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In this study, we identified compound Q1, a pyrido[2,3-d]pyrimidine-2,4-dione derivative, which exhibits slightly superior insecticidal activity against hemipteran pests compared to triflumezopyrim, with an LC50 value of 2.83 mg\/L against Acyrthosiphon pisum, whereas triflumezopyrim shows an LC50 of 2.92 mg\/L. Multi-omics integrated analysis confirmed that \u03b16 serves as a key regulatory hub for maintaining normal energy metabolism and redox homeostasis in aphids. Q1 specifically targets the nAChR \u03b16 subunit, disrupting ionic balance, inducing ROS bursts, and inhibiting ATP synthesis, ultimately leading to insect death. Importantly, Q1 exhibited no obvious toxicity to non-target organisms including honeybees, fish, and earthworms at tested concentrations. These findings highlight Q1 as a promising and safer alternative for sustainable hemipteran pest management.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c05097","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:02:42Z","timestamp":1789225362000},"page":"29071-29087","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of A\nSafe and Effective Hemipteran Insecticide:\n\u03b16 nAChR-Targeting Non-Mesoionic Scaffold"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8404-3695","authenticated-orcid":true,"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, P. R. China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-5320","authenticated-orcid":true,"given":"Luoman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, P. R. China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Wu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Sanya, China, 572025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4847-3541","authenticated-orcid":true,"given":"Yanqun","family":"Peng","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, P. R. China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7259","authenticated-orcid":true,"given":"Zengxue","family":"Wu","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, P. R. 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Physiol."},{"key":"2026092310080710500_cit38","doi-asserted-by":"publisher","first-page":"12176","DOI":"10.1021\/acs.jafc.5c01017","article-title":"Multiple mutations in the \u03b21 subunit of the nicotinic\nacetylcholine receptor confer resistance to neonicotinoids","volume":"73","author":"Cheng","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026092310080710500_cit39","doi-asserted-by":"publisher","first-page":"105191","DOI":"10.1016\/j.pestbp.2022.105191","article-title":"CRISPR-mediated\nknockout of nicotinic acetylcholine receptor (nAChR) \u03b16 subunit\nconfers high levels of resistance to spinosyns in Spodoptera frugiperda","volume":"187","author":"Shi","year":"2022","journal-title":"Pestic. Biochem. 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