-title":"Human Adipose Tissue\nMetabolism in Obesity","volume":"34","author":"Lin","year":"2025","journal-title":"J. Obesity Metab. Syndr."},{"issue":"3","key":"2026091714070333000_cit104","doi-asserted-by":"publisher","DOI":"10.1530\/joe-24-0115","article-title":"The role of adipose tissue dysfunction\nin hepatic insulin resistance and T2D","volume":"262","author":"Sancar","year":"2024","journal-title":"J. Endocrinol."},{"issue":"25","key":"2026091714070333000_cit105","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.3748\/wjg.v29.i25.3999","article-title":"Insulin resistance and adipose tissue\ninteractions as the cornerstone of metabolic (dysfunction)-associated\nfatty liver disease pathogenesis","volume":"29","author":"Pal","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"2026091714070333000_cit106","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.jhep.2019.06.031","article-title":"Crosstalk\nbetween adipose tissue insulin resistance and liver macrophages in\nnon-alcoholic fatty liver disease","volume":"71","author":"Rosso","year":"2019","journal-title":"J. Hepatol."},{"issue":"11","key":"2026091714070333000_cit107","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1111\/liv.15377","article-title":"Adipose tissue\ndysfunction and visceral fat are associated with hepatic insulin resistance\nand severity of NASH even in lean individuals","volume":"42","author":"Saponaro","year":"2022","journal-title":"Liver Int."},{"issue":"4","key":"2026091714070333000_cit108","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cmet.2021.03.007","article-title":"Direct and\nindirect control of hepatic glucose production\nby insulin","volume":"33","author":"Lewis","year":"2021","journal-title":"Cell Metab."},{"issue":"12","key":"2026091714070333000_cit109","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v16.i12.114395","article-title":"Immune\nactivation induced by dysregulated lipid metabolism in the pathogenesis\nof type 2 diabetes","volume":"16","author":"Yang","year":"2025","journal-title":"World J. Diabetes"},{"key":"2026091714070333000_cit110","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.834485","article-title":"Gut Microbiota:\nAn Important Player in Type 2 Diabetes Mellitus","volume":"12","author":"Zhou","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"2026091714070333000_cit111","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000448957","article-title":"Gut Microbiota,\nBacterial Translocation, and Interactions with Diet: Pathophysiological\nLinks between Major Depressive Disorder and Non-Communicable Medical\nComorbidities","volume":"86","author":"Slyepchenko","year":"2016","journal-title":"Psychother. Psychosom."},{"key":"2026091714070333000_cit112","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112839","article-title":"Gut microbiota-derived\nmetabolites as key actors in type 2 diabetes\nmellitus","volume":"149","author":"Du","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"2026091714070333000_cit113","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123719","article-title":"Role of\nGut Microbiota on Onset and Progression of Microvascular Complications\nof Type 2 Diabetes (T2DM)","volume":"12","author":"Tanase","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"2026091714070333000_cit114","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1842990","article-title":"Phlorizin ameliorates\nobesity-associated endotoxemia and insulin resistance in high-fat\ndiet-fed mice by targeting the gut microbiota and intestinal barrier\nintegrity","volume":"12","author":"Zhang","year":"2020","journal-title":"Gut Microbes"},{"issue":"4","key":"2026091714070333000_cit115","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-025-01433-5","article-title":"Smilax china\nL. Polysaccharide\nAlleviates HFD-induced Insulin Resistance via Modulating Gut Microbiota\nand AMPK\/PI3K\/AKT Signaling Pathway in Mice","volume":"80","author":"Wang","year":"2025","journal-title":"Plant Foods Hum. Nutr."},{"key":"2026091714070333000_cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.116671","article-title":"Poria cocos polysaccharides\nalleviate obesity-related adipose tissue\ninsulin resistance via gut microbiota-derived short-chain fatty acids\nactivation of FGF21\/PI3K\/AKT signaling","volume":"215","author":"Liu","year":"2025","journal-title":"Food\nRes. Int."},{"issue":"4","key":"2026091714070333000_cit117","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70088","article-title":"Pomegranate-Derived\nExosome-Like Nanovesicles Containing Ellagic Acid Alleviate Gut Leakage\nand Liver Injury in MASLD","volume":"13","author":"Kim","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"2026091714070333000_cit118","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131307","article-title":"Complexation of ellagic acid with\nalpha-lactalbumin and its antioxidant\nproperty","volume":"372","author":"Diao","year":"2022","journal-title":"Food Chem."},{"issue":"18","key":"2026091714070333000_cit119","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810937","article-title":"Ellagic Acid and Its\nAnti-Aging Effects on Central Nervous System","volume":"23","author":"Zhu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026091714070333000_cit120","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1161521","article-title":"Obesity and\ntype 2 diabetes mellitus: connections in epidemiology, pathogenesis,\nand treatments","volume":"14","author":"Ruze","year":"2023","journal-title":"Front. Endocrinol."},{"key":"2026091714070333000_cit121","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbi.2024.09.008","article-title":"Phlorizin ameliorates cognitive and behavioral impairments via the\nmicrobiota-gut-brain axis in high-fat and high-fructose diet-induced\nobese male mice","volume":"123","author":"Zhang","year":"2025","journal-title":"Brain, Behav., Immun."},{"key":"2026091714070333000_cit122","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.144852","article-title":"Microbe-dependent and\nindependent effects of diet on\nmetabolic inflammation in glucose metabolism regulation","volume":"488","author":"Li","year":"2025","journal-title":"Food Chem."},{"key":"2026091714070333000_cit123","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00478","article-title":"MicroRNA-146a:\nA Comprehensive Indicator of Inflammation and Oxidative Stress Status\nInduced in the Brain of Chronic T2DM Rats","volume":"9","author":"Xie","year":"2018","journal-title":"Front.\nPharmacol."},{"key":"2026091714070333000_cit124","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00022","article-title":"Adipose\nTissue Distribution, Inflammation\nand Its Metabolic Consequences, Including Diabetes and Cardiovascular\nDisease","volume":"7","author":"Chait","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"5\u20136","key":"2026091714070333000_cit125","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1101\/gad.346312.120","article-title":"Chronic tissue inflammation and metabolic\ndisease","volume":"35","author":"Lee","year":"2021","journal-title":"Genes Dev."},{"issue":"Pt 2","key":"2026091714070333000_cit126","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113499","article-title":"Tirzepatide\u2019s role in targeting\nadipose tissue macrophages to reduce obesity-related inflammation\nand improve insulin resistance","volume":"143","author":"Xia","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"2026091714070333000_cit127","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-10466-7","article-title":"The role of plant-derived extracellular\nvesicles in ameliorating\nchronic diseases","volume":"52","author":"Tiwari","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"2026091714070333000_cit128","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ymthe.2020.11.030","article-title":"Plant Exosome-like Nanovesicles:\nEmerging Therapeutics\nand Drug Delivery Nanoplatforms","volume":"29","author":"Dad","year":"2021","journal-title":"Mol. Ther."},{"issue":"1","key":"2026091714070333000_cit129","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03602-9","article-title":"Exploring\nthe bioactivity of MicroRNAs Originated from Plant-derived Exosome-like\nNanoparticles (PELNs): current perspectives","volume":"23","author":"Tembo","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"2026091714070333000_cit130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jare.2024.04.001","article-title":"Ginger exosome-like\nnanoparticle-derived miRNA therapeutics: A strategic inhibitor of\nintestinal inflammation","volume":"69","author":"Yan","year":"2025","journal-title":"J. Adv. Res."},{"key":"2026091714070333000_cit131","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.2147\/IJN.S425173","article-title":"Identifying the Potential\nof miRNAs in Houttuynia cordata-Derived\nExosome-Like Nanoparticles Against Respiratory RNA Viruses","volume":"18","author":"Zhu","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"2026091714070333000_cit132","doi-asserted-by":"publisher","first-page":"6745","DOI":"10.1021\/acs.jafc.5c01990","article-title":"Tea Extracellular Vesicle-Derived\nMicroRNAs Contribute to Alleviate Intestinal Inflammation by Reprogramming\nMacrophages","volume":"73","author":"Luo","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"7978","key":"2026091714070333000_cit133","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41586-023-06466-x","article-title":"Gut microbial\ncarbohydrate\nmetabolism contributes to insulin resistance","volume":"621","author":"Takeuchi","year":"2023","journal-title":"Nature"},{"issue":"5","key":"2026091714070333000_cit134","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut microbial\nmetabolites in obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nat.\nRev. Endocrinol."},{"key":"2026091714070333000_cit135","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1554189","article-title":"Gut microbiota\nand its metabolites regulate insulin resistance: traditional Chinese\nmedicine insights for T2DM","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Microbiol."},{"issue":"8","key":"2026091714070333000_cit136","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1016\/j.apsb.2022.12.022","article-title":"Plant-derived\nnanovesicles: Further exploration of biomedical function and application\npotential","volume":"13","author":"Li","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"2026091714070333000_cit137","doi-asserted-by":"publisher","DOI":"10.3390\/foods9121852","article-title":"Biomanufacturing of Tomato-Derived\nNanovesicles","volume":"9","author":"Bokka","year":"2020","journal-title":"Foods"},{"issue":"1","key":"2026091714070333000_cit138","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02193-7","article-title":"Plant-derived\nnanovesicles: harnessing nature\u2019s power for\ntissue protection and repair","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"7","key":"2026091714070333000_cit139","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.ymthe.2017.01.025","article-title":"Broccoli-Derived Nanoparticle Inhibits Mouse Colitis\nby Activating Dendritic Cell AMP-Activated Protein Kinase","volume":"25","author":"Deng","year":"2017","journal-title":"Mol. Ther."},{"issue":"6","key":"2026091714070333000_cit140","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202105385","article-title":"Restoring Oat Nanoparticles\nMediated Brain Memory Function\nof Mice Fed Alcohol by Sorting Inflammatory Dectin-1 Complex Into\nMicroglial Exosomes","volume":"18","author":"Xu","year":"2022","journal-title":"Small"},{"issue":"12","key":"2026091714070333000_cit141","doi-asserted-by":"publisher","first-page":"5798","DOI":"10.1039\/D2NR07018A","article-title":"Ginseng-derived\nexosome-like nanovesicles\nextracted by sucrose gradient ultracentrifugation to inhibit osteoclast\ndifferentiation","volume":"15","author":"Seo","year":"2023","journal-title":"Nanoscale"},{"issue":"1","key":"2026091714070333000_cit142","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1515\/med-2020-0160","article-title":"Biological\nproperties\nand therapeutic effects of plant-derived nanovesicles","volume":"15","author":"Di Gioia","year":"2020","journal-title":"Open Med."},{"issue":"7","key":"2026091714070333000_cit143","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/mt.2013.64","article-title":"Grape exosome-like nanoparticles\ninduce intestinal stem cells and protect mice from DSS-induced colitis","volume":"21","author":"Ju","year":"2013","journal-title":"Mol. Ther."},{"key":"2026091714070333000_cit144","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.isci.2019.10.032","article-title":"Plant-Derived Exosomal Nanoparticles\nInhibit Pathogenicity of Porphyromonas gingivalis","volume":"21","author":"Sundaram","year":"2019","journal-title":"iScience"},{"key":"2026091714070333000_cit145","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116543","article-title":"Research status\nand\nchallenges of plant-derived exosome-like nanoparticles","volume":"174","author":"Bai","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"2026091714070333000_cit146","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/mt.2013.190","article-title":"Targeted\ndrug delivery to intestinal macrophages by bioactive nanovesicles\nreleased from grapefruit","volume":"22","author":"Wang","year":"2014","journal-title":"Mol. Ther."},{"issue":"1","key":"2026091714070333000_cit147","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2026.102840","article-title":"Oral ginger-derived\nextracellular vesicles ameliorate arthritis via anti-inflammatory\nactions of microRNA-149 and 6-gingerol","volume":"37","author":"Kaneta","year":"2026","journal-title":"Mol.\nTher. Nucleic Acids"},{"key":"2026091714070333000_cit148","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121178","article-title":"Green\u2019\nnanotherapeutics from tea leaves for orally targeted prevention and\nalleviation of colon diseases","volume":"279","author":"Zu","year":"2021","journal-title":"Biomaterials"},{"issue":"3","key":"2026091714070333000_cit149","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202153365","article-title":"Exosome-like nanoparticles from Mulberry bark prevent\nDSS-induced colitis via the AhR\/COPS8 pathway","volume":"23","author":"Sriwastva","year":"2022","journal-title":"EMBO Rep."},{"issue":"1","key":"2026091714070333000_cit150","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02065-0","article-title":"Edible exosome-like\nnanoparticles from portulaca oleracea L mitigate DSS-induced colitis\nvia facilitating double-positive CD4(+)CD8(+)T cells expansion","volume":"21","author":"Zhu","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"5","key":"2026091714070333000_cit151","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jgr.2023.01.004","article-title":"Amelioration\nof colitis progression by ginseng-derived exosome-like nanoparticles\nthrough suppression of inflammatory cytokines","volume":"47","author":"Kim","year":"2023","journal-title":"J. Ginseng Res."},{"key":"2026091714070333000_cit152","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107071","article-title":"peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis\nby reshaping gut microbiota, especially by boosting the anti-colitic\nBacteroides thetaiotaomicron","volume":"200","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"14","key":"2026091714070333000_cit153","doi-asserted-by":"publisher","first-page":"7641","DOI":"10.1039\/D4FO01366B","article-title":"Allium tuberosum-derived nanovesicles\nwith anti-inflammatory\nproperties prevent DSS-induced colitis and modify the gut microbiome","volume":"15","author":"Kang","year":"2024","journal-title":"Food Funct."},{"issue":"1","key":"2026091714070333000_cit154","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144802","article-title":"miR166u -enriched\nPolygonatum sibiricum exosome-like nanoparticles alleviate colitis\nby improving intestinal barrier through the TLR4\/AKT pathway","volume":"318","author":"Wei","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026091714070333000_cit155","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1097\/cm9.0000000000003651","article-title":"\u2033One stone three\nbirds\u2033: Andrographis paniculata-derived exosome-like nanoparticles\nmitigate dextran sulfate sodium-induced colitis","volume":"139","author":"Zhu","year":"2025","journal-title":"Chin Med. J."},{"issue":"33","key":"2026091714070333000_cit156","doi-asserted-by":"publisher","first-page":"20818","DOI":"10.1021\/acs.jafc.5c05082","article-title":"Tangerine Peel Exosome-like\nNanoparticles (TPELNs)\nMitigate Intestinal Inflammation via Gut Microbiome Remodeling and\nImmune Modulation","volume":"73","author":"Tuo","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"42","key":"2026091714070333000_cit157","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202505921","article-title":"MicroRNA-Enriched Plant-Derived\nExosomes Alleviate Colitis by Modulating\nSystemic Immunity, Metabolic Homeostasis, and Gut Microbiota","volume":"12","author":"Shi","year":"2025","journal-title":"Adv. Sci."},{"issue":"3","key":"2026091714070333000_cit158","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.7150\/thno.62514","article-title":"Ginger\nnanoparticles mediated induction of Foxa2 prevents high-fat diet-induced\ninsulin resistance","volume":"12","author":"Kumar","year":"2022","journal-title":"Theranostics"},{"key":"2026091714070333000_cit159","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jconrel.2014.07.049","article-title":"Extracellular vesicles as drug delivery\nsystems: lessons from the liposome field","volume":"195","author":"van der Meel","year":"2014","journal-title":"J.\nControlled Release"},{"issue":"2","key":"2026091714070333000_cit160","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020277","article-title":"Resveratrol and\nGrape Extract-loaded Solid Lipid Nanoparticles for the Treatment of\nAlzheimer\u2019s Disease","volume":"22","author":"Loureiro","year":"2017","journal-title":"Molecules"},{"issue":"34","key":"2026091714070333000_cit161","doi-asserted-by":"publisher","first-page":"23117","DOI":"10.1021\/acsnano.4c05309","article-title":"Development and Evaluation of Reconstructed Nanovesicles from Turmeric\nfor Multifaceted Obesity Intervention","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"2026091714070333000_cit162","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/mt.2015.188","article-title":"Grapefruit-derived Nanovectors Delivering\nTherapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor\nProgression","volume":"24","author":"Zhuang","year":"2016","journal-title":"Mol. Ther."},{"issue":"1","key":"2026091714070333000_cit163","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32953-7","article-title":"Arrowtail RNA for Ligand\nDisplay on Ginger Exosome-like Nanovesicles\nto Systemic Deliver siRNA for Cancer Suppression","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"2026091714070333000_cit164","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2886","article-title":"Delivery\nof therapeutic agents by\nnanoparticles made of grapefruit-derived lipids","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."},{"key":"2026091714070333000_cit165","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122804","article-title":"Biomimetic\nnanoplatform with microbiome modulation and antioxidant functions\nameliorating insulin resistance and pancreatic beta-cell dysfunction\nfor T2DM management","volume":"313","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"issue":"3","key":"2026091714070333000_cit166","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s12010-017-2478-4","article-title":"Curcumin Encapsulated\nin Milk Exosomes Resists Human Digestion and Possesses Enhanced Intestinal\nPermeability in Vitro","volume":"183","author":"Vashisht","year":"2017","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"6","key":"2026091714070333000_cit167","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/aps.2017.12","article-title":"Engineering exosomes as refined biological\nnanoplatforms for drug delivery","volume":"38","author":"Luan","year":"2017","journal-title":"Acta Pharmacol.\nSin."},{"issue":"10","key":"2026091714070333000_cit168","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1038\/mt.2016.159","article-title":"Edible Ginger-derived\nNano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach\nfor Colon Cancer Therapy","volume":"24","author":"Zhang","year":"2016","journal-title":"Mol. Ther."},{"issue":"16","key":"2026091714070333000_cit169","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.2217\/nnm-2017-0196","article-title":"Oral administration\nof ginger-derived nanolipids loaded\nwith siRNA as a novel approach for efficient siRNA drug delivery to\ntreat ulcerative colitis","volume":"12","author":"Zhang","year":"2017","journal-title":"Nanomedicine"},{"issue":"16","key":"2026091714070333000_cit170","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202410124","article-title":"Dual-Carriers of Tartary Buckwheat-Derived\nExosome-Like Nanovesicles\nSynergistically Regulate Glucose Metabolism in the Intestine-Liver\nAxis","volume":"21","author":"Li","year":"2025","journal-title":"Small"},{"key":"2026091714070333000_cit171","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2026.115154","article-title":"Harnessing\nplant-derived extracellular vesicles for oral delivery: A dual role\nas natural therapeutics and engineered drug carriers","volume":"397","author":"Huang","year":"2026","journal-title":"J. Controlled Release"},{"issue":"1","key":"2026091714070333000_cit172","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s13346-024-01621-x","article-title":"Plant-derived exosome-like nanoparticles\nfor microRNA delivery in cancer treatment","volume":"15","author":"Yi","year":"2025","journal-title":"Drug\nDelivery Transl. Res."},{"issue":"1","key":"2026091714070333000_cit173","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-026-04321-5","article-title":"Preventive effects\nand mechanisms of yam exosome-like nanoparticles on acute liver injury","volume":"24","author":"Yao","year":"2026","journal-title":"J. Nanobiotechnol."},{"key":"2026091714070333000_cit174","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2026.102688","article-title":"Plant-derived\nextracellular vesicles\nas bioactive nanoplatforms: Biogenesis, therapeutic evidence, and\ntranslational challenges","volume":"47","author":"Yu","year":"2026","journal-title":"Biochem. Biophys.\nRep."},{"key":"2026091714070333000_cit175","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2026.111944","article-title":"Toxicology and biodistribution\nof\nplant-derived extracellular vesicles for drug delivery: Quality control,\nsafety mechanisms, and translational testing priorities","volume":"422","author":"Naseem","year":"2026","journal-title":"Toxicol. Lett."},{"key":"2026091714070333000_cit176","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2026.100530","article-title":"Cargo-driven extracellular\nvesicles\nas pharmaceutical nanocarriers: A pharmaceutics-oriented comparison\nof animal exosomes and plant-derived exosome-like nanoparticles","volume":"11","author":"Xu","year":"2026","journal-title":"Int. J. Pharm. X"},{"key":"2026091714070333000_cit177","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.biomaterials.2016.06.018","article-title":"Edible ginger-derived nanoparticles:\nA novel therapeutic approach for the prevention and treatment of inflammatory\nbowel disease and colitis-associated cancer","volume":"101","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"issue":"2","key":"2026091714070333000_cit178","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide\nfor dose\nconversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic\nClin. Pharm."},{"key":"2026091714070333000_cit179","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1223349","article-title":"Ginger: a representative material\nof herb-derived exosome-like\nnanoparticles","volume":"10","author":"Zhu","year":"2023","journal-title":"Front. Nutr."},{"issue":"12","key":"2026091714070333000_cit180","doi-asserted-by":"publisher","first-page":"5596","DOI":"10.7150\/thno.73650","article-title":"Turmeric-derived nanovesicles\nas novel nanobiologics for targeted\ntherapy of ulcerative colitis","volume":"12","author":"Gao","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"2026091714070333000_cit181","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01835-0","article-title":"Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING\npathway to remold tumor-associated macrophages for tumor regression","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026091714070333000_cit182","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010087","article-title":"Strawberry-Derived Exosome-Like Nanoparticles\nPrevent Oxidative Stress in Human Mesenchymal Stromal Cells","volume":"11","author":"Perut","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"2026091714070333000_cit183","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/cr.2011.158","article-title":"Exogenous\nplant MIR168a specifically targets mammalian LDLRAP1: evidence of\ncross-kingdom regulation by microRNA","volume":"22","author":"Zhang","year":"2012","journal-title":"Cell Res."},{"key":"2026091714070333000_cit184","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14060.1","article-title":"Alternative\nmiRNAs? Human sequences misidentified as\nplant miRNAs in plant studies and in human plasma","volume":"7","author":"Witwer","year":"2018","journal-title":"F1000Research"},{"issue":"4","key":"2026091714070333000_cit185","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1261\/rna.059725.116","article-title":"Survey\nof 800+ data sets from human tissue and body\nfluid reveals xenomiRs are likely artifacts","volume":"23","author":"Kang","year":"2017","journal-title":"RNA"},{"key":"2026091714070333000_cit186","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1827379","article-title":"Oral plant-derived\nexosome-like nanovesicles: a new therapeutic perspective for intestinal\ndiseases","volume":"17","author":"Zhang","year":"2026","journal-title":"Front. Pharmacol."},{"key":"2026091714070333000_cit187","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5186","article-title":"Identification of exosome-like nanoparticle-derived\nmicroRNAs from 11 edible fruits and vegetables","volume":"6","author":"Xiao","year":"2018","journal-title":"PeerJ"},{"key":"2026091714070333000_cit188","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.omtm.2021.03.006","article-title":"Acerola exosome-like\nnanovesicles\nto systemically deliver nucleic acid medicine via oral administration","volume":"21","author":"Umezu","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"1","key":"2026091714070333000_cit189","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03567-9","article-title":"Prunus mume derived\nextracellular vesicle-like particles alleviate experimental colitis\nvia disrupting NEK7-NLRP3 interaction and inflammasome activation","volume":"23","author":"Lv","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"2026091714070333000_cit190","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030647","article-title":"Glucose Uptake\nby Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise:\nAn Integrated Approach","volume":"14","author":"Hulett","year":"2022","journal-title":"Nutrients"},{"key":"2026091714070333000_cit191","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.821849","article-title":"Changes in Skeletal\nMuscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body\nGlucose Homeostasis","volume":"13","author":"Merz","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"3","key":"2026091714070333000_cit192","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s10741-021-10211-9","article-title":"Renal effects of SGLT2 inhibitors in cardiovascular\npatients with and without chronic kidney disease: focus on heart failure\nand renal outcomes","volume":"28","author":"Gronda","year":"2023","journal-title":"Heart Fail Rev."},{"issue":"5","key":"2026091714070333000_cit193","doi-asserted-by":"publisher","first-page":"556","DOI":"10.4239\/wjd.v12.i5.556","article-title":"Renal gluconeogenesis\nin insulin\nresistance: A culprit for hyperglycemia in diabetes","volume":"12","author":"Sharma","year":"2021","journal-title":"World J. Diabetes"},{"key":"2026091714070333000_cit194","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157573","article-title":"Anemarrhena asphodeloides-derived\nsmall extracellular vesicle ameliorate diabetes-induced muscle atrophy\nvia activating Pink1-mediated mitophagy","volume":"149","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"issue":"5","key":"2026091714070333000_cit195","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12051098","article-title":"Diabetes and Renal Complications:\nAn Overview on Pathophysiology,\nBiomarkers and Therapeutic Interventions","volume":"12","author":"Jha","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"2026091714070333000_cit196","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2026.2645772","article-title":"Dandelion\nexosome-like nanovesicles alleviate sepsis-induced acute kidney injury\nvia SLC7A11-regulated ferroptosis","volume":"48","author":"Zhang","year":"2026","journal-title":"Ren Fail"},{"key":"2026091714070333000_cit197","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-026-04503-1","article-title":"Exosomal nanovesicles derived from Atractylodes macrocephala\ndelivering\nexogenous miRNA-146a-5p for treatment of sepsis-induced acute kidney\ninjury","volume":"24","author":"Yan","year":"2026","journal-title":"J. Nanobiotechnol."},{"issue":"14","key":"2026091714070333000_cit198","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142232","article-title":"Emergence of Edible\nPlant-Derived\nNanovesicles as Functional Food Components and Nanocarriers for Therapeutics\nDelivery: Potentials in Human Health and Disease","volume":"11","author":"Kim","year":"2022","journal-title":"Cells"},{"issue":"7","key":"2026091714070333000_cit199","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073719","article-title":"Plant Extracellular\nVesicles and Nanovesicles: Focus\non Secondary Metabolites, Proteins and Lipids with Perspectives on\nTheir Potential and Sources","volume":"22","author":"Woith","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026091714070333000_cit200","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jconrel.2023.01.071","article-title":"Yam-derived exosome-like nanovesicles stimulate osteoblast\nformation and prevent osteoporosis in mice","volume":"355","author":"Hwang","year":"2023","journal-title":"J. Controlled Release"},{"key":"2026091714070333000_cit201","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102271","article-title":"Characterization\nof and isolation methods for plant leaf nanovesicles and small extracellular\nvesicles","volume":"29","author":"Liu","year":"2020","journal-title":"Nanomedicine"},{"issue":"1","key":"2026091714070333000_cit202","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuab044","article-title":"Communication is key:\nextracellular vesicles as mediators of infection and defence during\nhost-microbe interactions in animals and plants","volume":"46","author":"Stotz","year":"2022","journal-title":"FEMS Microbiol. Rev."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c05063","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/35\/27323\/67391608\/acs.jafc.6c05063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/35\/27323\/67391608\/acs.jafc.6c05063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:29:12Z","timestamp":1789669752000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/35\/27323\/5328135\/Plant-Derived-Nanovesicles-as-a-Cross-Kingdom"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":202,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,24]]},"published-print":{"date-parts":[[2026,9,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c05063","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]}}}